Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GHRHR
  • Mouse genes Ghrhr
  • Rat genes Ghrhr
  • Zfish genes ghrhra,ghrhrb,ghrhrl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ghrhr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019838	growth factor binding	GHRHR	IPI	UniProtKB:P01286	Human	PMID:7680413
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	GHRHR	IMP		Human	PMID:7680413
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	Ghrhr	IGI	MGI:MGI:95709	Mouse	PMID:8391647
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:10537133
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	Ghrhr	IDA		Rat	PMID:11814616|RGD:728748
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	Ghrhr	IDA		Rat	PMID:12161265|RGD:728477
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	ghrhra	IDA		Zfish	PMID:17283332
Molecular Function	GO:0017046	peptide hormone binding	GHRHR	IPI	UniProtKB:P01286	Human	PMID:7680413
Molecular Function	GO:0017046	peptide hormone binding	Ghrhr	IPI	UniProtKB:P16043	Mouse	MGI:MGI:3833824|PMID:11773624
Molecular Function	GO:0005515	protein binding	GHRHR	IPI	UniProtKB:P01286	Human	PMID:1333056
Molecular Function	GO:0005515	protein binding	GHRHR	IPI	UniProtKB:P18509	Human	PMID:7680413
Molecular Function	GO:0005515	protein binding	Ghrhr	IPI	PR:P16043	Mouse	PMID:10537133
Cellular Component	GO:0009986	cell surface	GHRHR	IDA		Human	PMID:1333056
Cellular Component	GO:0009986	cell surface	Ghrhr	IDA		Rat	PMID:10465288|RGD:1624951
Cellular Component	GO:0005737	cytoplasm	GHRHR	IDA		Human	PMID:10461027
Cellular Component	GO:0016020	membrane	GHRHR	IDA		Human	PMID:1333056
Cellular Component	GO:0016020	membrane	Ghrhr	IDA		Mouse	PMID:10537133
Cellular Component	GO:0005637	nuclear inner membrane	GHRHR	IDA		Human	PMID:10461027
Cellular Component	GO:0016363	nuclear matrix	GHRHR	IDA		Human	PMID:10461027
Cellular Component	GO:0005640	nuclear outer membrane	GHRHR	IDA		Human	PMID:10461027
Cellular Component	GO:0005886	plasma membrane	GHRHR	IDA		Human	PMID:10461027
Cellular Component	GO:0005886	plasma membrane	Ghrhr	IDA		Mouse	PMID:10537133
Cellular Component	GO:0005886	plasma membrane	Ghrhr	IDA		Rat	PMID:15499571|RGD:1358713
Cellular Component	GO:0042383	sarcolemma	Ghrhr	IDA		Rat	PMID:19293247|RGD:2325187
Cellular Component	GO:0030141	secretory granule	GHRHR	IDA		Human	PMID:10461027
Biological Process	GO:0007190	activation of adenylate cyclase activity	Ghrhr	IDA		Rat	PMID:9845677|RGD:1601338
Biological Process	GO:0021984	adenohypophysis development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1270792
Biological Process	GO:0021984	adenohypophysis development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1329576
Biological Process	GO:0021984	adenohypophysis development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1504465
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GHRHR	IDA		Human	PMID:1333056
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GHRHR	IDA		Human	PMID:7680413
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Ghrhr	IGI	MGI:MGI:95709	Mouse	PMID:8391647
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Ghrhr	IGI	MGI:MGI:95709	Mouse	PMID:1334535
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:3008329
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:10537133
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Ghrhr	IGI	MGI:MGI:95709	Mouse	PMID:8395283
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ghrhra	IDA		Zfish	PMID:18757498
Biological Process	GO:0019933	cAMP-mediated signaling	GHRHR	IMP		Human	PMID:7680413
Biological Process	GO:0019933	cAMP-mediated signaling	Ghrhr	IDA		Rat	PMID:10465288|RGD:1624951
Biological Process	GO:0048469	cell maturation	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:2980124
Biological Process	GO:0071333	cellular response to glucose stimulus	Ghrhr	IEP		Rat	PMID:18285528|RGD:10401258
Biological Process	GO:0032869	cellular response to insulin stimulus	Ghrhr	IDA		Mouse	PMID:16513828
Biological Process	GO:0008340	determination of adult lifespan	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:11371619
Biological Process	GO:0051649	establishment of localization in cell	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:3008329
Biological Process	GO:0030252	growth hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:3008329
Biological Process	GO:0042445	hormone metabolic process	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1270792
Biological Process	GO:0046879	hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:7679139
Biological Process	GO:0007595	lactation	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1270792
Biological Process	GO:0007595	lactation	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:2980124
Biological Process	GO:0030879	mammary gland development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:15059953
Biological Process	GO:0008284	positive regulation of cell population proliferation	GHRHR	IDA		Human	PMID:12867592
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ghrhr	IMP		Mouse	MGI:MGI:3833824|PMID:11773624
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	Ghrhr	IMP		Rat	PMID:20237285|RGD:10401262
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:6303755
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:978118
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:3008329
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Ghrhr	IMP		Rat	PMID:23825127|RGD:10401239
Biological Process	GO:0046887	positive regulation of hormone secretion	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:7679139
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GHRHR	IMP		Human	PMID:8528260
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1778592
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:7679139
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IGI	MGI:MGI:1201787	Mouse	PMID:15690087
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:10689811
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:1270792
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:15690087
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:7390396
Biological Process	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:7679139
Biological Process	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:10459853
Biological Process	GO:0051246	regulation of protein metabolic process	Ghrhr	IGI	MGI:MGI:96432	Mouse	PMID:7510770
Biological Process	GO:0043627	response to estrogen	GHRHR	IDA		Human	PMID:9482665
Biological Process	GO:0051384	response to glucocorticoid	GHRHR	IDA		Human	PMID:9482665
Biological Process	GO:0032868	response to insulin	GHRHR	IMP		Human	PMID:17356054
Biological Process	GO:0007165	signal transduction	Ghrhr	IDA		Rat	PMID:12446584|RGD:628502
Biological Process	GO:0007165	signal transduction	ghrhra	IDA		Zfish	PMID:17283332
Biological Process	GO:0060133	somatotropin secreting cell development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:6194978
Biological Process	GO:0060133	somatotropin secreting cell development	Ghrhr	IMP	MGI:MGI:1856425	Mouse	PMID:6116352

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern