Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ghsr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GHSR
- Mouse genes Ghsr
- Rat genes Ghsr
- Zfish genes ghsra,ghsrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ghsr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	GHSR	IDA		Human	PMID:8688086
Molecular Function	GO:0001616	growth hormone secretagogue receptor activity	GHSR	IDA		Human	PMID:8688086
Molecular Function	GO:0001616	growth hormone secretagogue receptor activity	Ghsr	IMP		Rat	PMID:17109695\|RGD:1624382
Molecular Function	GO:0001616	growth hormone secretagogue receptor activity	Ghsr	IDA		Rat	PMID:9092793\|RGD:728631
Molecular Function	GO:0016520	growth hormone-releasing hormone receptor activity	GHSR	IDA		Human	PMID:8688086
Molecular Function	GO:0042562	hormone binding	Ghsr	IPI	UniProtKB:Q9QYH7	Rat	PMID:10604470\|RGD:625505
Molecular Function	GO:0017046	peptide hormone binding	Ghsr	IMP		Rat	PMID:17109695\|RGD:1624382
Molecular Function	GO:0005515	protein binding	Ghsr	IPI	UniProtKB:Q9QYH7	Rat	PMID:10604470\|RGD:625505
Molecular Function	GO:0005515	protein binding	Ghsr	IPI	UniProtKB:Q8JFY4	Rat	PMID:12630926\|RGD:8554737
Cellular Component	GO:0009986	cell surface	GHSR	IDA		Human	PMID:8688086
Cellular Component	GO:0005737	cytoplasm	ghsra	IDA		Zfish	PMID:24928276
Cellular Component	GO:0005737	cytoplasm	ghsrb	IDA		Zfish	PMID:24928276
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	EXP		Rat	PMID:22516464\|RGD:13702295
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	IDA		Rat	PMID:22516464\|RGD:13702295
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	EXP		Rat	PMID:24367106\|RGD:13702206
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	IDA		Rat	PMID:24367106\|RGD:13702206
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	IMP		Rat	PMID:24367106\|RGD:13702206
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	EXP		Rat	PMID:26153524\|RGD:13702301
Cellular Component	GO:0098978	glutamatergic synapse	Ghsr	IDA		Rat	PMID:26153524\|RGD:13702301
Cellular Component	GO:0045121	membrane raft	GHSR	IDA		Human	PMID:15232612
Cellular Component	GO:0043005	neuron projection	GHSR	IDA		Human	PMID:12890514
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ghsra	IDA		Zfish	PMID:24928276
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ghsrb	IDA		Zfish	PMID:24928276
Cellular Component	GO:0005886	plasma membrane	Ghsr	IDA		Rat	PMID:23160599\|RGD:12910117
Cellular Component	GO:0005886	plasma membrane	ghsra	IDA		Zfish	PMID:24928276
Cellular Component	GO:0005886	plasma membrane	ghsrb	IDA		Zfish	PMID:24928276
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ghsr	EXP		Rat	PMID:26153524\|RGD:13702301
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ghsr	IDA		Rat	PMID:26153524\|RGD:13702301
Cellular Component	GO:0097060	synaptic membrane	Ghsr	IDA		Rat	PMID:24367106\|RGD:13702206
Cellular Component	GO:0097060	synaptic membrane	Ghsr	IMP		Rat	PMID:24367106\|RGD:13702206
Biological Process	GO:0008154	actin polymerization or depolymerization	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:0008343	adult feeding behavior	Ghsr	IMP		Mouse	MGI:MGI:3612647\|PMID:16322794
Biological Process	GO:0032869	cellular response to insulin stimulus	Ghsr	IDA		Mouse	PMID:16513828
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Ghsr	IEP		Rat	PMID:15680488\|RGD:12907504
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ghsr	IEP		Rat	PMID:15155262\|RGD:12905047
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	Ghsr	IEP		Rat	PMID:11207942\|RGD:12910111
Biological Process	GO:0046697	decidualization	GHSR	IDA		Human	PMID:17494105
Biological Process	GO:0007565	female pregnancy	Ghsr	IEP		Rat	PMID:20814072\|RGD:12905049
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GHSR	IDA		Human	PMID:8688086
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ghsr	IDA		Rat	PMID:9092793\|RGD:728631
Biological Process	GO:0036321	ghrelin secretion	Ghsr	IMP		Rat	PMID:21778696\|RGD:12905045
Biological Process	GO:0030252	growth hormone secretion	Ghsr	IGI	MGI:MGI:1930008	Mouse	PMID:15070777
Biological Process	GO:0009755	hormone-mediated signaling pathway	GHSR	IDA		Human	PMID:8688086
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Ghsr	IMP	MGI:MGI:3040440	Mouse	PMID:15070777
Biological Process	GO:0007611	learning or memory	Ghsr	IDA		Rat	PMID:19652956\|RGD:12910107
Biological Process	GO:0032099	negative regulation of appetite	Ghsr	IMP		Rat	PMID:21778696\|RGD:12905045
Biological Process	GO:0050728	negative regulation of inflammatory response	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:0046676	negative regulation of insulin secretion	Ghsr	IDA		Rat	PMID:17130496\|RGD:8553721
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:0032715	negative regulation of interleukin-6 production	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:0090327	negative regulation of locomotion involved in locomotory behavior	Ghsr	IMP		Rat	PMID:19931319\|RGD:12910109
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	Ghsr	IMP		Rat	PMID:25337654\|RGD:12907499
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	Ghsr	IMP		Rat	PMID:17911350\|RGD:12907501
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Ghsr	IMP		Rat	PMID:17911350\|RGD:12907501
Biological Process	GO:0032100	positive regulation of appetite	Ghsr	IMP		Mouse	MGI:MGI:3612647\|PMID:16322794
Biological Process	GO:1904000	positive regulation of eating behavior	Ghsr	IMP		Rat	PMID:26512025\|RGD:12904888
Biological Process	GO:0045923	positive regulation of fatty acid metabolic process	Ghsr	IMP		Rat	PMID:12045256\|RGD:625699
Biological Process	GO:0045927	positive regulation of growth	Ghsr	IMP		Rat	PMID:12045256\|RGD:625699
Biological Process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	Ghsr	IMP	MGI:MGI:3040440	Mouse	PMID:15070777
Biological Process	GO:0040018	positive regulation of multicellular organism growth	GHSR	IMP		Human	PMID:16511605
Biological Process	GO:0120058	positive regulation of small intestinal transit	Ghsr	IMP		Rat	PMID:15890336\|RGD:12907565
Biological Process	GO:0120058	positive regulation of small intestinal transit	Ghsr	IMP		Rat	PMID:21874246\|RGD:12910732
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	Ghsr	IMP		Rat	PMID:15890336\|RGD:12907565
Biological Process	GO:1904349	positive regulation of small intestine smooth muscle contraction	Ghsr	IMP		Rat	PMID:21874246\|RGD:12910732
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Ghsr	IMP		Rat	PMID:21642627\|RGD:12904963
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	Ghsr	IMP		Rat	PMID:21642627\|RGD:12904963
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ghsr	EXP		Rat	PMID:26153524\|RGD:13702301
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	Ghsr	IDA		Rat	PMID:26153524\|RGD:13702301
Biological Process	GO:0060259	regulation of feeding behavior	Ghsr	IMP		Rat	PMID:12045256\|RGD:625699
Biological Process	GO:1905333	regulation of gastric motility	Ghsr	IMP		Rat	PMID:23525979\|RGD:12907567
Biological Process	GO:0060123	regulation of growth hormone secretion	Ghsr	IMP		Rat	PMID:12045256\|RGD:625699
Biological Process	GO:0043134	regulation of hindgut contraction	Ghsr	IMP		Rat	PMID:16873401\|RGD:1625276
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Ghsr	EXP		Rat	PMID:24367106\|RGD:13702206
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Ghsr	IDA		Rat	PMID:24367106\|RGD:13702206
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Ghsr	IEP		Rat	PMID:24367106\|RGD:13702206
Biological Process	GO:0099175	regulation of postsynapse organization	Ghsr	EXP		Rat	PMID:22516464\|RGD:13702295
Biological Process	GO:0099175	regulation of postsynapse organization	Ghsr	IDA		Rat	PMID:22516464\|RGD:13702295
Biological Process	GO:0051963	regulation of synapse assembly	Ghsr	IMP	MGI:MGI:3040440	Mouse	PMID:17060947
Biological Process	GO:0051969	regulation of transmission of nerve impulse	Ghsr	IMP		Rat	PMID:23525979\|RGD:12907567
Biological Process	GO:0071548	response to dexamethasone	Ghsr	IEP		Rat	PMID:10844575\|RGD:12910112
Biological Process	GO:0032355	response to estradiol	Ghsr	IEP		Rat	PMID:24473434\|RGD:12905050
Biological Process	GO:0032354	response to follicle-stimulating hormone	Ghsr	IEP		Rat	PMID:12606422\|RGD:12910108
Biological Process	GO:0032094	response to food	Ghsr	IDA		Mouse	PMID:16513828
Biological Process	GO:0060416	response to growth hormone	Ghsr	IEP		Rat	PMID:9822798\|RGD:12904721
Biological Process	GO:0009725	response to hormone	GHSR	IDA		Human	PMID:15232612
Biological Process	GO:1902065	response to L-glutamate	Ghsr	IEP		Rat	PMID:10718930\|RGD:12910114
Biological Process	GO:0007283	spermatogenesis	Ghsr	IEP		Rat	PMID:12606422\|RGD:12910108

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.