Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GJA3
  • Mouse genes Gja3
  • Rat genes Gja3
  • Zfish genes gja3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gja3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005243	gap junction channel activity	Gja3	IDA		Rat	PMID:1659572|RGD:728416
Molecular Function	GO:0055077	gap junction hemi-channel activity	GJA3	IDA		Human	PMID:30044662
Molecular Function	GO:0055077	gap junction hemi-channel activity	Gja3	IDA		Rat	PMID:17715132|RGD:15090844
Molecular Function	GO:0055077	gap junction hemi-channel activity	gja3	IDA		Zfish	PMID:15213236
Molecular Function	GO:0042802	identical protein binding	Gja3	IDA		Rat	PMID:9151687|RGD:1599827
Molecular Function	GO:0005515	protein binding	Gja3	IPI	RGD:2280	Rat	PMID:15467523|RGD:1599825
Cellular Component	GO:0005922	connexin complex	GJA3	IDA		Human	PMID:30044662
Cellular Component	GO:0005921	gap junction	Gja3	IDA		Mouse	PMID:11786642
Cellular Component	GO:0005921	gap junction	Gja3	IDA		Rat	PMID:1659572|RGD:728416
Cellular Component	GO:0045121	membrane raft	Gja3	IDA		Rat	PMID:15467523|RGD:1599825
Cellular Component	GO:0005886	plasma membrane	GJA3	IDA		Human	PMID:30044662
Cellular Component	GO:0005886	plasma membrane	Gja3	IDA		Mouse	PMID:9620080
Biological Process	GO:0003161	cardiac conduction system development	gja3	IMP	ZFIN:ZDB-GENO-100831-18	Zfish	PMID:20675583
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	gja3	IMP	ZFIN:ZDB-GENO-100901-3	Zfish	PMID:20675583
Biological Process	GO:0010644	cell communication by electrical coupling	gja3	IMP	ZFIN:ZDB-GENO-100831-18	Zfish	PMID:20675583
Biological Process	GO:1990349	gap junction-mediated intercellular transport	GJA3	IDA		Human	PMID:30044662
Biological Process	GO:0048050	post-embryonic eye morphogenesis	gja3	IMP		Zfish	PMID:15213236
Biological Process	GO:0008016	regulation of heart contraction	gja3	IMP		Zfish	PMID:15213236
Biological Process	GO:0042542	response to hydrogen peroxide	Gja3	IDA		Rat	PMID:15467523|RGD:1599825
Biological Process	GO:0009268	response to pH	Gja3	IDA		Rat	PMID:11889584|RGD:1599826

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern