Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gja5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GJA5
- Mouse genes Gja5
- Rat genes Gja5
- Zfish genes gja5a,gja5b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gja5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071253	connexin binding	Gja5	IPI	RGD:2690	Rat	PMID:11557558\|RGD:7207849
Molecular Function	GO:0097718	disordered domain specific binding	Gja5	IPI	UniProtKB:P08050	Rat	PMID:19808665\|RGD:12793009
Molecular Function	GO:0005243	gap junction channel activity	Gja5	IDA		Rat	PMID:1328644\|RGD:728713
Molecular Function	GO:0005243	gap junction channel activity	gja5a	IDA		Zfish	PMID:14704230
Molecular Function	GO:0086076	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling	GJA5	IMP		Human	PMID:16790700
Molecular Function	GO:0086076	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling	GJA5	IMP		Human	PMID:20606116
Molecular Function	GO:0086076	gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling	GJA5	IMP		Human	PMID:23348765
Molecular Function	GO:0086077	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	GJA5	IDA		Human	PMID:22247482
Molecular Function	GO:0086078	gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling	GJA5	IMP		Human	PMID:22247482
Molecular Function	GO:0086078	gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling	Gja5	IMP		Mouse	MGI:MGI:6101691\|PMID:26786475
Molecular Function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	GJA5	IMP		Human	PMID:16790700
Molecular Function	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling	GJA5	IDA		Human	PMID:23348765
Molecular Function	GO:0055077	gap junction hemi-channel activity	GJA5	IDA		Human	PMID:23348765
Molecular Function	GO:0055077	gap junction hemi-channel activity	gja5b	IDA		Zfish	PMID:16845369
Molecular Function	GO:0055077	gap junction hemi-channel activity	gja5b	IMP	ZFIN:ZDB-GENO-980202-1294	Zfish	PMID:16845369
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:O15243	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:O60831	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:O95214	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P24593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P29033	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P54852	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P55061	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P62952	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q5T1Q4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q6P499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q6UX40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q6ZP29-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q6ZUX7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q86Y07	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q8IVJ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q8WVX3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q96EC8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q96JW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q9NSU2-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q9UHJ9-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q9UKG4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA5	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	gja5b	IPI	ZFIN:ZDB-GENE-031001-2	Zfish	PMID:25915619
Cellular Component	GO:0042995	cell projection	Gja5	IDA		Rat	PMID:16037574\|RGD:7207813
Cellular Component	GO:0005922	connexin complex	GJA5	IDA		Human	PMID:22247482
Cellular Component	GO:0005922	connexin complex	Gja5	IDA		Rat	PMID:1328644\|RGD:728713
Cellular Component	GO:0005922	connexin complex	Gja5	IDA		Rat	PMID:9851942\|RGD:1598435
Cellular Component	GO:0005922	connexin complex	Gja5	IMP		Rat	PMID:19808665\|RGD:12793009
Cellular Component	GO:0005921	gap junction	GJA5	IDA		Human	PMID:23348765
Cellular Component	GO:0005921	gap junction	Gja5	IDA		Mouse	PMID:9501070
Cellular Component	GO:0014704	intercalated disc	GJA5	IDA		Human	PMID:16790700
Cellular Component	GO:0005886	plasma membrane	GJA5	IDA		Human	PMID:22247482
Biological Process	GO:0030534	adult behavior	gja5b	IMP	ZFIN:ZDB-GENO-050426-1	Zfish	PMID:28007536
Biological Process	GO:0001525	angiogenesis	GJA5	IEP		Human	PMID:11866539
Biological Process	GO:0048844	artery morphogenesis	Gja5	IMP		Mouse	MGI:MGI:4462093\|PMID:20530546
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	GJA5	IMP		Human	PMID:16790700
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	GJA5	IMP		Human	PMID:20606116
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	GJA5	IMP		Human	PMID:23348765
Biological Process	GO:0086044	atrial cardiac muscle cell to AV node cell communication by electrical coupling	Gja5	IMP		Mouse	MGI:MGI:3696497\|PMID:10515563
Biological Process	GO:0003283	atrial septum development	GJA5	IMP		Human	PMID:22199024
Biological Process	GO:0060413	atrial septum morphogenesis	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0003294	atrial ventricular junction remodeling	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0086067	AV node cell to bundle of His cell communication	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10515563
Biological Process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0086053	AV node cell to bundle of His cell communication by electrical coupling	Gja5	IMP		Mouse	MGI:MGI:3696497\|PMID:10515563
Biological Process	GO:0001568	blood vessel development	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:12435353
Biological Process	GO:0097746	blood vessel diameter maintenance	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10747000
Biological Process	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0086054	bundle of His cell to Purkinje myocyte communication by electrical coupling	Gja5	IMP		Mouse	MGI:MGI:6101691\|PMID:26786475
Biological Process	GO:0061337	cardiac conduction	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:9501069
Biological Process	GO:0061337	cardiac conduction	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:18599871
Biological Process	GO:0061337	cardiac conduction	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:9501070
Biological Process	GO:0061337	cardiac conduction	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10515563
Biological Process	GO:0061337	cardiac conduction	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0003161	cardiac conduction system development	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:18599871
Biological Process	GO:0003161	cardiac conduction system development	Gja5	IMP		Mouse	PMID:22203979
Biological Process	GO:0010643	cell communication by chemical coupling	Gja5	IDA		Rat	PMID:1328644\|RGD:728713
Biological Process	GO:0010644	cell communication by electrical coupling	Gja5	IDA		Rat	PMID:7554128\|RGD:7207842
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	GJA5	IDA		Human	PMID:16790700
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	GJA5	IDA		Human	PMID:23348765
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:11046183
Biological Process	GO:0086065	cell communication involved in cardiac conduction	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10747000
Biological Process	GO:0035050	embryonic heart tube development	Gja5	IMP		Mouse	PMID:22203979
Biological Process	GO:0035050	embryonic heart tube development	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:14732399
Biological Process	GO:0030326	embryonic limb morphogenesis	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:15923624
Biological Process	GO:0003158	endothelium development	Gja5	IEP		Rat	PMID:10990491\|RGD:7207853
Biological Process	GO:0035922	foramen ovale closure	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0016264	gap junction assembly	GJA5	IMP		Human	PMID:16790700
Biological Process	GO:0016264	gap junction assembly	GJA5	IDA		Human	PMID:22247482
Biological Process	GO:0016264	gap junction assembly	GJA5	IMP		Human	PMID:23348765
Biological Process	GO:0007507	heart development	Gja5	IEP		Rat	PMID:8944820\|RGD:7207856
Biological Process	GO:0030318	melanocyte differentiation	gja5b	IMP	ZFIN:ZDB-GENO-141229-1	Zfish	PMID:24173565
Biological Process	GO:0097324	melanocyte migration	gja5b	IMP	ZFIN:ZDB-GENO-141229-2	Zfish	PMID:24173565
Biological Process	GO:0097324	melanocyte migration	gja5b	IMP	ZFIN:ZDB-GENO-141229-1	Zfish	PMID:24173565
Biological Process	GO:0003174	mitral valve development	GJA5	IMP		Human	PMID:22199024
Biological Process	GO:0045776	negative regulation of blood pressure	Gja5	IMP		Rat	PMID:18046320\|RGD:7207467
Biological Process	GO:0003105	negative regulation of glomerular filtration	Gja5	IMP		Rat	PMID:17928514\|RGD:7207472
Biological Process	GO:0003151	outflow tract morphogenesis	GJA5	IMP		Human	PMID:22199024
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-140515-4	Zfish	PMID:22313791
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-150312-14	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-150312-22	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-150312-15	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-140515-4	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-160428-1	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-180504-2	Zfish	PMID:28835471
Biological Process	GO:0043473	pigmentation	gja5b	IGI	ZFIN:ZDB-GENO-150312-17	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-100726-1	Zfish	PMID:22313791
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-140515-5	Zfish	PMID:22313791
Biological Process	GO:0043473	pigmentation	gja5b	IGI	ZFIN:ZDB-GENO-151209-15	Zfish	PMID:25915619
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-140521-6	Zfish	PMID:22313791
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-100726-1	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja5b	IGI	ZFIN:ZDB-GENO-150312-18	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IGI	ZFIN:ZDB-GENO-150316-6	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-150227-3	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-160427-9	Zfish	PMID:26598520
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-150312-20	Zfish	PMID:25535837
Biological Process	GO:0043473	pigmentation	gja5b	IMP	ZFIN:ZDB-GENO-140521-7	Zfish	PMID:22313791
Biological Process	GO:0010652	positive regulation of cell communication by chemical coupling	Gja5	IMP		Rat	PMID:15678088\|RGD:7207816
Biological Process	GO:0045907	positive regulation of vasoconstriction	Gja5	IMP		Rat	PMID:21414209\|RGD:7207411
Biological Process	GO:0006813	potassium ion transport	Gja5	IDA		Rat	PMID:7554128\|RGD:7207842
Biological Process	GO:0003193	pulmonary valve formation	GJA5	IMP		Human	PMID:22199024
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	GJA5	IMP		Human	PMID:23348765
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	GJA5	IMP		Human	PMID:23348765
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10515563
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:9501070
Biological Process	GO:0098904	regulation of AV node cell action potential	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0098904	regulation of AV node cell action potential	Gja5	IMP		Mouse	MGI:MGI:3696497\|PMID:10515563
Biological Process	GO:0098905	regulation of bundle of His cell action potential	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0098905	regulation of bundle of His cell action potential	Gja5	IMP		Mouse	MGI:MGI:3696497\|PMID:10515563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	GJA5	IMP		Human	PMID:16790700
Biological Process	GO:0055117	regulation of cardiac muscle contraction	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:0055117	regulation of cardiac muscle contraction	GJA5	IMP		Human	PMID:23348765
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	Gja5	IDA		Rat	PMID:11557558\|RGD:7207849
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:11046183
Biological Process	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:9501070
Biological Process	GO:0098906	regulation of Purkinje myocyte action potential	GJA5	IMP		Human	PMID:22247482
Biological Process	GO:1900133	regulation of renin secretion into blood stream	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:17255527
Biological Process	GO:0003073	regulation of systemic arterial blood pressure	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10747000
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	Gja5	IMP		Mouse	MGI:MGI:6101691\|PMID:26786475
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	Gja5	IGI	MGI:MGI:95713	Mouse	PMID:10969038
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10515563
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:9501070
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Gja5	IMP		Mouse	MGI:MGI:6101691\|PMID:26786475
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Gja5	IGI	MGI:MGI:95713	Mouse	PMID:10969038
Biological Process	GO:0003071	renal system process involved in regulation of systemic arterial blood pressure	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:17255527
Biological Process	GO:0086015	SA node cell action potential	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:11046183
Biological Process	GO:0003284	septum primum development	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038
Biological Process	GO:0001501	skeletal system development	Gja5	IMP	MGI:MGI:2445466	Mouse	PMID:15923624
Biological Process	GO:0055085	transmembrane transport	gja5a	IDA		Zfish	PMID:14704230\|ZFIN:ZDB-PUB-040109-15
Biological Process	GO:0042311	vasodilation	Gja5	IMP		Rat	PMID:16037574\|RGD:7207813
Biological Process	GO:1990029	vasomotion	Gja5	IMP		Rat	PMID:16815985\|RGD:7207804
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:9501070
Biological Process	GO:0003281	ventricular septum development	GJA5	IMP		Human	PMID:22199024
Biological Process	GO:0060412	ventricular septum morphogenesis	Gja5	IMP	MGI:MGI:2445238	Mouse	PMID:10969038

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/09/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.