Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GJA1,GJA6P
  • Mouse genes Gja6
  • Rat genes Gja6
  • Zfish genes gja1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gja6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	GJA1	IPI	UniProtKB:P35222	Human	PMID:30992345
Molecular Function	GO:0005243	gap junction channel activity	GJA1	IDA		Human	PMID:16790700
Molecular Function	GO:0005243	gap junction channel activity	GJA1	IDA		Human	PMID:1696265
Molecular Function	GO:0005243	gap junction channel activity	GJA1	IDA		Human	PMID:23348765
Molecular Function	GO:0005243	gap junction channel activity	gja1a	IGI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:19808035
Molecular Function	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	GJA1	IDA		Human	PMID:1696265
Molecular Function	GO:0055077	gap junction hemi-channel activity	GJA1	IMP		Human	PMID:29366904
Molecular Function	GO:0015075	monoatomic ion transmembrane transporter activity	GJA1	IDA		Human	PMID:1696265
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q8VCZ6	Human	PMID:15709751
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q07157	Human	PMID:16944923
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q99683	Human	PMID:17761141
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q02487-1	Human	PMID:21220045
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:O43889-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:P19022	Human	PMID:29366904
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q07157	Human	PMID:29366904
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q07157	Human	PMID:30992345
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:O43889-2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q5BJH2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q5VZY2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q8N661	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q9NZG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q8TAB5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q9NP61	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GJA1	IPI	UniProtKB:Q07157	Human	PMID:9707407
Molecular Function	GO:0015631	tubulin binding	GJA1	IDA		Human	PMID:22558917
Cellular Component	GO:0030054	cell junction	GJA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030054	cell junction	GJA1	IDA		Human	PMID:29366904
Cellular Component	GO:0044291	cell-cell contact zone	GJA1	IDA		Human	PMID:11090614
Cellular Component	GO:0005737	cytoplasm	GJA1	IDA		Human	PMID:30599359
Cellular Component	GO:0005925	focal adhesion	GJA1	HDA		Human	PMID:21423176
Cellular Component	GO:0005921	gap junction	GJA1	IDA		Human	PMID:1696265
Cellular Component	GO:0005921	gap junction	GJA1	IDA		Human	PMID:23348765
Cellular Component	GO:0005921	gap junction	GJA1	IDA		Human	PMID:30599359
Cellular Component	GO:0005921	gap junction	gja1a	IGI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:19808035
Cellular Component	GO:0014704	intercalated disc	GJA1	IDA		Human	PMID:22889254
Cellular Component	GO:0014704	intercalated disc	GJA1	IDA		Human	PMID:23381804
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GJA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	GJA1	IDA		Human	PMID:15919068
Cellular Component	GO:0005739	mitochondrion	GJA1	IDA		Human	PMID:29163229
Cellular Component	GO:0005654	nucleoplasm	GJA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GJA1	IDA		Human	PMID:11090614
Cellular Component	GO:0005886	plasma membrane	GJA1	IDA		Human	PMID:30599359
Cellular Component	GO:0005886	plasma membrane	gja1a	IGI	ZFIN:ZDB-GENE-991105-4	Zfish	PMID:19808035
Cellular Component	GO:0070160	tight junction	GJA1	IDA		Human	PMID:30992345
Biological Process	GO:0010644	cell communication by electrical coupling	GJA1	IDA		Human	PMID:16790700
Biological Process	GO:0010644	cell communication by electrical coupling	GJA1	IDA		Human	PMID:1696265
Biological Process	GO:0010644	cell communication by electrical coupling	GJA1	IDA		Human	PMID:23348765
Biological Process	GO:0007267	cell-cell signaling	GJA1	IDA		Human	PMID:1696265
Biological Process	GO:0000132	establishment of mitotic spindle orientation	GJA1	IMP		Human	PMID:30992345
Biological Process	GO:0034220	monoatomic ion transmembrane transport	GJA1	IDA		Human	PMID:1696265
Biological Process	GO:0032277	negative regulation of gonadotropin secretion	GJA1	IMP		Human	PMID:30599359
Biological Process	GO:1901164	negative regulation of trophoblast cell migration	GJA1	IMP		Human	PMID:30599359
Biological Process	GO:0010628	positive regulation of gene expression	GJA1	IMP		Human	PMID:28342807
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GJA1	HMP		Human	PMID:12761501
Biological Process	GO:1905772	positive regulation of mesodermal cell differentiation	GJA1	IMP		Human	PMID:30599359
Biological Process	GO:1905332	positive regulation of morphogenesis of an epithelium	GJA1	IMP		Human	PMID:30992345
Biological Process	GO:2000648	positive regulation of stem cell proliferation	GJA1	IMP		Human	PMID:30599359
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	GJA1	IMP		Human	PMID:28342807
Biological Process	GO:0008104	protein localization	GJA1	IMP	UniProtKB:Q07157	Human	PMID:30992345
Biological Process	GO:0007165	signal transduction	GJA1	IDA		Human	PMID:1696265

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern