Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GJB2
  • Mouse genes Gjb2
  • Rat genes Gjb2
  • Zfish genes gjb8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gjb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	GJB2	IDA		Human	PMID:26753910
Molecular Function	GO:0005243	gap junction channel activity	GJB2	IDA		Human	PMID:12767933
Molecular Function	GO:0005243	gap junction channel activity	GJB2	IDA		Human	PMID:21094651
Molecular Function	GO:0005243	gap junction channel activity	Gjb2	IDA		Mouse	MGI:MGI:3603482|PMID:15692151
Molecular Function	GO:0005243	gap junction channel activity	Gjb2	IMP		Rat	PMID:23232329|RGD:7349364
Molecular Function	GO:0005243	gap junction channel activity	gjb8	IDA		Zfish	PMID:20737512
Molecular Function	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	GJB2	IDA		Human	PMID:12767933
Molecular Function	GO:0042802	identical protein binding	GJB2	IPI	UniProtKB:P29033	Human	PMID:17551008
Molecular Function	GO:0042802	identical protein binding	GJB2	IPI	UniProtKB:P29033	Human	PMID:19340074
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:O00623	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:O95279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P08034	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P26715	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P34981	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P35414	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P36382	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:P54219-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q0VAB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q3SXP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q6ZSS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q86WK6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q8N6K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q8WWF3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q96A25	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q96DS6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9BX73	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9HCJ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9NPL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9NR31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB2	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gjb2	IPI	UniProtKB:Q02738	Mouse	MGI:MGI:3603482|PMID:15692151
Molecular Function	GO:0005515	protein binding	Gjb2	IPI	PR:P70689	Mouse	PMID:14595769
Molecular Function	GO:0005515	protein binding	Gjb2	IPI	UniProtKB:Q8CBC4-3	Rat	PMID:19864490|RGD:8553631
Cellular Component	GO:0097449	astrocyte projection	Gjb2	IDA		Rat	PMID:11169992|RGD:11568657
Cellular Component	GO:0044297	cell body	Gjb2	IDA		Rat	PMID:11169992|RGD:11568657
Cellular Component	GO:0030054	cell junction	Gjb2	IDA		Rat	PMID:8770903|RGD:7349390
Cellular Component	GO:0005922	connexin complex	GJB2	IDA		Human	PMID:21094651
Cellular Component	GO:0005922	connexin complex	Gjb2	IDA		Mouse	MGI:MGI:3603482|PMID:15692151
Cellular Component	GO:0005737	cytoplasm	Gjb2	IDA		Rat	PMID:8601409|RGD:7349394
Cellular Component	GO:0005829	cytosol	Gjb2	IDA		Rat	PMID:11738649|RGD:11568663
Cellular Component	GO:0005921	gap junction	GJB2	IDA		Human	PMID:12767933
Cellular Component	GO:0005921	gap junction	Gjb2	IDA		Mouse	PMID:14595769
Cellular Component	GO:0005921	gap junction	Gjb2	IDA		Mouse	PMID:20089884
Cellular Component	GO:0005921	gap junction	Gjb2	IDA		Mouse	PMID:24590285
Cellular Component	GO:0005921	gap junction	Gjb2	IDA		Rat	PMID:12064610|RGD:632752
Cellular Component	GO:0005921	gap junction	Gjb2	IDA		Rat	PMID:12123633|RGD:12738139
Cellular Component	GO:0016328	lateral plasma membrane	Gjb2	IDA		Rat	PMID:12388089|RGD:628541
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Gjb2	IDA		Rat	PMID:11738649|RGD:11568663
Cellular Component	GO:0005886	plasma membrane	GJB2	IDA		Human	PMID:12767933
Cellular Component	GO:0005886	plasma membrane	GJB2	IDA		Human	PMID:21094651
Cellular Component	GO:0005886	plasma membrane	Gjb2	IDA		Mouse	MGI:MGI:3603482|PMID:15692151
Cellular Component	GO:0005886	plasma membrane	Gjb2	IDA		Rat	PMID:8770903|RGD:7349390
Biological Process	GO:0007568	aging	Gjb2	IEP		Rat	PMID:25159847|RGD:11568656
Biological Process	GO:0007267	cell-cell signaling	Gjb2	IDA		Mouse	MGI:MGI:3603482|PMID:15692151
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Gjb2	IEP		Rat	PMID:7593318|RGD:11568664
Biological Process	GO:0071377	cellular response to glucagon stimulus	Gjb2	IEP		Rat	PMID:7593318|RGD:11568664
Biological Process	GO:0034599	cellular response to oxidative stress	Gjb2	IEP		Rat	PMID:8631141|RGD:7349396
Biological Process	GO:0046697	decidualization	Gjb2	IEP		Rat	PMID:1655436|RGD:7349399
Biological Process	GO:0046697	decidualization	Gjb2	IEP		Rat	PMID:8924512|RGD:11568668
Biological Process	GO:1905867	epididymis development	Gjb2	IEP		Rat	PMID:12388089|RGD:628541
Biological Process	GO:0007565	female pregnancy	Gjb2	IEP		Rat	PMID:8612484|RGD:11568660
Biological Process	GO:0007565	female pregnancy	Gjb2	IEP		Rat	PMID:9389525|RGD:7349389
Biological Process	GO:0016264	gap junction assembly	GJB2	IDA		Human	PMID:12767933
Biological Process	GO:0016264	gap junction assembly	Gjb2	IMP		Mouse	PMID:24590285
Biological Process	GO:1990349	gap junction-mediated intercellular transport	GJB2	IDA		Human	PMID:12767933
Biological Process	GO:1990349	gap junction-mediated intercellular transport	GJB2	IDA		Human	PMID:21094651
Biological Process	GO:1990349	gap junction-mediated intercellular transport	Gjb2	IDA		Mouse	MGI:MGI:3603482|PMID:15692151
Biological Process	GO:0048839	inner ear development	Gjb2	IEP		Rat	PMID:10570462|RGD:1599834
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-GENO-230301-6	Zfish	PMID:32455934
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-GENO-230301-5	Zfish	PMID:32455934
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-MRPHLNO-140708-4	Zfish	PMID:24811980
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-MRPHLNO-140708-5	Zfish	PMID:24811980
Biological Process	GO:0046677	response to antibiotic	Gjb2	IEP		Rat	PMID:22896926|RGD:11568658
Biological Process	GO:0032355	response to estradiol	Gjb2	IEP		Rat	PMID:10342836|RGD:7349386
Biological Process	GO:0044752	response to human chorionic gonadotropin	Gjb2	IEP		Rat	PMID:9537254|RGD:7349388
Biological Process	GO:0002931	response to ischemia	Gjb2	IEP		Rat	PMID:24728265|RGD:11568671
Biological Process	GO:0032496	response to lipopolysaccharide	Gjb2	IEP		Rat	PMID:10909894|RGD:11568670
Biological Process	GO:0032570	response to progesterone	Gjb2	IEP		Rat	PMID:10342836|RGD:7349386
Biological Process	GO:0032570	response to progesterone	Gjb2	IEP		Rat	PMID:8612484|RGD:11568660
Biological Process	GO:0032526	response to retinoic acid	Gjb2	IEP		Rat	PMID:9570757|RGD:11568675
Biological Process	GO:0055085	transmembrane transport	GJB2	IDA		Human	PMID:12767933

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern