Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GJB6
  • Mouse genes Gjb6
  • Rat genes Gjb6
  • Zfish genes gjb8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gjb6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	GJB6	IDA		Human	PMID:19285977
Molecular Function	GO:0048487	beta-tubulin binding	GJB6	IDA		Human	PMID:19285977
Molecular Function	GO:0005243	gap junction channel activity	GJB6	IDA		Human	PMID:12767933
Molecular Function	GO:0005243	gap junction channel activity	gjb8	IDA		Zfish	PMID:20737512
Molecular Function	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling	GJB6	IDA		Human	PMID:12767933
Molecular Function	GO:0008017	microtubule binding	GJB6	IDA		Human	PMID:19285977
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:A2RU14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:O75396	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:P26715	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q96IW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q9BZJ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GJB6	IPI	UniProtKB:Q9H2L4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gjb6	IPI	UniProtKB:P39447	Mouse	MGI:MGI:5508268|PMID:16045494
Molecular Function	GO:0005515	protein binding	Gjb6	IPI	PR:Q00977	Mouse	PMID:14595769
Cellular Component	GO:0005884	actin filament	GJB6	IMP		Human	PMID:19285977
Cellular Component	GO:0016324	apical plasma membrane	Gjb6	IDA		Rat	PMID:16077080|RGD:1599830
Cellular Component	GO:0030054	cell junction	GJB6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Gjb6	IDA		Rat	PMID:16077080|RGD:1599830
Cellular Component	GO:0005921	gap junction	GJB6	IMP		Human	PMID:19285977
Cellular Component	GO:0005921	gap junction	Gjb6	IDA		Mouse	PMID:20089884
Cellular Component	GO:0005921	gap junction	Gjb6	IDA		Mouse	PMID:24590285
Cellular Component	GO:0005921	gap junction	Gjb6	IDA		Mouse	PMID:14595769
Cellular Component	GO:0005921	gap junction	Gjb6	IDA		Rat	PMID:10197766|RGD:1599836
Cellular Component	GO:0005921	gap junction	Gjb6	IDA		Rat	PMID:12064610|RGD:632752
Biological Process	GO:0007568	aging	Gjb6	IEP		Rat	PMID:23516399|RGD:7364768
Biological Process	GO:0006915	apoptotic process	Gjb6	IEP		Rat	PMID:12359154|RGD:632751
Biological Process	GO:0071333	cellular response to glucose stimulus	Gjb6	IEP		Rat	PMID:21567444|RGD:7364783
Biological Process	GO:0042471	ear morphogenesis	Gjb6	IMP	MGI:MGI:2447863	Mouse	PMID:12490528
Biological Process	GO:0016264	gap junction assembly	GJB6	IMP		Human	PMID:19285977
Biological Process	GO:1990349	gap junction-mediated intercellular transport	GJB6	IDA		Human	PMID:12767933
Biological Process	GO:0048839	inner ear development	Gjb6	IEP		Rat	PMID:10570462|RGD:1599834
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-GENO-230301-6	Zfish	PMID:32455934
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-GENO-230301-5	Zfish	PMID:32455934
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-MRPHLNO-140708-4	Zfish	PMID:24811980
Biological Process	GO:0048839	inner ear development	gjb8	IMP	ZFIN:ZDB-MRPHLNO-140708-5	Zfish	PMID:24811980
Biological Process	GO:0008285	negative regulation of cell population proliferation	Gjb6	IDA		Rat	PMID:11238193|RGD:1599833
Biological Process	GO:0051602	response to electrical stimulus	Gjb6	IEP		Rat	PMID:23149765|RGD:7364770
Biological Process	GO:0032496	response to lipopolysaccharide	Gjb6	IEP		Rat	PMID:23023213|RGD:7364771
Biological Process	GO:0007605	sensory perception of sound	Gjb6	IMP	MGI:MGI:2447863	Mouse	PMID:12490528
Biological Process	GO:0055085	transmembrane transport	GJB6	IDA		Human	PMID:12767933

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern