Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLA
  • Mouse genes Gla
  • Rat genes Gla
  • Zfish genes gla
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gla

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004557	alpha-galactosidase activity	GLA	IMP		Human	PMID:16372133
Molecular Function	GO:0004557	alpha-galactosidase activity	GLA	IDA		Human	PMID:27211852
Molecular Function	GO:0004557	alpha-galactosidase activity	GLA	IDA		Human	PMID:39940
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:2890215
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:6251472
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:1008807
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:6852525
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:198184
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:895843
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:205481
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:10840053
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:2906327
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:11115376
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IMP	MGI:MGI:1861794	Mouse	PMID:9122231
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Mouse	PMID:15629890
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IDA		Rat	PMID:8702598|RGD:1625498
Molecular Function	GO:0004557	alpha-galactosidase activity	Gla	IMP		Rat	PMID:8717430|RGD:1625507
Molecular Function	GO:0003824	catalytic activity	GLA	IDA		Human	PMID:39940
Molecular Function	GO:0016936	galactoside binding	Gla	IDA		Rat	PMID:8702598|RGD:1625498
Molecular Function	GO:0017041	galactosylgalactosylglucosylceramidase activity	GLA	IMP		Human	PMID:10838196
Molecular Function	GO:0017041	galactosylgalactosylglucosylceramidase activity	GLA	IDA		Human	PMID:8804427
Molecular Function	GO:0016787	hydrolase activity	Gla	IDA		Mouse	PMID:19710420
Molecular Function	GO:0005515	protein binding	GLA	IPI	UniProtKB:P08169	Human	PMID:1332979
Molecular Function	GO:0005515	protein binding	GLA	IPI	UniProtKB:Q99523	Human	PMID:21949853
Molecular Function	GO:0005515	protein binding	GLA	IPI	UniProtKB:P81460	Human	PMID:6313412
Molecular Function	GO:0042803	protein homodimerization activity	GLA	IDA		Human	PMID:6256390
Molecular Function	GO:0005102	signaling receptor binding	GLA	IDA		Human	PMID:1332979
Cellular Component	GO:0005737	cytoplasm	GLA	IMP		Human	PMID:1332979
Cellular Component	GO:0070062	extracellular exosome	GLA	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	GLA	IMP		Human	PMID:1332979
Cellular Component	GO:0005576	extracellular region	GLA	IDA		Human	PMID:3029062
Cellular Component	GO:0005615	extracellular space	Gla	IDA		Mouse	PMID:19710420
Cellular Component	GO:0005794	Golgi apparatus	GLA	IMP		Human	PMID:1332979
Cellular Component	GO:0005764	lysosome	GLA	IMP		Human	PMID:1332979
Cellular Component	GO:0005764	lysosome	Gla	IDA		Mouse	PMID:15629890
Cellular Component	GO:0005764	lysosome	Gla	IDA		Rat	PMID:8702598|RGD:1625498
Biological Process	GO:0035904	aorta development	Gla	IMP	MGI:MGI:1861794	Mouse	PMID:32428018
Biological Process	GO:0046479	glycosphingolipid catabolic process	GLA	IMP		Human	PMID:10838196
Biological Process	GO:0046479	glycosphingolipid catabolic process	GLA	IDA		Human	PMID:8804427
Biological Process	GO:0046477	glycosylceramide catabolic process	Gla	IMP	MGI:MGI:1861794	Mouse	PMID:10841515
Biological Process	GO:0046477	glycosylceramide catabolic process	Gla	IMP	MGI:MGI:1861794	Mouse	PMID:9122231
Biological Process	GO:0046477	glycosylceramide catabolic process	Gla	IMP	MGI:MGI:1861794	Mouse	PMID:11752062
Biological Process	GO:0046477	glycosylceramide catabolic process	Gla	IDA		Mouse	PMID:10840053
Biological Process	GO:0046477	glycosylceramide catabolic process	Gla	IDA		Mouse	PMID:15629890
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Gla	IMP		Mouse	MGI:MGI:3624267|PMID:15668341
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	Gla	IMP		Mouse	MGI:MGI:3624267|PMID:15668341
Biological Process	GO:0009311	oligosaccharide metabolic process	GLA	IDA		Human	PMID:39940

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern