Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gli1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GLI1
- Mouse genes Gli1
- Rat genes Gli1
- Zfish genes gli1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gli1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Gli1	IDA		Mouse	PMID:16396903
Molecular Function	GO:0003682	chromatin binding	Gli1	IDA		Mouse	PMID:17442700
Molecular Function	GO:0003677	DNA binding	GLI1	IDA		Human	PMID:9118802
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Gli1	IDA		Mouse	PMID:17442700
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	gli1	IDA		Zfish	PMID:29719254
Molecular Function	GO:0008017	microtubule binding	Gli1	IDA		Mouse	PMID:11717126
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1-1	Human	PMID:10564661
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1-2	Human	PMID:10564661
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P46684	Human	PMID:11238441
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q96J02	Human	PMID:20818436
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9QZS3-2	Human	PMID:20818436
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P23443	Human	PMID:22439934
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P23443-2	Human	PMID:22439934
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:22439934
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P40337-1	Human	PMID:23395608
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P40337-3	Human	PMID:23395608
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:24217340
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:24311597
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P54646	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q8IWZ5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q96CN9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P53673	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:28965847
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q8NEC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLI1	IPI	UniProtKB:Q9UMX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gli1	IPI	UniProtKB:Q2M1P5	Mouse	MGI:MGI:4359116\|PMID:19592253
Molecular Function	GO:0005515	protein binding	Gli1	IPI	PR:Q9Z0P7	Mouse	PMID:10920228
Molecular Function	GO:0005515	protein binding	Gli1	IPI	PR:Q9Z0P7	Mouse	PMID:10531011
Molecular Function	GO:0005515	protein binding	gli1	IPI	RefSeq:NP_001014816	Zfish	PMID:15647323
Molecular Function	GO:0005515	protein binding	gli1	IPI	UniProtKB:Q7ZVZ9	Zfish	PMID:15647323
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gli1	IDA		Mouse	PMID:23740243
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gli1	IDA		Mouse	PMID:15614767
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	GLI1	IDA		Human	PMID:18298960
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GLI1	IDA		Human	PMID:17035233
Cellular Component	GO:0005930	axoneme	Gli1	IDA		Mouse	MGI:MGI:3692156\|PMID:16254602
Cellular Component	GO:0000785	chromatin	gli1	IDA		Zfish	PMID:29719254
Cellular Component	GO:0005929	cilium	Gli1	IDA		Mouse	PMID:16254602
Cellular Component	GO:0005929	cilium	Gli1	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005737	cytoplasm	GLI1	IDA		Human	PMID:24076122
Cellular Component	GO:0005737	cytoplasm	GLI1	IDA		Human	PMID:10504446
Cellular Component	GO:0005737	cytoplasm	GLI1	IDA		Human	PMID:11238441
Cellular Component	GO:0005737	cytoplasm	GLI1	IDA		Human	PMID:16229683
Cellular Component	GO:0005737	cytoplasm	GLI1	IDA		Human	PMID:19878745
Cellular Component	GO:0005737	cytoplasm	Gli1	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005737	cytoplasm	Gli1	IDA		Mouse	PMID:11821712
Cellular Component	GO:0005737	cytoplasm	Gli1	IDA		Mouse	PMID:11717126
Cellular Component	GO:0005737	cytoplasm	Gli1	IGI	MGI:MGI:1345643	Mouse	PMID:16316410
Cellular Component	GO:0005829	cytosol	GLI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	GLI1	IDA		Human	PMID:18559511
Cellular Component	GO:1990788	GLI-SUFU complex	GLI1	IPI		Human	PMID:24311597
Cellular Component	GO:0035301	Hedgehog signaling complex	gli1	IDA		Zfish	PMID:15647323
Cellular Component	GO:0005654	nucleoplasm	GLI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GLI1	IDA		Human	PMID:10806483
Cellular Component	GO:0005634	nucleus	GLI1	IDA		Human	PMID:11238441
Cellular Component	GO:0005634	nucleus	GLI1	IDA		Human	PMID:19878745
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:16489008
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:17442700
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:16254602
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:11717126
Cellular Component	GO:0005634	nucleus	Gli1	IDA		Mouse	PMID:16316410
Biological Process	GO:0021560	abducens nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021742	abducens nucleus development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021984	adenohypophysis development	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:12620981
Biological Process	GO:0021984	adenohypophysis development	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:12606279
Biological Process	GO:0048855	adenohypophysis morphogenesis	gli1	IMP	ZFIN:ZDB-MRPHLNO-050209-5	Zfish	PMID:19056374
Biological Process	GO:0048855	adenohypophysis morphogenesis	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:19056374
Biological Process	GO:0007420	brain development	gli1	IMP	ZFIN:ZDB-MRPHLNO-050209-5	Zfish	PMID:12620981
Biological Process	GO:0007420	brain development	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:12620981
Biological Process	GO:0021696	cerebellar cortex morphogenesis	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:16571625
Biological Process	GO:0021545	cranial nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0009953	dorsal/ventral pattern formation	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:16342201
Biological Process	GO:0009913	epidermal cell differentiation	GLI1	IDA		Human	PMID:12165851
Biological Process	GO:0021561	facial nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021754	facial nucleus development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021508	floor plate formation	gli1	IMP	ZFIN:ZDB-GENO-980202-1208	Zfish	PMID:17045256
Biological Process	GO:0021508	floor plate formation	gli1	IGI	ZFIN:ZDB-GENO-070712-7	Zfish	PMID:12508225
Biological Process	GO:0048699	generation of neurons	gli1	IGI	ZFIN:ZDB-MRPHLNO-050209-7	Zfish	PMID:15890329
Biological Process	GO:0048699	generation of neurons	gli1	IMP	ZFIN:ZDB-GENO-980202-1208	Zfish	PMID:15890329
Biological Process	GO:0048699	generation of neurons	gli1	IGI	ZFIN:ZDB-MRPHLNO-050209-6	Zfish	PMID:15890329
Biological Process	GO:0021563	glossopharyngeal nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0097421	liver regeneration	Gli1	IMP	MGI:MGI:1857797	Mouse	PMID:23740243
Biological Process	GO:0097421	liver regeneration	Gli1	IEP		Rat	PMID:22024090\|RGD:12911223
Biological Process	GO:0097421	liver regeneration	Gli1	IEP		Rat	PMID:22790641\|RGD:12832760
Biological Process	GO:0030324	lung development	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:10725236
Biological Process	GO:0042694	muscle cell fate specification	gli1	IGI	ZFIN:ZDB-GENO-140627-1	Zfish	PMID:24244857
Biological Process	GO:0042694	muscle cell fate specification	gli1	IGI	ZFIN:ZDB-GENO-140717-8,ZFIN:ZDB-GENO-980202-876	Zfish	PMID:24244857
Biological Process	GO:0042694	muscle cell fate specification	gli1	IGI	ZFIN:ZDB-GENO-140718-3	Zfish	PMID:24244857
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	GLI1	IMP		Human	PMID:17035233
Biological Process	GO:1990787	negative regulation of hh target transcription factor activity	GLI1	IDA		Human	PMID:24311597
Biological Process	GO:0021532	neural tube patterning	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:24244857
Biological Process	GO:0021532	neural tube patterning	gli1	IGI	ZFIN:ZDB-GENO-140717-8,ZFIN:ZDB-GENO-980202-876	Zfish	PMID:24244857
Biological Process	GO:0030182	neuron differentiation	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:13129844
Biological Process	GO:0060032	notochord regression	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:10725236
Biological Process	GO:0042476	odontogenesis	gli1	IMP	ZFIN:ZDB-GENO-980202-1209	Zfish	PMID:22253766
Biological Process	GO:0001649	osteoblast differentiation	GLI1	IDA		Human	PMID:12165851
Biological Process	GO:0021983	pituitary gland development	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:10725236
Biological Process	GO:0021983	pituitary gland development	gli1	IMP		Zfish	PMID:12710963
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	GLI1	IDA		Human	PMID:28583401
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	GLI1	IDA		Human	PMID:28583401
Biological Process	GO:0008284	positive regulation of cell population proliferation	GLI1	IMP		Human	PMID:12165851
Biological Process	GO:0045740	positive regulation of DNA replication	GLI1	IDA		Human	PMID:12165851
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GLI1	IDA		Human	PMID:11238441
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GLI1	IDA		Human	PMID:12165851
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	GLI1	IDA		Human	PMID:17035233
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gli1	IMP		Mouse	MGI:MGI:4835146\|PMID:17035233
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gli1	IDA		Mouse	MGI:MGI:3692156\|PMID:16254602
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gli1	IDA		Mouse	PMID:15614767
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Gli1	IDA		Mouse	PMID:16936075
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	GLI1	IDA		Human	PMID:17035233
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	gli1	IGI	ZFIN:ZDB-GENO-110203-15,ZFIN:ZDB-MRPHLNO-050209-5	Zfish	PMID:19700616
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GLI1	IDA		Human	PMID:10693759
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GLI1	IDA		Human	PMID:9118802
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GLI1	IDA		Human	PMID:12165851
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GLI1	IDA		Human	PMID:24076122
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gli1	IDA		Mouse	PMID:16611981
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gli1	IDA		Mouse	PMID:23740243
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gli1	IDA		Mouse	PMID:17442700
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	gli1	IMP	ZFIN:ZDB-MRPHLNO-180830-9	Zfish	PMID:29719254
Biological Process	GO:0030850	prostate gland development	Gli1	IEP		Rat	PMID:15328011\|RGD:1303367
Biological Process	GO:0009954	proximal/distal pattern formation	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:16342201
Biological Process	GO:0006355	regulation of DNA-templated transcription	gli1	IDA		Zfish	PMID:12620981
Biological Process	GO:2000345	regulation of hepatocyte proliferation	Gli1	IMP		Mouse	PMID:23740243
Biological Process	GO:0050767	regulation of neurogenesis	gli1	IGI	ZFIN:ZDB-GENO-980202-1526	Zfish	PMID:15890329
Biological Process	GO:0050767	regulation of neurogenesis	gli1	IMP	ZFIN:ZDB-MRPHLNO-050209-5	Zfish	PMID:18725518
Biological Process	GO:0045667	regulation of osteoblast differentiation	Gli1	IMP		Mouse	MGI:MGI:5429486\|PMID:22493482
Biological Process	GO:0009611	response to wounding	Gli1	IMP	MGI:MGI:1857797	Mouse	PMID:23740243
Biological Process	GO:0009611	response to wounding	Gli1	IDA		Mouse	PMID:23740243
Biological Process	GO:0031290	retinal ganglion cell axon guidance	gli1	IMP	ZFIN:ZDB-GENO-980202-1208	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	gli1	IMP	ZFIN:ZDB-GENO-980202-1209	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	gli1	IMP	ZFIN:ZDB-GENO-980202-876	Zfish	PMID:9007260
Biological Process	GO:0007224	smoothened signaling pathway	GLI1	IDA		Human	PMID:19878745
Biological Process	GO:0007224	smoothened signaling pathway	GLI1	IDA		Human	PMID:31279575
Biological Process	GO:0007224	smoothened signaling pathway	Gli1	IDA		Mouse	PMID:23201751
Biological Process	GO:0007224	smoothened signaling pathway	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:18449196
Biological Process	GO:0007224	smoothened signaling pathway	Gli1	IDA		Mouse	PMID:19124651
Biological Process	GO:0007224	smoothened signaling pathway	Gli1	IDA		Mouse	PMID:9769173
Biological Process	GO:0007224	smoothened signaling pathway	gli1	IDA		Zfish	PMID:12620981
Biological Process	GO:0007224	smoothened signaling pathway	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:16571625
Biological Process	GO:0007286	spermatid development	Gli1	IEP		Rat	PMID:21893610\|RGD:150573809
Biological Process	GO:0007283	spermatogenesis	Gli1	IDA		Mouse	PMID:11717126
Biological Process	GO:0021731	trigeminal motor nucleus development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021559	trigeminal nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0021564	vagus nerve development	gli1	IMP		Zfish	PMID:10331983
Biological Process	GO:0007418	ventral midline development	Gli1	IGI	MGI:MGI:95728	Mouse	PMID:10725236
Biological Process	GO:0021521	ventral spinal cord interneuron specification	gli1	IMP	ZFIN:ZDB-GENO-980202-1208	Zfish	PMID:17045256

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.