Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLIS2
  • Mouse genes Glis2
  • Rat genes Glis2
  • Zfish genes glis2a,glis2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glis2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Glis2	IDA		Mouse	PMID:11262234
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P35222	Human	PMID:17289029
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:A1KXE4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:O15266-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:O43186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:O43482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:O75496	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P31321	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P53539	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P56545-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P56945	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P57052	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P61758	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P67870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P78424	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q03060-25	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q03989	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q08043	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q3LI72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q3SYF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q5BKX5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q6PJH3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q7Z4W3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q86WV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q86YR5-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q8IUC2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q8N2N9-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q8WVJ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q93062-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q9UF11-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q9UGI0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLIS2	IPI	UniProtKB:Q9Y5B8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Glis2	IPI	UniProtKB:Q9Z0P7	Mouse	MGI:MGI:5292436|PMID:21816948
Molecular Function	GO:0005515	protein binding	Glis2	IPI	PR:P30999	Mouse	PMID:17344476
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Glis2	IDA		Mouse	PMID:18298960
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GLIS2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Cellular Component	GO:0097730	non-motile cilium	Glis2	IDA		Mouse	PMID:17618285
Cellular Component	GO:0016607	nuclear speck	Glis2	IDA		Mouse	MGI:MGI:2176650|PMID:11741991
Cellular Component	GO:0005654	nucleoplasm	GLIS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Cellular Component	GO:0005634	nucleus	Glis2	IDA		Mouse	PMID:18227149
Biological Process	GO:0061005	cell differentiation involved in kidney development	Glis2	IMP	MGI:MGI:3719836	Mouse	PMID:17618285
Biological Process	GO:0003341	cilium movement	glis2b	IMP	ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24069149
Biological Process	GO:0060028	convergent extension involved in axis elongation	glis2b	IMP	ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24069149
Biological Process	GO:0001947	heart looping	glis2b	IMP	ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24069149
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Glis2	IMP		Mouse	PMID:26880577
Biological Process	GO:0001822	kidney development	Glis2	IMP	MGI:MGI:3785519	Mouse	PMID:18227149
Biological Process	GO:0060972	left/right pattern formation	glis2b	IMP	ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24069149
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Glis2	IDA		Mouse	MGI:MGI:2176650|PMID:11741991
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Glis2	IMP		Mouse	MGI:MGI:5292436|PMID:21816948
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis2	IMP	MGI:MGI:3719836	Mouse	PMID:17618285
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Glis2	IDA		Mouse	PMID:17618285
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Glis2	IDA		Mouse	MGI:MGI:2176650|PMID:11741991
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	Glis2	IGI	MGI:MGI:98397	Mouse	PMID:17344476
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Glis2	IDA		Mouse	MGI:MGI:4936785|PMID:21127075
Biological Process	GO:0039023	pronephric duct morphogenesis	glis2b	IGI	ZFIN:ZDB-MRPHLNO-060428-1,ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24500717
Biological Process	GO:0039023	pronephric duct morphogenesis	glis2b	IMP	ZFIN:ZDB-MRPHLNO-140131-2	Zfish	PMID:24500717
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Glis2	IMP	MGI:MGI:3785519	Mouse	PMID:18227149

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern