Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLRX
  • Mouse genes Glrx
  • Rat genes Glrx,Glrx-ps4
  • Zfish genes glrx
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glrx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015038	glutathione disulfide oxidoreductase activity	GLRX	EXP		Human	PMID:7851394
Molecular Function	GO:0015038	glutathione disulfide oxidoreductase activity	Glrx	IDA		Rat	PMID:12135599|RGD:9686047
Molecular Function	GO:0005515	protein binding	GLRX	IPI	UniProtKB:P35670	Human	PMID:16884690
Molecular Function	GO:0005515	protein binding	GLRX	IPI	UniProtKB:Q04656	Human	PMID:16884690
Molecular Function	GO:0005515	protein binding	GLRX	IPI	UniProtKB:Q9BVG3	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Glrx	IDA		Mouse	PMID:11213470
Cellular Component	GO:0005737	cytoplasm	Glrx	IDA		Rat	PMID:15956334|RGD:9686044
Cellular Component	GO:0005829	cytosol	Glrx	IDA		Rat	PMID:19299446|RGD:9686053
Cellular Component	GO:0030425	dendrite	Glrx	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0070062	extracellular exosome	GLRX	HDA		Human	PMID:18570454
Cellular Component	GO:0070062	extracellular exosome	GLRX	HDA		Human	PMID:19199708
Cellular Component	GO:0005758	mitochondrial intermembrane space	Glrx	IDA		Rat	PMID:17845131|RGD:9686049
Cellular Component	GO:0005739	mitochondrion	Glrx	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Glrx	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005634	nucleus	Glrx	IDA		Mouse	PMID:11213470
Cellular Component	GO:0005634	nucleus	Glrx	IDA		Rat	PMID:20620191|RGD:5133712
Biological Process	GO:0007568	aging	Glrx	IEP		Rat	PMID:20620191|RGD:5133712
Biological Process	GO:0007568	aging	Glrx	IEP		Rat	PMID:25126518|RGD:9686060
Biological Process	GO:0071392	cellular response to estradiol stimulus	Glrx	IDA		Rat	PMID:16549430|RGD:9686045
Biological Process	GO:0071333	cellular response to glucose stimulus	Glrx	IEP		Rat	PMID:17324929|RGD:9686046
Biological Process	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	Glrx	IMP		Rat	PMID:19938943|RGD:9686063
Biological Process	GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway	Glrx	IMP		Rat	PMID:16893901|RGD:9686048
Biological Process	GO:0022602	ovulation cycle process	Glrx	IEP		Rat	PMID:15956334|RGD:9686044
Biological Process	GO:0060355	positive regulation of cell adhesion molecule production	Glrx	IMP		Rat	PMID:17324929|RGD:9686046
Biological Process	GO:0045921	positive regulation of exocytosis	Glrx	IMP		Rat	PMID:19299446|RGD:9686053
Biological Process	GO:0032024	positive regulation of insulin secretion	Glrx	IMP		Rat	PMID:19299446|RGD:9686053
Biological Process	GO:0045838	positive regulation of membrane potential	GLRX	IDA		Human	PMID:19542013
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Glrx	IMP		Rat	PMID:19938943|RGD:9686063
Biological Process	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	GLRX	IDA		Human	PMID:19542013
Biological Process	GO:0002931	response to ischemia	Glrx	IEP		Rat	PMID:19938943|RGD:9686063
Biological Process	GO:0007584	response to nutrient	Glrx	IEP		Rat	PMID:18163565|RGD:2306160

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern