Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLRX2
  • Mouse genes Glrx2
  • Rat genes Glrx2
  • Zfish genes glrx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glrx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	glrx2	IDA		Zfish	PMID:23756812
Molecular Function	GO:0015038	glutathione disulfide oxidoreductase activity	glrx2	IDA		Zfish	PMID:23756812
Molecular Function	GO:0016491	oxidoreductase activity	glrx2	IDA		Zfish	PMID:22139372
Molecular Function	GO:0005515	protein binding	GLRX2	IPI	UniProtKB:Q7Z4W1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GLRX2	IPI	UniProtKB:Q9UKW6	Human	PMID:32296183
Molecular Function	GO:0015035	protein-disulfide reductase activity	Glrx2	IDA		Mouse	PMID:23872354
Cellular Component	GO:0005829	cytosol	glrx2	IDA		Zfish	PMID:22139372
Cellular Component	GO:0030425	dendrite	Glrx2	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GLRX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005759	mitochondrial matrix	Glrx2	IDA		Rat	PMID:17845131|RGD:9686049
Cellular Component	GO:0005739	mitochondrion	GLRX2	IDA		Human	PMID:11297543
Cellular Component	GO:0005739	mitochondrion	GLRX2	IDA		Human	PMID:11397793
Cellular Component	GO:0005739	mitochondrion	Glrx2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Glrx2	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005654	nucleoplasm	GLRX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GLRX2	IDA		Human	PMID:11297543
Cellular Component	GO:0005634	nucleus	Glrx2	IDA		Rat	PMID:20620191|RGD:5133712
Biological Process	GO:0007568	aging	Glrx2	IEP		Rat	PMID:20620191|RGD:5133712
Biological Process	GO:0007568	aging	Glrx2	IEP		Rat	PMID:25126518|RGD:9686060
Biological Process	GO:0071451	cellular response to superoxide	Glrx2	IEP		Rat	PMID:25126518|RGD:9686060
Biological Process	GO:0007417	central nervous system development	glrx2	IMP	ZFIN:ZDB-MRPHLNO-120127-9	Zfish	PMID:22139372
Biological Process	GO:0060914	heart formation	glrx2	IMP	ZFIN:ZDB-MRPHLNO-120127-9	Zfish	PMID:24944912
Biological Process	GO:0001755	neural crest cell migration	glrx2	IMP	ZFIN:ZDB-MRPHLNO-120127-9	Zfish	PMID:24944912
Biological Process	GO:0003147	neural crest cell migration involved in heart formation	glrx2	IMP	ZFIN:ZDB-MRPHLNO-120127-9	Zfish	PMID:24944912
Biological Process	GO:0080058	protein deglutathionylation	glrx2	IDA		Zfish	PMID:24277839
Biological Process	GO:0080058	protein deglutathionylation	glrx2	IDA		Zfish	PMID:24944912
Biological Process	GO:0042542	response to hydrogen peroxide	GLRX2	IDA		Human	PMID:11397793
Biological Process	GO:0010033	response to organic substance	GLRX2	IDA		Human	PMID:11397793
Biological Process	GO:0001944	vasculature development	glrx2	IMP	ZFIN:ZDB-MRPHLNO-120127-9	Zfish	PMID:24277839

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern