Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GLUD1,GLUD2
  • Mouse genes Glud1
  • Rat genes Glud1
  • Zfish genes glud1a,glud1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Glud1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	GLUD1	IDA		Human	PMID:12742085
Molecular Function	GO:0043531	ADP binding	GLUD2	IDA		Human	PMID:12742085
Molecular Function	GO:0019899	enzyme binding	Glud1	IPI	RGD:2016	Rat	PMID:1684101|RGD:2326092
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	GLUD1	IDA		Human	PMID:11903050
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	GLUD1	IDA		Human	PMID:15578726
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	GLUD2	IDA		Human	PMID:15578726
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	GLUD2	IDA		Human	PMID:8207021
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	Glud1	IDA		Mouse	MGI:MGI:4849622|PMID:20670938
Molecular Function	GO:0004352	glutamate dehydrogenase (NAD+) activity	Glud1	IDA		Rat	PMID:15273247|RGD:1601356
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	GLUD1	IDA		Human	PMID:11032875
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	GLUD2	IDA		Human	PMID:11032875
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Glud1	IDA		Mouse	MGI:MGI:5499916|PMID:23663782
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Glud1	IDA		Mouse	PMID:16959573
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Glud1	IDA		Mouse	PMID:26767982
Molecular Function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	Glud1	IDA		Mouse	PMID:11792727
Molecular Function	GO:0005525	GTP binding	GLUD1	IDA		Human	PMID:11032875
Molecular Function	GO:0005525	GTP binding	GLUD2	IDA		Human	PMID:11032875
Molecular Function	GO:0070728	leucine binding	GLUD1	IDA		Human	PMID:12742085
Molecular Function	GO:0070728	leucine binding	GLUD2	IDA		Human	PMID:12742085
Molecular Function	GO:0070403	NAD+ binding	GLUD1	IDA		Human	PMID:12193607
Molecular Function	GO:0005515	protein binding	GLUD1	IPI	UniProtKB:Q9Y6E7	Human	PMID:16959573
Molecular Function	GO:0005515	protein binding	Glud1	IPI	UniProtKB:Q61425	Mouse	MGI:MGI:4849622|PMID:20670938
Molecular Function	GO:0005515	protein binding	Glud1	IPI	PR:Q8R216	Mouse	PMID:16959573
Molecular Function	GO:0005515	protein binding	Glud1	IPI	PR:Q9QZL0	Mouse	PMID:19498109
Cellular Component	GO:0005737	cytoplasm	GLUD1	IDA		Human	PMID:18688271
Cellular Component	GO:0005783	endoplasmic reticulum	GLUD1	IDA		Human	PMID:19448744
Cellular Component	GO:0005743	mitochondrial inner membrane	Glud1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	Glud1	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	GLUD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	GLUD1	IDA		Human	PMID:15578726
Cellular Component	GO:0005739	mitochondrion	GLUD1	IDA		Human	PMID:19448744
Cellular Component	GO:0005739	mitochondrion	GLUD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	GLUD2	IDA		Human	PMID:18688271
Cellular Component	GO:0005739	mitochondrion	Glud1	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Glud1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Glud1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Glud1	IDA		Mouse	PMID:16959573
Cellular Component	GO:0005739	mitochondrion	Glud1	IDA		Rat	PMID:15273247|RGD:1601356
Biological Process	GO:0021549	cerebellum development	Glud1	IEP		Rat	PMID:7182074|RGD:10047093
Biological Process	GO:0006537	glutamate biosynthetic process	GLUD1	IDA		Human	PMID:11032875
Biological Process	GO:0006537	glutamate biosynthetic process	GLUD2	IDA		Human	PMID:11032875
Biological Process	GO:0006538	glutamate catabolic process	GLUD1	IDA		Human	PMID:11032875
Biological Process	GO:0006538	glutamate catabolic process	GLUD1	IDA		Human	PMID:6121377
Biological Process	GO:0006538	glutamate catabolic process	GLUD2	IDA		Human	PMID:11032875
Biological Process	GO:0006536	glutamate metabolic process	GLUD2	IDA		Human	PMID:8207021
Biological Process	GO:0006541	glutamine metabolic process	Glud1	IMP		Mouse	MGI:MGI:5499916|PMID:23663782
Biological Process	GO:0007616	long-term memory	Glud1	IEP		Rat	PMID:9275181|RGD:632875
Biological Process	GO:0032024	positive regulation of insulin secretion	GLUD1	IMP		Human	PMID:11502802
Biological Process	GO:0032024	positive regulation of insulin secretion	Glud1	IGI	MGI:MGI:1922637	Mouse	PMID:16959573
Biological Process	GO:0010044	response to aluminum ion	Glud1	IDA		Rat	PMID:10806405|RGD:6484591
Biological Process	GO:0021762	substantia nigra development	GLUD1	HEP		Human	PMID:22926577
Biological Process	GO:0072350	tricarboxylic acid metabolic process	Glud1	IMP		Mouse	MGI:MGI:5499916|PMID:23663782

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern