Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GNA12
  • Mouse genes Gna12
  • Rat genes Gna12
  • Zfish genes gna12a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gna12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031752	D5 dopamine receptor binding	Gna12	IPI	RGD:2523	Rat	PMID:12623966|RGD:730287
Molecular Function	GO:0005515	protein binding	GNA12	IPI	UniProtKB:O15085	Human	PMID:10026210
Molecular Function	GO:0005515	protein binding	GNA12	IPI	UniProtKB:Q8NE09	Human	PMID:18703424
Molecular Function	GO:0051721	protein phosphatase 2A binding	GNA12	IPI	UniProtKB:P30153	Human	PMID:15525651
Molecular Function	GO:0019888	protein phosphatase regulator activity	GNA12	IDA		Human	PMID:15525651
Cellular Component	GO:0031526	brush border membrane	Gna12	IDA		Rat	PMID:12623966|RGD:730287
Cellular Component	GO:0005925	focal adhesion	GNA12	HDA		Human	PMID:21423176
Cellular Component	GO:0016328	lateral plasma membrane	GNA12	IDA		Human	PMID:15525651
Cellular Component	GO:0043005	neuron projection	GNA12	IDA		Human	PMID:15525651
Cellular Component	GO:0043025	neuronal cell body	GNA12	IDA		Human	PMID:15525651
Biological Process	GO:0030154	cell differentiation	Gna12	IDA		Mouse	PMID:9305907
Biological Process	GO:0042074	cell migration involved in gastrulation	gna12a	IGI	ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:15928205
Biological Process	GO:0060973	cell migration involved in heart development	gna12a	IGI	ZFIN:ZDB-GENE-030131-5024,ZFIN:ZDB-GENE-030131-8277	Zfish	PMID:23318642
Biological Process	GO:0042733	embryonic digit morphogenesis	Gna12	IGI	MGI:MGI:95776	Mouse	PMID:12077299
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	gna12a	IGI	ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:19307601
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gna12	IMP		Rat	PMID:29453251|RGD:42721986
Biological Process	GO:0001702	gastrulation with mouth forming second	gna12a	IMP		Zfish	PMID:15928205
Biological Process	GO:0001702	gastrulation with mouth forming second	gna12a	IGI	ZFIN:ZDB-GENO-980202-187,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:15928205
Biological Process	GO:0001701	in utero embryonic development	Gna12	IGI	MGI:MGI:95768	Mouse	PMID:12077299
Biological Process	GO:0035556	intracellular signal transduction	Gna12	IDA		Mouse	PMID:10037795
Biological Process	GO:0048932	myelination of posterior lateral line nerve axons	gna12a	IGI	ZFIN:ZDB-GENO-180713-3,ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:29367382
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	gna12a	IGI	ZFIN:ZDB-GENO-100908-4,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:19307601
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	Gna12	IMP		Rat	PMID:29453251|RGD:42721986
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Gna12	IMP		Rat	PMID:29453251|RGD:42721986
Biological Process	GO:0014003	oligodendrocyte development	gna12a	IGI	ZFIN:ZDB-GENO-160202-2,ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:25607772
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	GNA12	IDA		Human	PMID:15525651
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	gna12a	IGI	ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:19307601
Biological Process	GO:0008217	regulation of blood pressure	Gna12	IGI	MGI:MGI:95768	Mouse	PMID:26531127
Biological Process	GO:0008360	regulation of cell shape	Gna12	IDA		Mouse	PMID:10037795
Biological Process	GO:0010762	regulation of fibroblast migration	Gna12	IMP		Mouse	MGI:MGI:5448916|PMID:22609986
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	GNA12	IMP		Human	PMID:22609986
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	Gna12	IMP		Mouse	MGI:MGI:5448916|PMID:22609986
Biological Process	GO:0032006	regulation of TOR signaling	GNA12	IMP		Human	PMID:22609986
Biological Process	GO:0032006	regulation of TOR signaling	Gna12	IMP		Mouse	MGI:MGI:5448916|PMID:22609986
Biological Process	GO:0009410	response to xenobiotic stimulus	Gna12	IEP		Rat	PMID:12623966|RGD:730287
Biological Process	GO:0007266	Rho protein signal transduction	Gna12	IDA		Mouse	PMID:10037795
Biological Process	GO:0007266	Rho protein signal transduction	gna12a	IMP		Zfish	PMID:15928205
Biological Process	GO:0043149	stress fiber assembly	gna12a	IMP		Zfish	PMID:15928205
Biological Process	GO:0009826	unidimensional cell growth	gna12a	IGI	ZFIN:ZDB-MRPHLNO-060113-1,ZFIN:ZDB-MRPHLNO-060113-3,ZFIN:ZDB-MRPHLNO-060113-4	Zfish	PMID:15928205

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern