Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GNAI1
  • Mouse genes Gnai1
  • Rat genes Gnai1
  • Zfish genes gnai1,gnaia
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gnai1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	Gnai1	IDA		Rat	PMID:25037222|RGD:10449515
Molecular Function	GO:0031821	G protein-coupled serotonin receptor binding	Gnai1	IPI	RGD:2845	Rat	PMID:16772521|RGD:2303642
Molecular Function	GO:0019003	GDP binding	Gnai1	IDA		Rat	PMID:19703466|RGD:10449520
Molecular Function	GO:0019003	GDP binding	Gnai1	IDA		Rat	PMID:8073283|RGD:12792992
Molecular Function	GO:0019003	GDP binding	Gnai1	IMP		Rat	PMID:8939752|RGD:12792995
Molecular Function	GO:0019003	GDP binding	Gnai1	IDA		Rat	PMID:9108480|RGD:7207370
Molecular Function	GO:0005525	GTP binding	GNAI1	IDA		Human	PMID:34685729
Molecular Function	GO:0005525	GTP binding	Gnai1	IDA		Rat	PMID:19703466|RGD:10449520
Molecular Function	GO:0005525	GTP binding	Gnai1	IDA		Rat	PMID:25037222|RGD:10449515
Molecular Function	GO:0005525	GTP binding	Gnai1	IMP		Rat	PMID:8073283|RGD:12792992
Molecular Function	GO:0005525	GTP binding	Gnai1	IMP		Rat	PMID:8939752|RGD:12792995
Molecular Function	GO:0032794	GTPase activating protein binding	Gnai1	IDA		Rat	PMID:9108480|RGD:7207370
Molecular Function	GO:0003924	GTPase activity	Gnai1	IDA		Rat	PMID:21158412|RGD:8553612
Molecular Function	GO:0003924	GTPase activity	Gnai1	IMP		Rat	PMID:8939752|RGD:12792995
Molecular Function	GO:0000287	magnesium ion binding	Gnai1	IDA		Rat	PMID:19703466|RGD:10449520
Molecular Function	GO:0000287	magnesium ion binding	Gnai1	IMP		Rat	PMID:8073283|RGD:12792992
Molecular Function	GO:0000287	magnesium ion binding	Gnai1	IMP		Rat	PMID:8939752|RGD:12792995
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:P81274	Human	PMID:15537540
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q14980	Human	PMID:15537540
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q08116	Human	PMID:18434541
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q8VDU0	Human	PMID:22952234
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q9UGC6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q9Y4H4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q8IVA1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GNAI1	IPI	UniProtKB:Q9Y4H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	PR:Q80TL4	Mouse	PMID:25242222
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:O08773	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:O08774	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	RGD:727957	Rat	PMID:12509430|RGD:633903
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:O08773	Rat	PMID:16870394|RGD:8553973
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:P97492	Rat	PMID:17635935|RGD:8553256
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:O08773	Rat	PMID:21158412|RGD:8553612
Molecular Function	GO:0005515	protein binding	Gnai1	IPI	UniProtKB:Q80ZG1	Rat	PMID:21158412|RGD:8553612
Cellular Component	GO:0005938	cell cortex	GNAI1	IDA		Human	PMID:23870127
Cellular Component	GO:0099738	cell cortex region	GNAI1	IDA		Human	PMID:22327364
Cellular Component	GO:0005813	centrosome	GNAI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	GNAI1	IDA		Human	PMID:17635935
Cellular Component	GO:0005813	centrosome	Gnai1	IDA		Rat	PMID:17635935|RGD:8553256
Cellular Component	GO:0005737	cytoplasm	GNAI1	IDA		Human	PMID:17635935
Cellular Component	GO:0005737	cytoplasm	Gnai1	IDA		Rat	PMID:17635935|RGD:8553256
Cellular Component	GO:0070062	extracellular exosome	GNAI1	HDA		Human	PMID:19056867
Cellular Component	GO:0005622	intracellular anatomical structure	Gnai1	IDA		Mouse	PMID:16805845
Cellular Component	GO:0005765	lysosomal membrane	GNAI1	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	Gnai1	IDA		Rat	PMID:16741924|RGD:2312769
Cellular Component	GO:0045121	membrane raft	Gnai1	IDA		Rat	PMID:17157995|RGD:1625132
Cellular Component	GO:0030496	midbody	GNAI1	IDA		Human	PMID:17635935
Cellular Component	GO:0005730	nucleolus	GNAI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GNAI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GNAI1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	GNAI1	IDA		Human	PMID:17635935
Cellular Component	GO:0005886	plasma membrane	GNAI1	IDA		Human	PMID:23027904
Cellular Component	GO:0005886	plasma membrane	GNAI1	IDA		Human	PMID:26766442
Cellular Component	GO:0005886	plasma membrane	Gnai1	IDA		Rat	PMID:16870394|RGD:8553973
Cellular Component	GO:0005886	plasma membrane	Gnai1	IDA		Rat	PMID:17635935|RGD:8553256
Cellular Component	GO:0005886	plasma membrane	Gnai1	IDA		Rat	PMID:21158412|RGD:8553612
Cellular Component	GO:0032991	protein-containing complex	Gnai1	IDA		Rat	PMID:9108480|RGD:7207370
Biological Process	GO:0051301	cell division	GNAI1	IMP		Human	PMID:17635935
Biological Process	GO:1904322	cellular response to forskolin	Gnai1	IMP		Rat	PMID:19703466|RGD:10449520
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gnai1	IMP		Rat	PMID:11923410|RGD:625670
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gnai1	IDA		Rat	PMID:25037222|RGD:10449515
Biological Process	GO:0050805	negative regulation of synaptic transmission	Gnai1	IMP		Rat	PMID:11923410|RGD:625670
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	GNAI1	IMP		Human	PMID:22327364
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	GNAI1	IMP		Human	PMID:23027904
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	GNAI1	IMP		Human	PMID:26766442
Biological Process	GO:0043949	regulation of cAMP-mediated signaling	Gnai1	IMP		Rat	PMID:19703466|RGD:10449520
Biological Process	GO:0060236	regulation of mitotic spindle organization	GNAI1	IMP		Human	PMID:23027904

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern