Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GNAQ
  • Mouse genes Gnaq
  • Rat genes Gnaq
  • Zfish genes gnaq
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gnaq

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	Gnaq	IDA		Rat	PMID:21812758|RGD:10448949
Molecular Function	GO:0003925	G protein activity	Gnaq	IMP		Mouse	PMID:26075576
Molecular Function	GO:0005096	GTPase activator activity	GNAQ	IDA		Human	PMID:15611106
Molecular Function	GO:0016004	phospholipase activator activity	Gnaq	IMP		Mouse	PMID:26075576
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:P16284	Human	PMID:18672896
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:Q969F8	Human	PMID:18772143
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:P10276	Human	PMID:22056876
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:Q8R455	Human	PMID:22750945
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:P49407	Human	PMID:23353685
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:Q5SSG4	Human	PMID:23994616
Molecular Function	GO:0005515	protein binding	GNAQ	IPI	UniProtKB:Q6DN90	Human	PMID:27265506
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:Q01970	Mouse	MGI:MGI:5915907|PMID:23377541
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:P41220	Mouse	MGI:MGI:5706915|PMID:19478087
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:P31016|UniProtKB:P39087|UniProtKB:Q61626	Mouse	MGI:MGI:3690189|PMID:16354929
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:O08915	Mouse	MGI:MGI:5508585|PMID:19390533
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:P41220-1	Mouse	MGI:MGI:5915358|PMID:23434405
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	UniProtKB:Q01970	Mouse	MGI:MGI:5914607|PMID:21822282
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	PR:Q8VHN7	Mouse	PMID:24191038
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	PR:Q61616	Mouse	PMID:9016340
Molecular Function	GO:0005515	protein binding	Gnaq	IPI	RGD:727957	Rat	PMID:12509430|RGD:633903
Molecular Function	GO:0044877	protein-containing complex binding	Gnaq	IPI	RGD:61276|RGD:619749	Rat	PMID:20548297|RGD:5491170
Cellular Component	GO:0005901	caveola	Gnaq	IDA		Rat	PMID:16730745|RGD:1598488
Cellular Component	GO:0044297	cell body	Gnaq	IDA		Mouse	PMID:11685543
Cellular Component	GO:0005829	cytosol	Gnaq	IDA		Rat	PMID:14534355|RGD:1601365
Cellular Component	GO:0005829	cytosol	Gnaq	IDA		Rat	PMID:15175423|RGD:5133684
Cellular Component	GO:0030425	dendrite	Gnaq	IDA		Mouse	PMID:11685543
Cellular Component	GO:0070062	extracellular exosome	GNAQ	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	GNAQ	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	GNAQ	HDA		Human	PMID:23533145
Cellular Component	GO:0005834	heterotrimeric G-protein complex	Gnaq	IDA		Rat	PMID:21812758|RGD:10448949
Cellular Component	GO:0005765	lysosomal membrane	GNAQ	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	Gnaq	IDA		Mouse	PMID:9016340
Cellular Component	GO:0005886	plasma membrane	Gnaq	IDA		Mouse	PMID:9765251
Cellular Component	GO:0005886	plasma membrane	Gnaq	IDA		Rat	PMID:14534355|RGD:1601365
Cellular Component	GO:0005886	plasma membrane	Gnaq	IDA		Rat	PMID:15175423|RGD:5133684
Cellular Component	GO:0045202	synapse	Gnaq	IDA		Rat	PMID:10212487|RGD:2302006
Biological Process	GO:0001508	action potential	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:10818132
Biological Process	GO:0007202	activation of phospholipase C activity	Gnaq	IMP		Rat	PMID:14981460|RGD:1598489
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnaq	IDA		Mouse	PMID:10481072
Biological Process	GO:1904888	cranial skeletal system development	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:18199583
Biological Process	GO:1904888	cranial skeletal system development	Gnaq	IGI	MGI:MGI:95776	Mouse	PMID:18199583
Biological Process	GO:0048066	developmental pigmentation	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:15322542
Biological Process	GO:0042733	embryonic digit morphogenesis	Gnaq	IGI	MGI:MGI:95767	Mouse	PMID:12077299
Biological Process	GO:0086100	endothelin receptor signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:18199583
Biological Process	GO:0021884	forebrain neuron development	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:15340067
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:9687499
Biological Process	GO:0007215	glutamate receptor signaling pathway	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:11438569
Biological Process	GO:0007507	heart development	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:9687499
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:20440069
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Gnaq	IMP		Mouse	PMID:26075576
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:20440069
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Gnaq	IMP		Mouse	PMID:26075576
Biological Process	GO:0042711	maternal behavior	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:15340067
Biological Process	GO:0043066	negative regulation of apoptotic process	Gnaq	IMP		Rat	PMID:16466740|RGD:1581905
Biological Process	GO:0043267	negative regulation of potassium ion transport	Gnaq	IMP		Rat	PMID:9614229|RGD:1598491
Biological Process	GO:0006469	negative regulation of protein kinase activity	GNAQ	IMP		Human	PMID:20399743
Biological Process	GO:0016322	neuron remodeling	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:9391157
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	Gnaq	IGI	MGI:MGI:94924	Mouse	PMID:17194762
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:17194762
Biological Process	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	Gnaq	IGI	MGI:MGI:99578	Mouse	PMID:17194762
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:20440069
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Gnaq	IGI	MGI:MGI:95776	Mouse	PMID:20440069
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:20440069
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Gnaq	IMP		Mouse	PMID:26075576
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Gnaq	IMP		Rat	PMID:9677408|RGD:1598490
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:20440069
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnaq	IGI	MGI:MGI:95776	Mouse	PMID:20440069
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnaq	IMP		Mouse	PMID:26075576
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Gnaq	IMP		Rat	PMID:14981460|RGD:1598489
Biological Process	GO:0009791	post-embryonic development	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:15340067
Biological Process	GO:0050821	protein stabilization	GNAQ	IMP		Human	PMID:20399743
Biological Process	GO:0008217	regulation of blood pressure	Gnaq	IGI	MGI:MGI:95766	Mouse	PMID:26531127
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	GNAQ	IMP		Human	PMID:20399743
Biological Process	GO:0045634	regulation of melanocyte differentiation	Gnaq	IMP	MGI:MGI:2681766	Mouse	PMID:15322542
Biological Process	GO:0010543	regulation of platelet activation	Gnaq	IMP		Mouse	MGI:MGI:1096702|PMID:9296496
Biological Process	GO:0001501	skeletal system development	Gnaq	IMP	MGI:MGI:2151661	Mouse	PMID:9687499

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern