Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GNAS
  • Mouse genes Gnas
  • Rat genes Gnas
  • Zfish genes gnas
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gnas

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010856	adenylate cyclase activator activity	Gnas	IDA		Mouse	PMID:17971513
Molecular Function	GO:0010856	adenylate cyclase activator activity	Gnas	IMP		Mouse	PMID:12145344
Molecular Function	GO:0010856	adenylate cyclase activator activity	Gnas	IDA		Rat	PMID:13680124|RGD:2312682
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	Gnas	IDA		Rat	PMID:21812758|RGD:10448949
Molecular Function	GO:0043014	alpha-tubulin binding	Gnas	IDA		Rat	PMID:17705289|RGD:5509865
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	Gnas	IPI	RGD:2060	Rat	PMID:19942860|RGD:4107483
Molecular Function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	Gnas	IPI	RGD:61276	Rat	PMID:20548297|RGD:5491170
Molecular Function	GO:0031748	D1 dopamine receptor binding	Gnas	IPI	RGD:2518	Rat	PMID:15798088|RGD:2302119
Molecular Function	GO:0003925	G protein activity	Gnas	IMP		Mouse	PMID:12145344
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Gnas	IPI	UniProtKB:Q63803	Rat	PMID:11447126|RGD:5509808
Molecular Function	GO:0031681	G-protein beta-subunit binding	Gnas	IDA		Rat	PMID:12486122|RGD:5509804
Molecular Function	GO:0005525	GTP binding	Gnas	IDA		Rat	PMID:21084061|RGD:5509805
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	Gnas	IPI	RGD:2869	Rat	PMID:19764351|RGD:5509824
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Gnas	IPI	RGD:621531	Rat	PMID:19942860|RGD:4107483
Molecular Function	GO:0031852	mu-type opioid receptor binding	Gnas	IDA		Rat	PMID:16967511|RGD:1601381
Molecular Function	GO:0031852	mu-type opioid receptor binding	Gnas	IPI	RGD:3234	Rat	PMID:19682558|RGD:5509825
Molecular Function	GO:0005515	protein binding	GNAS	IPI	UniProtKB:P84996	Human	PMID:12719376
Molecular Function	GO:0005515	protein binding	GNAS	IPI	UniProtKB:P49407	Human	PMID:23353685
Molecular Function	GO:0005515	protein binding	Gnas	IPI	PR:Q8VEC3	Mouse	PMID:27759003
Molecular Function	GO:0005515	protein binding	Gnas	IPI	PR:Q8VHN7	Mouse	PMID:24191038
Molecular Function	GO:0005515	protein binding	Gnas	IPI	PR:Q61616	Mouse	PMID:9016340
Molecular Function	GO:0005515	protein binding	Gnas	IPI	UniProtKB:Q9Z213	Rat	PMID:11447126|RGD:5509808
Molecular Function	GO:0005515	protein binding	Gnas	IPI	RGD:1306694	Rat	PMID:15749703|RGD:10401274
Molecular Function	GO:0005515	protein binding	Gnas	IPI	RGD:1316040	Rat	PMID:18034856|RGD:5509845
Molecular Function	GO:0019904	protein domain specific binding	Gnas	IPI	UniProtKB:Q63803	Rat	PMID:11447126|RGD:5509808
Cellular Component	GO:0030142	COPI-coated Golgi to ER transport vesicle	Gnas	IDA		Rat	PMID:15749703|RGD:10401274
Cellular Component	GO:0005737	cytoplasm	Gnas	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0005829	cytosol	GNAS	IDA		Human	PMID:12719376
Cellular Component	GO:0005829	cytosol	Gnas	IDA		Rat	PMID:19136528|RGD:5509835
Cellular Component	GO:0005829	cytosol	Gnas	IDA		Rat	PMID:9603988|RGD:8554017
Cellular Component	GO:0030425	dendrite	Gnas	IDA		Mouse	PMID:19966281
Cellular Component	GO:0005768	endosome	Gnas	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0070062	extracellular exosome	GNAS	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	GNAS	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	GNAS	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	Gnas	IDA		Rat	PMID:10749939|RGD:10401273
Cellular Component	GO:0005834	heterotrimeric G-protein complex	Gnas	IDA		Rat	PMID:15297467|RGD:1580407
Cellular Component	GO:0005834	heterotrimeric G-protein complex	Gnas	IDA		Rat	PMID:18403039|RGD:8553387
Cellular Component	GO:0016020	membrane	GNAS	IDA		Human	PMID:12719376
Cellular Component	GO:0016020	membrane	GNAS	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Gnas	IMP	MGI:MGI:2152744	Mouse	PMID:9322912
Cellular Component	GO:0016020	membrane	Gnas	IDA		Mouse	PMID:9016340
Cellular Component	GO:0016020	membrane	Gnas	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0016020	membrane	Gnas	IDA		Rat	PMID:9603988|RGD:8554017
Cellular Component	GO:0045121	membrane raft	Gnas	IDA		Rat	PMID:19996298|RGD:5509815
Cellular Component	GO:0043025	neuronal cell body	Gnas	IDA		Rat	PMID:18539096|RGD:10401272
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Gnas	IDA		Rat	PMID:15297467|RGD:1580407
Cellular Component	GO:0005886	plasma membrane	Gnas	IDA		Mouse	PMID:17971513
Cellular Component	GO:0005886	plasma membrane	Gnas	IDA		Rat	PMID:12614155|RGD:1358726
Cellular Component	GO:0005886	plasma membrane	Gnas	IDA		Rat	PMID:15297467|RGD:1580407
Cellular Component	GO:0005886	plasma membrane	Gnas	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0055037	recycling endosome	Gnas	IDA		Rat	PMID:15297467|RGD:1580407
Cellular Component	GO:0001726	ruffle	Gnas	IDA		Rat	PMID:11447126|RGD:5509808
Cellular Component	GO:0042383	sarcolemma	Gnas	IDA		Rat	PMID:15961389|RGD:1598749
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Gnas	IGI	MGI:MGI:95774	Mouse	PMID:17194762
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Gnas	IGI	MGI:MGI:99578	Mouse	PMID:17194762
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Gnas	IDA		Rat	PMID:18403039|RGD:8553387
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GNAS	IMP		Human	PMID:12719376
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IDA		Mouse	PMID:17971513
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IGI	MGI:MGI:95674	Mouse	PMID:33196462
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IMP	MGI:MGI:3609165	Mouse	PMID:34091063
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IMP		Mouse	PMID:3092218
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IMP		Mouse	PMID:2826231
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IMP	MGI:MGI:2152744	Mouse	PMID:9322912
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IDA		Mouse	PMID:2499043
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IMP		Rat	PMID:12486122|RGD:5509804
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IDA		Rat	PMID:15579502|RGD:2313211
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IDA		Rat	PMID:16967511|RGD:1601381
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gnas	IDA		Rat	PMID:17010343|RGD:2315004
Biological Process	GO:0060348	bone development	GNAS	IMP		Human	PMID:12719376
Biological Process	GO:0055074	calcium ion homeostasis	Gnas	IMP		Rat	PMID:21303955|RGD:6483786
Biological Process	GO:0051216	cartilage development	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0071870	cellular response to catecholamine stimulus	Gnas	IDA		Rat	PMID:18403039|RGD:8553387
Biological Process	GO:0071377	cellular response to glucagon stimulus	Gnas	IMP	MGI:MGI:3609165	Mouse	PMID:16239968
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	Gnas	IDA		Rat	PMID:18403039|RGD:8553387
Biological Process	GO:0048589	developmental growth	GNAS	IMP		Human	PMID:12719376
Biological Process	GO:0006306	DNA methylation	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0001958	endochondral ossification	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0006112	energy reserve metabolic process	Gnas	IMP	MGI:MGI:2152743	Mouse	PMID:10712433
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gnas	IMP		Rat	PMID:15687107|RGD:1625210
Biological Process	GO:0071514	genomic imprinting	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744
Biological Process	GO:0035264	multicellular organism growth	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744
Biological Process	GO:0045776	negative regulation of blood pressure	Gnas	IMP		Rat	PMID:21895632|RGD:5509797
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Gnas	IMP		Mouse	MGI:MGI:5514285|PMID:23839232
Biological Process	GO:0035814	negative regulation of renal sodium excretion	Gnas	IMP		Rat	PMID:21895632|RGD:5509797
Biological Process	GO:0070527	platelet aggregation	GNAS	IMP		Human	PMID:12719376
Biological Process	GO:0008284	positive regulation of cell population proliferation	Gnas	IDA		Rat	PMID:17363453|RGD:10401271
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Gnas	IMP	UniProtKB:P63094,UniProtKB:Q6R0H6,UniProtKB:Q9Z0F1|UniProtKB:Q6R0H6,UniProtKB:Q6R0H7,UniProtKB:Q9Z0F1|UniProtKB:P63094,UniProtKB:Q6R0H7,UniProtKB:Q9Z0F1|UniProtKB:P63094,UniProtKB:Q6R0H6,UniProtKB:Q6R0H7	Mouse	MGI:MGI:4452162|PMID:20374964
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnas	IDA		Mouse	PMID:17971513
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnas	IGI	MGI:MGI:95674	Mouse	PMID:33196462
Biological Process	GO:0032024	positive regulation of insulin secretion	Gnas	IMP	MGI:MGI:3609165	Mouse	PMID:34091063
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gnas	IMP		Rat	PMID:21303955|RGD:6483786
Biological Process	GO:0010765	positive regulation of sodium ion transport	Gnas	IMP		Rat	PMID:10381586|RGD:5509841
Biological Process	GO:0040032	post-embryonic body morphogenesis	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0009791	post-embryonic development	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744
Biological Process	GO:0009791	post-embryonic development	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:2000828	regulation of parathyroid hormone secretion	Gnas	IMP	MGI:MGI:3043369	Mouse	PMID:15811946
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Gnas	IMP		Rat	PMID:20940042|RGD:6483811
Biological Process	GO:0009410	response to xenobiotic stimulus	Gnas	IMP	MGI:MGI:2152744	Mouse	PMID:11438605
Biological Process	GO:0001501	skeletal system development	Gnas	IMP	MGI:MGI:3043361	Mouse	PMID:15797856
Biological Process	GO:0043588	skin development	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744
Biological Process	GO:0001894	tissue homeostasis	Gnas	IMP	MGI:MGI:4459474	Mouse	PMID:20427744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern