Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPBAR1
  • Mouse genes Gpbar1
  • Rat genes Gpbar1
  • Zfish genes gpbar1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpbar1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038181	bile acid receptor activity	GPBAR1	IDA		Human	PMID:12419312
Molecular Function	GO:0038182	G protein-coupled bile acid receptor activity	GPBAR1	IDA		Human	PMID:12524422
Molecular Function	GO:0004930	G protein-coupled receptor activity	Gpbar1	IDA		Rat	PMID:12524422|RGD:634463
Cellular Component	GO:0005737	cytoplasm	GPBAR1	IDA		Human	PMID:12524422
Cellular Component	GO:0005886	plasma membrane	GPBAR1	IDA		Human	PMID:12419312
Cellular Component	GO:0005886	plasma membrane	GPBAR1	IDA		Human	PMID:12524422
Cellular Component	GO:0043235	receptor complex	GPBAR1	IDA		Human	PMID:12419312
Cellular Component	GO:0043235	receptor complex	GPBAR1	IDA		Human	PMID:12524422
Biological Process	GO:0038184	cell surface bile acid receptor signaling pathway	GPBAR1	IDA		Human	PMID:12419312
Biological Process	GO:0038184	cell surface bile acid receptor signaling pathway	GPBAR1	IDA		Human	PMID:12524422
Biological Process	GO:1903413	cellular response to bile acid	GPBAR1	IDA		Human	PMID:12419312
Biological Process	GO:1903413	cellular response to bile acid	GPBAR1	IDA		Human	PMID:12524422
Biological Process	GO:1904056	positive regulation of cholangiocyte proliferation	Gpbar1	IMP		Rat	PMID:28543567|RGD:14700993
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gpbar1	IMP		Rat	PMID:28543567|RGD:14700993
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	Gpbar1	IMP		Mouse	MGI:MGI:5297273|PMID:22046243

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern