Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPC3
  • Mouse genes Gpc3
  • Rat genes Gpc3
  • Zfish genes gpc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060422	peptidyl-dipeptidase inhibitor activity	GPC3	IDA		Human	PMID:17549790
Molecular Function	GO:0005515	protein binding	GPC3	IPI	UniProtKB:P27487	Human	PMID:17549790
Molecular Function	GO:0005515	protein binding	GPC3	IPI	UniProtKB:Q8N158,UniProtKB:Q96SN8,UniProtKB:Q9Y625	Human	PMID:29162697
Molecular Function	GO:0005515	protein binding	Gpc3	IPI	PR:Q62226	Mouse	PMID:18477453
Molecular Function	GO:0005515	protein binding	Gpc3	IPI	PR:P14142	Mouse	PMID:18343214
Cellular Component	GO:0005764	lysosome	Gpc3	IDA		Mouse	PMID:18477453
Cellular Component	GO:0005886	plasma membrane	GPC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Gpc3	IMP		Mouse	PMID:18477453
Cellular Component	GO:0005886	plasma membrane	Gpc3	IDA		Mouse	PMID:18343214
Cellular Component	GO:0005886	plasma membrane	Gpc3	IDA		Rat	PMID:7487896|RGD:13702227
Biological Process	GO:0009887	animal organ morphogenesis	Gpc3	IMP		Mouse	PMID:9853964
Biological Process	GO:0009948	anterior/posterior axis specification	Gpc3	IGI	MGI:MGI:88180	Mouse	PMID:10964473
Biological Process	GO:0010171	body morphogenesis	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:18477453
Biological Process	GO:0030282	bone mineralization	Gpc3	IMP	MGI:MGI:2159355	Mouse	PMID:15936336
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Gpc3	IGI	MGI:MGI:88177	Mouse	PMID:15925496
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Gpc3	IGI	MGI:MGI:894293	Mouse	PMID:15925496
Biological Process	GO:0060070	canonical Wnt signaling pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637
Biological Process	GO:0042074	cell migration involved in gastrulation	gpc3	IMP		Zfish	PMID:14610063
Biological Process	GO:0072111	cell proliferation involved in kidney development	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:11180950
Biological Process	GO:0072203	cell proliferation involved in metanephros development	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0060976	coronary vasculature development	Gpc3	IMP	MGI:MGI:2159355	Mouse	PMID:19733558
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Gpc3	IGI	MGI:MGI:88180	Mouse	PMID:10964473
Biological Process	GO:0050673	epithelial cell proliferation	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0040007	growth	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637
Biological Process	GO:0001822	kidney development	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0030324	lung development	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	Gpc3	IMP		Mouse	MGI:MGI:3583399|PMID:15925496
Biological Process	GO:0072180	mesonephric duct morphogenesis	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:11180950
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Gpc3	IDA		Rat	PMID:15537637|RGD:8554067
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	gpc3	IGI	ZFIN:ZDB-GENE-120807-2,ZFIN:ZDB-MRPHLNO-120724-1	Zfish	PMID:22669824
Biological Process	GO:0008285	negative regulation of cell population proliferation	Gpc3	IGI	MGI:MGI:88177	Mouse	PMID:15925496
Biological Process	GO:0008285	negative regulation of cell population proliferation	Gpc3	IGI	MGI:MGI:894293	Mouse	PMID:15925496
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0045926	negative regulation of growth	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637
Biological Process	GO:0045926	negative regulation of growth	Gpc3	IMP	MGI:MGI:2657134	Mouse	PMID:11846487
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Gpc3	IGI	MGI:MGI:96533	Mouse	PMID:19590577
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:18477453
Biological Process	GO:0030316	osteoclast differentiation	Gpc3	IMP	MGI:MGI:2159355	Mouse	PMID:15936336
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15925496
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	GPC3	IDA		Human	PMID:24496449
Biological Process	GO:0045807	positive regulation of endocytosis	Gpc3	IDA		Mouse	PMID:18477453
Biological Process	GO:0046326	positive regulation of glucose import	Gpc3	IDA		Mouse	PMID:18343214
Biological Process	GO:0045732	positive regulation of protein catabolic process	Gpc3	IDA		Mouse	PMID:18477453
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Gpc3	IMP	MGI:MGI:2159355	Mouse	PMID:19733558
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	Gpc3	IDA		Rat	PMID:15537637|RGD:8554067
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	Gpc3	IGI	UniProtKB:Q9QXQ7	Rat	PMID:15537637|RGD:8554067
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	GPC3	IDA		Human	PMID:14610063
Biological Process	GO:0040008	regulation of growth	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:10402475
Biological Process	GO:0040008	regulation of growth	Gpc3	IGI	MGI:MGI:96533	Mouse	PMID:19590577
Biological Process	GO:2000050	regulation of non-canonical Wnt signaling pathway	GPC3	IDA		Human	PMID:14610063
Biological Process	GO:0009617	response to bacterium	Gpc3	IEP		Mouse	PMID:23012479
Biological Process	GO:0007224	smoothened signaling pathway	Gpc3	IMP	MGI:MGI:2159355	Mouse	PMID:19733558
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Gpc3	IMP	MGI:MGI:2159356	Mouse	PMID:15537637

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern