Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPC4
  • Mouse genes Gpc4
  • Rat genes Gpc4
  • Zfish genes gpc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GPC4	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	gpc4	IPI	UniProtKB:Q9W6D9	Zfish	PMID:17322405
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Gpc4	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0009897	external side of plasma membrane	GPC4	IDA		Human	PMID:10585884
Cellular Component	GO:0070062	extracellular exosome	GPC4	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	Gpc4	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IDA		Mouse	PMID:23911103
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IMP		Mouse	PMID:23911103
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IDA		Rat	PMID:22722203|RGD:13702461
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IMP		Rat	PMID:22722203|RGD:13702461
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IDA		Rat	PMID:23911103|RGD:13702303
Cellular Component	GO:0098978	glutamatergic synapse	Gpc4	IMP		Rat	PMID:23911103|RGD:13702303
Cellular Component	GO:0005634	nucleus	GPC4	HDA		Human	PMID:21630459
Cellular Component	GO:0042734	presynaptic membrane	Gpc4	IDA		Rat	PMID:23911103|RGD:13702303
Cellular Component	GO:0042734	presynaptic membrane	Gpc4	IMP		Rat	PMID:23911103|RGD:13702303
Cellular Component	GO:0045202	synapse	Gpc4	EXP		Mouse	PMID:16452087
Cellular Component	GO:0045202	synapse	Gpc4	IDA		Mouse	PMID:16452087
Biological Process	GO:0051216	cartilage development	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:21294126
Biological Process	GO:0060536	cartilage morphogenesis	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:26459057
Biological Process	GO:0060536	cartilage morphogenesis	gpc4	IMP	ZFIN:ZDB-GENO-100419-4	Zfish	PMID:26459057
Biological Process	GO:0060536	cartilage morphogenesis	gpc4	IMP	ZFIN:ZDB-GENO-080710-2	Zfish	PMID:27908786
Biological Process	GO:0016477	cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-2,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IMP	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0016477	cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-011119-1	Zfish	PMID:30082271
Biological Process	GO:0042074	cell migration involved in gastrulation	gpc4	IGI	ZFIN:ZDB-GENE-990708-5	Zfish	PMID:17322405
Biological Process	GO:0060026	convergent extension	gpc4	IMP	ZFIN:ZDB-GENO-080416-1	Zfish	PMID:18195109
Biological Process	GO:0060026	convergent extension	gpc4	IMP	ZFIN:ZDB-MRPHLNO-150402-8	Zfish	PMID:19465602
Biological Process	GO:0060028	convergent extension involved in axis elongation	gpc4	IGI	ZFIN:ZDB-GENO-080512-6	Zfish	PMID:14660439
Biological Process	GO:0060028	convergent extension involved in axis elongation	gpc4	IMP	ZFIN:ZDB-MRPHLNO-150402-8	Zfish	PMID:19465602
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IMP	ZFIN:ZDB-MRPHLNO-150402-8	Zfish	PMID:19465602
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IGI	ZFIN:ZDB-MRPHLNO-130215-1	Zfish	PMID:25183869
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IGI	ZFIN:ZDB-GENE-020507-3,ZFIN:ZDB-GENO-070906-2	Zfish	PMID:17239849
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IGI	ZFIN:ZDB-GENO-070906-1,ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5	Zfish	PMID:18423448
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IGI	ZFIN:ZDB-GENO-100715-12	Zfish	PMID:11702784
Biological Process	GO:0060027	convergent extension involved in gastrulation	gpc4	IMP	ZFIN:ZDB-GENO-081103-3	Zfish	PMID:18423448
Biological Process	GO:0060030	dorsal convergence	gpc4	IMP	ZFIN:ZDB-GENO-980202-187	Zfish	PMID:9007234
Biological Process	GO:0001958	endochondral ossification	gpc4	IMP	ZFIN:ZDB-GENO-080710-2	Zfish	PMID:27908786
Biological Process	GO:0003379	establishment of cell polarity involved in gastrulation cell migration	gpc4	IMP	ZFIN:ZDB-GENO-980202-187	Zfish	PMID:11702784
Biological Process	GO:0030198	extracellular matrix organization	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:21506131
Biological Process	GO:0030198	extracellular matrix organization	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:24021482
Biological Process	GO:0001702	gastrulation with mouth forming second	gpc4	IMP	ZFIN:ZDB-GENO-980202-187	Zfish	PMID:15928205
Biological Process	GO:0097581	lamellipodium organization	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0097581	lamellipodium organization	gpc4	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0055001	muscle cell development	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:27640326
Biological Process	GO:0014812	muscle cell migration	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:17849437
Biological Process	GO:0014812	muscle cell migration	gpc4	IGI	ZFIN:ZDB-GENO-070906-2	Zfish	PMID:17849437
Biological Process	GO:0048884	neuromast development	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:31488837
Biological Process	GO:0030903	notochord development	gpc4	IMP	ZFIN:ZDB-GENO-980202-187	Zfish	PMID:9007234
Biological Process	GO:0001503	ossification	gpc4	IMP	ZFIN:ZDB-GENO-080710-2	Zfish	PMID:27908786
Biological Process	GO:0060037	pharyngeal system development	gpc4	IMP	ZFIN:ZDB-GENO-100419-4	Zfish	PMID:19777561
Biological Process	GO:0036342	post-anal tail morphogenesis	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:21610036
Biological Process	GO:0036342	post-anal tail morphogenesis	gpc4	IGI	ZFIN:ZDB-GENO-100601-3,ZFIN:ZDB-GENO-120430-1	Zfish	PMID:21610036
Biological Process	GO:0008104	protein localization	gpc4	IGI	ZFIN:ZDB-GENE-990708-5	Zfish	PMID:17322405
Biological Process	GO:0030166	proteoglycan biosynthetic process	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:21294126
Biological Process	GO:0030334	regulation of cell migration	gpc4	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0030334	regulation of cell migration	gpc4	IGI	ZFIN:ZDB-GENE-990708-5	Zfish	PMID:17322405
Biological Process	GO:1901201	regulation of extracellular matrix assembly	gpc4	IGI	ZFIN:ZDB-GENE-030901-1,ZFIN:ZDB-GENE-030901-2	Zfish	PMID:30082271
Biological Process	GO:1901201	regulation of extracellular matrix assembly	gpc4	IMP	ZFIN:ZDB-GENO-120430-1	Zfish	PMID:30082271
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Gpc4	IDA		Rat	PMID:22722203|RGD:13702461
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Gpc4	IMP		Rat	PMID:22722203|RGD:13702461
Biological Process	GO:1905606	regulation of presynapse assembly	Gpc4	IDA		Rat	PMID:23911103|RGD:13702303
Biological Process	GO:1905606	regulation of presynapse assembly	Gpc4	IMP		Rat	PMID:23911103|RGD:13702303
Biological Process	GO:0055002	striated muscle cell development	gpc4	IGI	ZFIN:ZDB-GENO-070906-2	Zfish	PMID:17849437
Biological Process	GO:0055002	striated muscle cell development	gpc4	IMP	ZFIN:ZDB-GENO-070906-1	Zfish	PMID:17849437
Biological Process	GO:0099560	synaptic membrane adhesion	Gpc4	IDA		Mouse	PMID:23911103
Biological Process	GO:0099560	synaptic membrane adhesion	Gpc4	IMP		Mouse	PMID:23911103
Biological Process	GO:0009826	unidimensional cell growth	gpc4	IMP	ZFIN:ZDB-GENO-980202-187	Zfish	PMID:15928205
Biological Process	GO:0016055	Wnt signaling pathway	GPC4	IMP		Human	PMID:29276006

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern