Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPER1
  • Mouse genes Gper1
  • Rat genes Gper1
  • Zfish genes gper1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gper1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	GPER1	IDA		Human	PMID:20551055
Molecular Function	GO:1903924	estradiol binding	Gper1	IMP		Rat	PMID:24262995|RGD:39939015
Molecular Function	GO:0038054	G protein-coupled estrogen receptor activity	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Molecular Function	GO:0038054	G protein-coupled estrogen receptor activity	gper1	IDA		Zfish	PMID:19228597
Molecular Function	GO:0030284	nuclear estrogen receptor activity	GPER1	IDA		Human	PMID:15539556
Molecular Function	GO:0030284	nuclear estrogen receptor activity	GPER1	IDA		Human	PMID:15705806
Molecular Function	GO:0030284	nuclear estrogen receptor activity	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Molecular Function	GO:0005515	protein binding	GPER1	IPI	UniProtKB:P00533	Human	PMID:20551055
Molecular Function	GO:0005515	protein binding	GPER1	IPI	UniProtKB:P05787	Human	PMID:21149639
Molecular Function	GO:0005515	protein binding	GPER1	IPI	UniProtKB:P08729	Human	PMID:21149639
Molecular Function	GO:0005515	protein binding	GPER1	IPI	UniProtKB:O60896	Human	PMID:23674134
Molecular Function	GO:0005496	steroid binding	GPER1	IDA		Human	PMID:15539556
Molecular Function	GO:0005496	steroid binding	GPER1	IDA		Human	PMID:15705806
Molecular Function	GO:0005496	steroid binding	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Molecular Function	GO:1990239	steroid hormone binding	GPER1	IDA		Human	PMID:19931550
Cellular Component	GO:0030424	axon	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0043679	axon terminus	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0005737	cytoplasm	Gper1	IDA		Mouse	MGI:MGI:5508734|PMID:21149639
Cellular Component	GO:0005737	cytoplasm	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Cellular Component	GO:0005737	cytoplasm	Gper1	IDA		Rat	PMID:20445128|RGD:4892084
Cellular Component	GO:0005737	cytoplasm	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005829	cytosol	GPER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0043198	dendritic shaft	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0043198	dendritic shaft	Gper1	IDA		Rat	PMID:23822769|RGD:8554508
Cellular Component	GO:0044327	dendritic spine head	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0032591	dendritic spine membrane	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0032591	dendritic spine membrane	Gper1	IDA		Rat	PMID:23822769|RGD:8554508
Cellular Component	GO:0005769	early endosome	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005783	endoplasmic reticulum	GPER1	IDA		Human	PMID:15705806
Cellular Component	GO:0005783	endoplasmic reticulum	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Gper1	IDA		Rat	PMID:24262995|RGD:39939015
Cellular Component	GO:0005794	Golgi apparatus	GPER1	IDA		Human	PMID:15705806
Cellular Component	GO:0005794	Golgi apparatus	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Gper1	EXP		Mouse	PMID:29421611
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Gper1	IDA		Mouse	PMID:29421611
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GPER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045095	keratin filament	GPER1	IDA		Human	PMID:21149639
Cellular Component	GO:0031966	mitochondrial membrane	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0043025	neuronal cell body	Gper1	IDA		Rat	PMID:19095043|RGD:39939084
Cellular Component	GO:0005635	nuclear envelope	GPER1	IDA		Human	PMID:15705806
Cellular Component	GO:0005730	nucleolus	GPER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GPER1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GPER1	IDA		Human	PMID:20551055
Cellular Component	GO:0005634	nucleus	GPER1	IDA		Human	PMID:23285008
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:15539556
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:19931550
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:21149639
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:21427217
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005886	plasma membrane	GPER1	IDA		Human	PMID:23674134
Cellular Component	GO:0005886	plasma membrane	Gper1	IDA		Mouse	MGI:MGI:5514109|PMID:23674134
Cellular Component	GO:0005886	plasma membrane	Gper1	IDA		Mouse	MGI:MGI:5508734|PMID:21149639
Cellular Component	GO:0005886	plasma membrane	Gper1	IDA		Rat	PMID:18489713|RGD:4892089
Cellular Component	GO:0005886	plasma membrane	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0005886	plasma membrane	gper1	IDA		Zfish	PMID:19228597
Cellular Component	GO:0014069	postsynaptic density	Gper1	IDA		Rat	PMID:22919059|RGD:8553395
Cellular Component	GO:0014069	postsynaptic density	Gper1	IDA		Rat	PMID:23822769|RGD:8554508
Cellular Component	GO:0048786	presynaptic active zone	Gper1	IDA		Rat	PMID:23822769|RGD:8554508
Cellular Component	GO:0042734	presynaptic membrane	Gper1	IDA		Rat	PMID:23822769|RGD:8554508
Cellular Component	GO:0055037	recycling endosome	GPER1	IDA		Human	PMID:21540189
Cellular Component	GO:0005802	trans-Golgi network	GPER1	IDA		Human	PMID:21540189
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GPER1	IDA		Human	PMID:15539556
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gper1	IDA		Mouse	MGI:MGI:5508734|PMID:21149639
Biological Process	GO:0030263	apoptotic chromosome condensation	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0007420	brain development	gper1	IDA		Zfish	PMID:23583372|ZFIN:ZDB-PUB-130422-13
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:15539556
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:19931550
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:20551055
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:21149639
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:21427217
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:21540189
Biological Process	GO:0071392	cellular response to estradiol stimulus	GPER1	IDA		Human	PMID:23285008
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Mouse	MGI:MGI:5508734|PMID:21149639
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Biological Process	GO:0071392	cellular response to estradiol stimulus	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0071392	cellular response to estradiol stimulus	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Biological Process	GO:0071333	cellular response to glucose stimulus	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0071389	cellular response to mineralocorticoid stimulus	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	GPER1	IDA		Human	PMID:21427217
Biological Process	GO:0071356	cellular response to tumor necrosis factor	GPER1	IDA		Human	PMID:23285008
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Biological Process	GO:0060047	heart contraction	gper1	IMP	ZFIN:ZDB-GENO-180801-2	Zfish	PMID:29065151
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	Gper1	IMP		Rat	PMID:20445128|RGD:4892084
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	Gper1	IDA		Rat	PMID:20445128|RGD:4892084
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Gper1	EXP		Mouse	PMID:29421611
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Gper1	IDA		Mouse	PMID:29421611
Biological Process	GO:0010948	negative regulation of cell cycle process	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0008285	negative regulation of cell population proliferation	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:0010629	negative regulation of gene expression	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0010629	negative regulation of gene expression	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0050728	negative regulation of inflammatory response	GPER1	IDA		Human	PMID:23285008
Biological Process	GO:0002695	negative regulation of leukocyte activation	GPER1	IDA		Human	PMID:23285008
Biological Process	GO:0051055	negative regulation of lipid biosynthetic process	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	gper1	IDA		Zfish	PMID:18420744|ZFIN:ZDB-PUB-080422-10
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	gper1	IDA		Zfish	PMID:23583372|ZFIN:ZDB-PUB-130422-13
Biological Process	GO:1900194	negative regulation of oocyte maturation	gper1	IDA		Zfish	PMID:18420744|ZFIN:ZDB-PUB-080422-10
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:1900121	negative regulation of receptor binding	Gper1	IMP		Rat	PMID:24262995|RGD:39939015
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0043065	positive regulation of apoptotic process	Gper1	IMP		Rat	PMID:22975889|RGD:8552988
Biological Process	GO:0043065	positive regulation of apoptotic process	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:2000724	positive regulation of cardiac vascular smooth muscle cell differentiation	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0030335	positive regulation of cell migration	GPER1	IMP		Human	PMID:20551055
Biological Process	GO:0008284	positive regulation of cell population proliferation	GPER1	IMP		Human	PMID:20551055
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0040019	positive regulation of embryonic development	gper1	IMP		Zfish	PMID:23583372|ZFIN:ZDB-PUB-130422-13
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Gper1	IMP		Rat	PMID:20445128|RGD:4892084
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GPER1	IDA		Human	PMID:20551055
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GPER1	IDA		Human	PMID:21427217
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Rat	PMID:19717735|RGD:4892081
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IMP		Rat	PMID:19717735|RGD:4892081
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Rat	PMID:20445128|RGD:4892084
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GPER1	IDA		Human	PMID:15539556
Biological Process	GO:0010628	positive regulation of gene expression	GPER1	IMP		Human	PMID:23840305
Biological Process	GO:0010628	positive regulation of gene expression	Gper1	IMP		Rat	PMID:23641788|RGD:39938862
Biological Process	GO:0010628	positive regulation of gene expression	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0032024	positive regulation of insulin secretion	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0043410	positive regulation of MAPK cascade	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	gper1	IDA		Zfish	PMID:23583372|ZFIN:ZDB-PUB-130422-13
Biological Process	GO:0050769	positive regulation of neurogenesis	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Gper1	IDA		Rat	PMID:19717735|RGD:4892081
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Gper1	IMP		Rat	PMID:24262995|RGD:39939015
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Gper1	IMP		Rat	PMID:19717735|RGD:4892081
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	GPER1	IDA		Human	PMID:23674134
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GPER1	IDA		Human	PMID:20551055
Biological Process	GO:0001934	positive regulation of protein phosphorylation	GPER1	IDA		Human	PMID:21427217
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gper1	IDA		Mouse	MGI:MGI:5141337|PMID:21673097
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Gper1	IMP		Rat	PMID:20445128|RGD:4892084
Biological Process	GO:0001934	positive regulation of protein phosphorylation	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	Gper1	IDA		Rat	PMID:23907461|RGD:8553942
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GPER1	IDA		Human	PMID:15705806
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GPER1	IDA		Human	PMID:20551055
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gper1	IDA		Mouse	MGI:MGI:5512928|PMID:23545157
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	GPER1	IDA		Human	PMID:21427217
Biological Process	GO:1905152	positive regulation of voltage-gated sodium channel activity	Gper1	IMP		Rat	PMID:24097558|RGD:39939085
Biological Process	GO:0051726	regulation of cell cycle	Gper1	IDA		Mouse	MGI:MGI:5516154|PMID:23871778
Biological Process	GO:2000354	regulation of ovarian follicle development	gper1	IMP	ZFIN:ZDB-GENO-220621-1	Zfish	PMID:33790865
Biological Process	GO:1903186	regulation of vitellogenesis	gper1	IMP	ZFIN:ZDB-GENO-220621-1	Zfish	PMID:33790865
Biological Process	GO:0007210	serotonin receptor signaling pathway	Gper1	IMP		Rat	PMID:19095043|RGD:39939084
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	GPER1	IDA		Human	PMID:19931550
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	gper1	IDA		Zfish	PMID:19228597|ZFIN:ZDB-PUB-090302-4
Biological Process	GO:0042311	vasodilation	Gper1	IDA		Rat	PMID:23283935|RGD:8553898
Biological Process	GO:0042311	vasodilation	Gper1	IMP		Rat	PMID:30354811|RGD:39939000

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern