Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPR137B
  • Mouse genes Gpr137b
  • Rat genes Gpr137b
  • Zfish genes gpr137ba,gpr137bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpr137b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GPR137B	IPI	UniProtKB:Q13049	Human	PMID:32296183
Cellular Component	GO:0005765	lysosomal membrane	GPR137B	IDA		Human	PMID:31036939
Cellular Component	GO:0005765	lysosomal membrane	Gpr137b	IMP		Mouse	MGI:MGI:6362357|PMID:31173907
Biological Process	GO:0046849	bone remodeling	gpr137ba	IMP	ZFIN:ZDB-GENO-200610-3	Zfish	PMID:31173907
Biological Process	GO:0045779	negative regulation of bone resorption	Gpr137b	IMP		Mouse	MGI:MGI:6362357|PMID:31173907
Biological Process	GO:0045779	negative regulation of bone resorption	gpr137ba	IMP		Zfish	PMID:31173907|ZFIN:ZDB-PUB-190608-10
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Gpr137b	IMP		Mouse	MGI:MGI:6362357|PMID:31173907
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	gpr137ba	IMP		Zfish	PMID:31173907|ZFIN:ZDB-PUB-190608-10
Biological Process	GO:0150032	positive regulation of protein localization to lysosome	GPR137B	IMP		Human	PMID:31036939
Biological Process	GO:1904263	positive regulation of TORC1 signaling	GPR137B	IMP		Human	PMID:31036939
Biological Process	GO:0010506	regulation of autophagy	GPR137B	IMP		Human	PMID:31036939
Biological Process	GO:0010506	regulation of autophagy	gpr137ba	IMP		Zfish	PMID:31036939|ZFIN:ZDB-PUB-190501-6
Biological Process	GO:0043087	regulation of GTPase activity	GPR137B	IMP		Human	PMID:31036939
Biological Process	GO:0043087	regulation of GTPase activity	gpr137ba	IMP		Zfish	PMID:31036939|ZFIN:ZDB-PUB-190501-6
Biological Process	GO:0062196	regulation of lysosome size	gpr137ba	IMP	ZFIN:ZDB-FISH-210614-1	Zfish	PMID:31036939
Biological Process	GO:0043030	regulation of macrophage activation	Gpr137b	IMP		Mouse	MGI:MGI:6378134|PMID:30595385

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern