Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GPR4
  • Mouse genes Gpr4
  • Rat genes Gpr4
  • Zfish genes gpr4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	GPR4	IMP		Human	PMID:20211729
Molecular Function	GO:0004930	G protein-coupled receptor activity	Gpr4	IDA		Mouse	PMID:17145776
Molecular Function	GO:0004930	G protein-coupled receptor activity	Gpr4	IMP	MGI:MGI:3700206	Mouse	PMID:17145776
Molecular Function	GO:0004930	G protein-coupled receptor activity	gpr4	IDA		Zfish	PMID:28270026
Cellular Component	GO:0005886	plasma membrane	GPR4	IDA		Human	PMID:20211729
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GPR4	IMP		Human	PMID:12955148
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GPR4	IDA		Human	PMID:17462861
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GPR4	IMP		Human	PMID:20211729
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GPR4	IDA		Human	PMID:22110680
Biological Process	GO:0060055	angiogenesis involved in wound healing	Gpr4	IDA		Mouse	PMID:17145776
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gpr4	IDA		Mouse	PMID:17145776
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Gpr4	IMP	MGI:MGI:3700206	Mouse	PMID:17145776
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	gpr4	IDA		Zfish	PMID:28270026
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	gpr4	IDA		Zfish	PMID:25576873
Biological Process	GO:0072144	glomerular mesangial cell development	Gpr4	IMP	MGI:MGI:3700206	Mouse	PMID:17145776
Biological Process	GO:0016525	negative regulation of angiogenesis	Gpr4	IMP	MGI:MGI:3700206	Mouse	PMID:17145776
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GPR4	IMP		Human	PMID:20211729
Biological Process	GO:0050729	positive regulation of inflammatory response	Gpr4	IMP		Mouse	MGI:MGI:6414996|PMID:32058960
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	GPR4	IDA		Human	PMID:17462861
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	GPR4	IMP		Human	PMID:20211729
Biological Process	GO:0030155	regulation of cell adhesion	GPR4	IDA		Human	PMID:22110680
Biological Process	GO:0043114	regulation of vascular permeability	Gpr4	IMP		Mouse	MGI:MGI:6414996|PMID:32058960
Biological Process	GO:0010447	response to acidic pH	GPR4	IMP		Human	PMID:12955148
Biological Process	GO:0010447	response to acidic pH	GPR4	IDA		Human	PMID:17462861
Biological Process	GO:0010447	response to acidic pH	GPR4	IDA		Human	PMID:22110680
Biological Process	GO:0010447	response to acidic pH	Gpr4	IMP	MGI:MGI:3700206	Mouse	PMID:17145776
Biological Process	GO:0010447	response to acidic pH	Gpr4	IDA		Mouse	PMID:17145776
Biological Process	GO:0010447	response to acidic pH	gpr4	IDA		Zfish	PMID:28270026

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern