Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gpx1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GPX1
- Mouse genes Gpx1
- Rat genes Gpx1
- Zfish genes gpx1a,gpx1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gpx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004602	glutathione peroxidase activity	GPX1	IDA		Human	PMID:12829378
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP		Mouse	MGI:MGI:893248\|PMID:9195979
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12117267
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IDA		Mouse	PMID:12646716
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11893559
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:9386101
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:15182862
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11518697
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:9788901
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11311045
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915653
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10490281
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IDA		Mouse	PMID:12521604
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12751789
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11545230
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915565
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:15827346
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IDA		Rat	PMID:16140890\|RGD:1624364
Molecular Function	GO:0004602	glutathione peroxidase activity	Gpx1	IDA		Rat	PMID:1640255\|RGD:728717
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	GPX1	IDA		Human	PMID:11115402
Molecular Function	GO:0005515	protein binding	Gpx1	IPI	UniProtKB:Q9CQ86	Mouse	MGI:MGI:3713966\|PMID:17503775
Molecular Function	GO:0017124	SH3 domain binding	GPX1	IPI	UniProtKB:P00519	Human	PMID:12893824
Molecular Function	GO:0017124	SH3 domain binding	GPX1	IPI	UniProtKB:P42684	Human	PMID:12893824
Cellular Component	GO:0005737	cytoplasm	GPX1	IDA		Human	PMID:10833429
Cellular Component	GO:0005829	cytosol	GPX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Gpx1	IDA		Rat	PMID:1640255\|RGD:728717
Cellular Component	GO:0097413	Lewy body	GPX1	IDA		Human	PMID:18853169
Cellular Component	GO:0005739	mitochondrion	GPX1	IDA		Human	PMID:10833429
Cellular Component	GO:0005739	mitochondrion	Gpx1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Gpx1	IDA		Mouse	PMID:9126277
Cellular Component	GO:0005739	mitochondrion	Gpx1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Gpx1	IMP	MGI:MGI:3589261	Mouse	PMID:10754271
Cellular Component	GO:0005739	mitochondrion	Gpx1	IDA		Rat	PMID:19914224\|RGD:9068475
Cellular Component	GO:0005634	nucleus	Gpx1	IDA		Rat	PMID:12516874\|RGD:1600690
Biological Process	GO:0007568	aging	Gpx1	IEP		Rat	PMID:17021340\|RGD:2306622
Biological Process	GO:0060055	angiogenesis involved in wound healing	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0006915	apoptotic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0006915	apoptotic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16934683
Biological Process	GO:0019369	arachidonic acid metabolic process	GPX1	IDA		Human	PMID:11115402
Biological Process	GO:0019369	arachidonic acid metabolic process	Gpx1	IMP		Mouse	MGI:MGI:893248\|PMID:9195979
Biological Process	GO:0051702	biological process involved in interaction with symbiont	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:12751789
Biological Process	GO:0051702	biological process involved in interaction with symbiont	Gpx1	IGI	MGI:MGI:106609	Mouse	PMID:12751789
Biological Process	GO:0043534	blood vessel endothelial cell migration	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0045454	cell redox homeostasis	GPX1	IDA		Human	PMID:12829378
Biological Process	GO:0098869	cellular oxidant detoxification	Gpx1	IMP	MGI:MGI:2158814	Mouse	MGI:MGI:3608474\|PMID:12751789
Biological Process	GO:0071333	cellular response to glucose stimulus	Gpx1	IDA		Rat	PMID:19944066\|RGD:11352826
Biological Process	GO:0001885	endothelial cell development	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0040029	epigenetic regulation of gene expression	GPX1	IDA		Human	PMID:16132718
Biological Process	GO:0045444	fat cell differentiation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0048144	fibroblast proliferation	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:14732290
Biological Process	GO:0006749	glutathione metabolic process	GPX1	IDA		Human	PMID:12829378
Biological Process	GO:0006749	glutathione metabolic process	Gpx1	IDA		Rat	PMID:16140890\|RGD:1624364
Biological Process	GO:0060047	heart contraction	GPX1	IMP		Human	PMID:14573732
Biological Process	GO:0060047	heart contraction	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12196344
Biological Process	GO:0042744	hydrogen peroxide catabolic process	GPX1	IDA		Human	PMID:15203190
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:9788901
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:15182862
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:3589261	Mouse	PMID:10754271
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915565
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:15827346
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11545230
Biological Process	GO:0042744	hydrogen peroxide catabolic process	Gpx1	IDA		Rat	PMID:16140890\|RGD:1624364
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11562367
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:15663476
Biological Process	GO:0006629	lipid metabolic process	Gpx1	IMP	MGI:MGI:3589261	Mouse	PMID:10754271
Biological Process	GO:0019372	lipoxygenase pathway	GPX1	IDA		Human	PMID:11115402
Biological Process	GO:0045445	myoblast differentiation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0051450	myoblast proliferation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12368211
Biological Process	GO:0051450	myoblast proliferation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0014902	myotube differentiation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12368211
Biological Process	GO:0014902	myotube differentiation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GPX1	IMP		Human	PMID:12221075
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GPX1	IMP		Human	PMID:12221075
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:12751789
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Gpx1	IGI	MGI:MGI:106609	Mouse	PMID:12751789
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GPX1	IMP		Human	PMID:12221075
Biological Process	GO:0051402	neuron apoptotic process	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:11579147
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:15663476
Biological Process	GO:0018158	protein oxidation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10428770
Biological Process	GO:0033599	regulation of mammary gland epithelial cell proliferation	GPX1	IMP		Human	PMID:16945136
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	GPX1	IDA		Human	PMID:12751788
Biological Process	GO:0032355	response to estradiol	Gpx1	IEP		Rat	PMID:17211248\|RGD:2306621
Biological Process	GO:0051593	response to folic acid	Gpx1	IEP		Rat	PMID:16251605\|RGD:2306623
Biological Process	GO:0010332	response to gamma radiation	Gpx1	IGI	MGI:MGI:98352	Mouse	PMID:15182862
Biological Process	GO:0010332	response to gamma radiation	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:15182862
Biological Process	GO:0009749	response to glucose	Gpx1	IEP		Rat	PMID:15039483\|RGD:2306161
Biological Process	GO:0009725	response to hormone	Gpx1	IEP		Rat	PMID:17561443\|RGD:2306620
Biological Process	GO:0042542	response to hydrogen peroxide	GPX1	IMP		Human	PMID:12829378
Biological Process	GO:0042542	response to hydrogen peroxide	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:14732290
Biological Process	GO:0042542	response to hydrogen peroxide	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0033194	response to hydroperoxide	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:16723478
Biological Process	GO:0035094	response to nicotine	Gpx1	IEP		Rat	PMID:18343235\|RGD:2306617
Biological Process	GO:0014070	response to organic cyclic compound	Gpx1	IEP		Rat	PMID:18255150\|RGD:2306618
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12196344
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IGI	MGI:MGI:98352	Mouse	PMID:15182862
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11893559
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10428770
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915565
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0006979	response to oxidative stress	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10627575
Biological Process	GO:0000302	response to reactive oxygen species	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11562367
Biological Process	GO:0000302	response to reactive oxygen species	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915565
Biological Process	GO:0000302	response to reactive oxygen species	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0000302	response to reactive oxygen species	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:17145560
Biological Process	GO:0000302	response to reactive oxygen species	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16373599
Biological Process	GO:0010269	response to selenium ion	GPX1	IMP		Human	PMID:12810669
Biological Process	GO:0010269	response to selenium ion	Gpx1	IEP		Rat	PMID:19234057\|RGD:2306614
Biological Process	GO:0010269	response to selenium ion	Gpx1	IEP		Rat	PMID:23271678\|RGD:152998882
Biological Process	GO:0010269	response to selenium ion	Gpx1	IEP		Rat	PMID:24176350\|RGD:152023635
Biological Process	GO:0009609	response to symbiotic bacterium	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:12751789
Biological Process	GO:0009609	response to symbiotic bacterium	Gpx1	IGI	MGI:MGI:106609	Mouse	PMID:12751789
Biological Process	GO:0009636	response to toxic substance	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10627575
Biological Process	GO:0033197	response to vitamin E	Gpx1	IEP		Rat	PMID:16038882\|RGD:152998891
Biological Process	GO:0009611	response to wounding	Gpx1	IMP	MGI:MGI:2388705	Mouse	PMID:11579147
Biological Process	GO:0009410	response to xenobiotic stimulus	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:10915565
Biological Process	GO:0007605	sensory perception of sound	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11545230
Biological Process	GO:0048741	skeletal muscle fiber development	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:16962942
Biological Process	GO:0001659	temperature homeostasis	Gpx1	IGI	MGI:MGI:104887	Mouse	PMID:11518697
Biological Process	GO:0001659	temperature homeostasis	Gpx1	IGI	MGI:MGI:106609	Mouse	PMID:11518697
Biological Process	GO:0006641	triglyceride metabolic process	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12117267
Biological Process	GO:0009650	UV protection	GPX1	IMP		Human	PMID:17097614
Biological Process	GO:0042311	vasodilation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:12196344
Biological Process	GO:0042311	vasodilation	Gpx1	IMP	MGI:MGI:2158814	Mouse	PMID:11893559

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.