Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRHL1
  • Mouse genes Grhl1
  • Rat genes Grhl1
  • Zfish genes grhl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grhl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	GRHL1	IDA		Human	PMID:21081122
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GRHL1	IDA		Human	PMID:12175488
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GRHL1	IMP		Human	PMID:29309642
Molecular Function	GO:0005515	protein binding	GRHL1	IPI	UniProtKB:Q9NZI5	Human	PMID:29309642
Molecular Function	GO:0042803	protein homodimerization activity	GRHL1	IPI	UniProtKB:Q9NZI5	Human	PMID:29309642
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	GRHL1	IDA		Human	PMID:12175488
Molecular Function	GO:0043565	sequence-specific DNA binding	GRHL1	IDA		Human	PMID:18288204
Molecular Function	GO:0043565	sequence-specific DNA binding	Grhl1	IDA		Mouse	MGI:MGI:4881608|PMID:21081122
Molecular Function	GO:0043565	sequence-specific DNA binding	Grhl1	IDA		Mouse	MGI:MGI:3778256|PMID:18288204
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GRHL1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	GRHL1	IDA		Human	PMID:18288204
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Grhl1	IDA		Mouse	MGI:MGI:3778256|PMID:18288204
Cellular Component	GO:0005737	cytoplasm	grhl1	IDA		Zfish	PMID:19757382
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GRHL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GRHL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GRHL1	IDA		Human	PMID:18288204
Cellular Component	GO:0005634	nucleus	GRHL1	IDA		Human	PMID:21081122
Cellular Component	GO:0005634	nucleus	Grhl1	IDA		Mouse	MGI:MGI:3778256|PMID:18288204
Biological Process	GO:0002934	desmosome organization	Grhl1	IMP	MGI:MGI:3778923	Mouse	PMID:24586629
Biological Process	GO:0002934	desmosome organization	grhl1	IMP	ZFIN:ZDB-MRPHLNO-101108-7	Zfish	PMID:25896282
Biological Process	GO:0090504	epiboly	grhl1	IGI	ZFIN:ZDB-MRPHLNO-101108-8,ZFIN:ZDB-MRPHLNO-130215-2	Zfish	PMID:28886269
Biological Process	GO:0008544	epidermis development	Grhl1	IDA		Mouse	MGI:MGI:3778256|PMID:18288204
Biological Process	GO:0008544	epidermis development	Grhl1	IMP		Mouse	MGI:MGI:4881608|PMID:21081122
Biological Process	GO:0008544	epidermis development	grhl1	IMP	ZFIN:ZDB-MRPHLNO-101108-7	Zfish	PMID:19757382
Biological Process	GO:0008544	epidermis development	grhl1	IGI	ZFIN:ZDB-MRPHLNO-101108-8,ZFIN:ZDB-MRPHLNO-130215-2	Zfish	PMID:22931925
Biological Process	GO:0061436	establishment of skin barrier	Grhl1	IMP	MGI:MGI:3778923	Mouse	PMID:24586629
Biological Process	GO:0048839	inner ear development	grhl1	IMP	ZFIN:ZDB-MRPHLNO-101108-7	Zfish	PMID:25896282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GRHL1	IDA		Human	PMID:12175488
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GRHL1	IMP		Human	PMID:29309642
Biological Process	GO:0045616	regulation of keratinocyte differentiation	Grhl1	IMP	MGI:MGI:3778923	Mouse	PMID:24586629

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern