Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRHL3
  • Mouse genes Grhl3
  • Rat genes Grhl3
  • Zfish genes grhl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grhl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	grhl3	IDA		Zfish	PMID:24915580
Molecular Function	GO:0031490	chromatin DNA binding	GRHL3	IDA		Human	PMID:21081122
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GRHL3	IDA		Human	PMID:23685552
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Grhl3	IDA		Mouse	PMID:20643356
Molecular Function	GO:0005515	protein binding	GRHL3	IPI	UniProtKB:O14744	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	GRHL3	IPI	UniProtKB:Q96LA8	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	Grhl3	IPI	UniProtKB:P61969	Mouse	MGI:MGI:3689640|PMID:16949565
Molecular Function	GO:0005515	protein binding	Grhl3	IPI	PR:P61969	Mouse	PMID:12666198
Molecular Function	GO:0005515	protein binding	Grhl3	IPI	PR:Q5FWH3	Mouse	PMID:12666198
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Grhl3	IDA		Mouse	PMID:15831758
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Grhl3	IDA		Mouse	PMID:12666198
Molecular Function	GO:0043565	sequence-specific DNA binding	Grhl3	IDA		Mouse	MGI:MGI:4881608|PMID:21081122
Molecular Function	GO:0043565	sequence-specific DNA binding	Grhl3	IDA		Mouse	PMID:12666198
Molecular Function	GO:0043565	sequence-specific DNA binding	grhl3	IDA		Zfish	PMID:24915580
Cellular Component	GO:0005654	nucleoplasm	GRHL3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GRHL3	IDA		Human	PMID:21081122
Cellular Component	GO:0005634	nucleus	Grhl3	IDA		Mouse	PMID:12666198
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	grhl3	IDA		Zfish	PMID:18618001
Biological Process	GO:0007417	central nervous system development	Grhl3	IMP	MGI:MGI:1856837	Mouse	PMID:11787818
Biological Process	GO:0090103	cochlea morphogenesis	Grhl3	IGI	MGI:MGI:2135272	Mouse	PMID:20643356
Biological Process	GO:0007398	ectoderm development	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:14608380
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	grhl3	IGI	ZFIN:ZDB-GENE-000920-1	Zfish	PMID:24915580
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	grhl3	IMP	ZFIN:ZDB-MRPHLNO-141230-25	Zfish	PMID:24915580
Biological Process	GO:0090504	epiboly	grhl3	IGI	ZFIN:ZDB-MRPHLNO-101108-8,ZFIN:ZDB-MRPHLNO-130215-2	Zfish	PMID:28886269
Biological Process	GO:0008544	epidermis development	Grhl3	IMP		Mouse	MGI:MGI:4881608|PMID:21081122
Biological Process	GO:0008544	epidermis development	Grhl3	IMP		Mouse	MGI:MGI:3689640|PMID:16949565
Biological Process	GO:0008544	epidermis development	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:15831758
Biological Process	GO:0008544	epidermis development	grhl3	IGI	ZFIN:ZDB-MRPHLNO-141230-25,ZFIN:ZDB-MRPHLNO-180514-1	Zfish	PMID:29242584
Biological Process	GO:0008544	epidermis development	grhl3	IGI	ZFIN:ZDB-MRPHLNO-101108-8,ZFIN:ZDB-MRPHLNO-130215-2	Zfish	PMID:22931925
Biological Process	GO:0001736	establishment of planar polarity	Grhl3	IGI	MGI:MGI:2135272	Mouse	PMID:20643356
Biological Process	GO:0061436	establishment of skin barrier	Grhl3	IMP		Mouse	MGI:MGI:5617425|PMID:25347468
Biological Process	GO:0061029	eyelid development in camera-type eye	Grhl3	IMP	MGI:MGI:1856837	Mouse	PMID:21262862
Biological Process	GO:0060325	face morphogenesis	grhl3	IMP	ZFIN:ZDB-MRPHLNO-141230-25	Zfish	PMID:24915580
Biological Process	GO:0010467	gene expression	Grhl3	IMP		Mouse	PMID:27208706
Biological Process	GO:0030917	midbrain-hindbrain boundary development	grhl3	IGI	ZFIN:ZDB-MRPHLNO-120207-2,ZFIN:ZDB-MRPHLNO-141230-25	Zfish	PMID:29242584
Biological Process	GO:0030917	midbrain-hindbrain boundary development	grhl3	IMP	ZFIN:ZDB-MRPHLNO-141230-25	Zfish	PMID:29242584
Biological Process	GO:0001843	neural tube closure	Grhl3	IMP		Mouse	MGI:MGI:3689640|PMID:16949565
Biological Process	GO:0001843	neural tube closure	Grhl3	IMP		Mouse	MGI:MGI:4835348|PMID:20654612
Biological Process	GO:0001843	neural tube closure	grhl3	IGI	ZFIN:ZDB-MRPHLNO-141230-25,ZFIN:ZDB-MRPHLNO-180514-1	Zfish	PMID:29242584
Biological Process	GO:0007389	pattern specification process	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:14608380
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Grhl3	IGI	MGI:MGI:2135272	Mouse	PMID:20643356
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Grhl3	IDA		Mouse	PMID:12666198
Biological Process	GO:0010628	positive regulation of gene expression	Grhl3	IMP	MGI:MGI:3690001	Mouse	PMID:19494835
Biological Process	GO:0043547	positive regulation of GTPase activity	Grhl3	IGI	MGI:MGI:1925912	Mouse	PMID:20643356
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	GRHL3	IDA		Human	PMID:23685552
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:20643356
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	GRHL3	IGI	UniProtKB:Q8IW93	Human	PMID:20643356
Biological Process	GO:0006366	transcription by RNA polymerase II	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Grhl3	IGI	MGI:MGI:2145950	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Grhl3	IGI	MGI:MGI:1100883	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Grhl3	IMP	MGI:MGI:2684328	Mouse	PMID:15831758
Biological Process	GO:0042060	wound healing	Grhl3	IGI	MGI:MGI:2135272	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Grhl3	IGI	MGI:MGI:1918711	Mouse	PMID:20643356

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern