Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRID2
  • Mouse genes Grid2
  • Rat genes Grid2
  • Zfish genes grid2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grid2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Grid2	IPI	UniProtKB:Q63226	Rat	PMID:17715062|RGD:13432254
Molecular Function	GO:0042802	identical protein binding	Grid2	IPI	UniProtKB:Q63226	Rat	PMID:19617541|RGD:13432236
Molecular Function	GO:0030165	PDZ domain binding	Grid2	IPI	UniProtKB:Q80Z38	Mouse	MGI:MGI:3852309|PMID:15207857
Molecular Function	GO:0030165	PDZ domain binding	Grid2	IPI	UniProtKB:O88382	Rat	PMID:12589829|RGD:632941
Molecular Function	GO:0005515	protein binding	GRID2	IPI	UniProtKB:P23435	Human	PMID:27418511
Molecular Function	GO:0005515	protein binding	Grid2	IPI	UniProtKB:D3YZU1|UniProtKB:Q4ACU6	Mouse	MGI:MGI:3852309|PMID:15207857
Molecular Function	GO:0005515	protein binding	Grid2	IPI	UniProtKB:Q9R171	Mouse	MGI:MGI:4839424|PMID:20537373
Molecular Function	GO:0005515	protein binding	Grid2	IPI	UniProtKB:Q9R171	Mouse	MGI:MGI:6271505|PMID:29782851
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:Q9Z2Y3	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:P11881	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:Q8BH60	Mouse	PMID:12372286
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:Q0QWG9	Mouse	PMID:11826110
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:Q0QWG9-3	Mouse	PMID:16168524
Molecular Function	GO:0005515	protein binding	Grid2	IPI	UniProtKB:Q9ET11	Mouse	PMID:11826110
Molecular Function	GO:0005515	protein binding	Grid2	IPI	PR:Q0QWG9-2	Mouse	PMID:16168524
Molecular Function	GO:0097110	scaffold protein binding	Grid2	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:3852309|PMID:15207857
Cellular Component	GO:0043197	dendritic spine	Grid2	IDA		Mouse	MGI:MGI:3852309|PMID:15207857
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IDA		Mouse	PMID:20395510
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IMP		Mouse	PMID:20395510
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IDA		Rat	PMID:20395510|RGD:13702347
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IMP		Rat	PMID:20395510|RGD:13702347
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IDA		Rat	PMID:21410790|RGD:13702257
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IMP		Rat	PMID:21410790|RGD:13702257
Cellular Component	GO:0098978	glutamatergic synapse	Grid2	IDA		Rat	PMID:8987804|RGD:2303500
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	Grid2	IDA		Mouse	MGI:MGI:3852309|PMID:15207857
Cellular Component	GO:0016020	membrane	Grid2	IDA		Mouse	PMID:15579147
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grid2	IDA		Mouse	PMID:20395510
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grid2	IMP		Mouse	PMID:20395510
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse	Grid2	IDA		Rat	PMID:8987804|RGD:2303500
Cellular Component	GO:0005886	plasma membrane	Grid2	IDA		Mouse	MGI:MGI:3852309|PMID:15207857
Cellular Component	GO:0014069	postsynaptic density	Grid2	IDA		Rat	PMID:16198122|RGD:2303501
Cellular Component	GO:0098839	postsynaptic density membrane	Grid2	IDA		Mouse	PMID:20395510
Cellular Component	GO:0098839	postsynaptic density membrane	Grid2	IMP		Mouse	PMID:20395510
Cellular Component	GO:0098839	postsynaptic density membrane	Grid2	IDA		Rat	PMID:8987804|RGD:2303500
Cellular Component	GO:0045211	postsynaptic membrane	Grid2	IDA		Mouse	MGI:MGI:3852309|PMID:15207857
Cellular Component	GO:0045211	postsynaptic membrane	Grid2	IDA		Rat	PMID:8987804|RGD:2303500
Cellular Component	GO:0036477	somatodendritic compartment	Grid2	IDA		Mouse	MGI:MGI:3794899|PMID:18341993
Cellular Component	GO:0045202	synapse	Grid2	IDA		Mouse	PMID:12372286
Cellular Component	GO:0045202	synapse	Grid2	IDA		Mouse	PMID:18509461
Biological Process	GO:0021707	cerebellar granule cell differentiation	Grid2	IGI	UniProtKB:Q9R171	Mouse	MGI:MGI:4839424|PMID:20537373
Biological Process	GO:0060079	excitatory postsynaptic potential	Grid2	IMP	MGI:MGI:2178052	Mouse	PMID:7766857
Biological Process	GO:1904861	excitatory synapse assembly	GRID2	IMP		Human	PMID:27418511
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Grid2	IGI	UniProtKB:Q9R171	Mouse	MGI:MGI:4839424|PMID:20537373
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	GRID2	IMP		Human	PMID:27418511
Biological Process	GO:0051965	positive regulation of synapse assembly	GRID2	IMP		Human	PMID:27418511
Biological Process	GO:0060134	prepulse inhibition	Grid2	IMP	MGI:MGI:2178052	Mouse	PMID:11488959
Biological Process	GO:0008104	protein localization	Grid2	IDA		Mouse	MGI:MGI:3852309|PMID:15207857
Biological Process	GO:0043523	regulation of neuron apoptotic process	Grid2	IMP	MGI:MGI:1857337	Mouse	PMID:10884318
Biological Process	GO:0043523	regulation of neuron apoptotic process	Grid2	IGI	MGI:MGI:99702	Mouse	PMID:10884318
Biological Process	GO:0010975	regulation of neuron projection development	Grid2	IMP	MGI:MGI:1857337	Mouse	PMID:7891151
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Grid2	IDA		Mouse	PMID:20395510
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Grid2	IMP		Mouse	PMID:20395510
Biological Process	GO:1905606	regulation of presynapse assembly	Grid2	IDA		Rat	PMID:20395510|RGD:13702347
Biological Process	GO:1905606	regulation of presynapse assembly	Grid2	IMP		Rat	PMID:20395510|RGD:13702347
Biological Process	GO:1905606	regulation of presynapse assembly	Grid2	IDA		Rat	PMID:21410790|RGD:13702257
Biological Process	GO:1905606	regulation of presynapse assembly	Grid2	IMP		Rat	PMID:21410790|RGD:13702257
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grid2	IMP	MGI:MGI:2178052	Mouse	PMID:7766857

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern