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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grik2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grik2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005234extracellularly glutamate-gated ion channel activityGRIK2IMPHumanPMID:28180184
Molecular FunctionGO:0008066glutamate receptor activityGrik2IDARatPMID:10627597|RGD:8553571
Molecular FunctionGO:0042802identical protein bindingGrik2IDARatPMID:1648177|RGD:69852
Molecular FunctionGO:0042802identical protein bindingGrik2IPIRGD:2733RatPMID:1648177|RGD:69852
Molecular FunctionGO:0042802identical protein bindingGrik2IPIUniProtKB:P42260RatPMID:17115050|RGD:13432262
Molecular FunctionGO:0042802identical protein bindingGrik2IPIUniProtKB:P42260RatPMID:19465914|RGD:13432328
Molecular FunctionGO:0042802identical protein bindingGrik2IPIUniProtKB:P42260RatPMID:19617541|RGD:13432236
Molecular FunctionGO:0042802identical protein bindingGrik2IPIUniProtKB:P42260RatPMID:20404149|RGD:13432256
Molecular FunctionGO:0042802identical protein bindingGrik2IPIUniProtKB:P42260RatPMID:25119039|RGD:13432242
Molecular FunctionGO:0004970ionotropic glutamate receptor activityGrik2IMPMouseMGI:MGI:3690189|PMID:16354929
Molecular FunctionGO:0004970ionotropic glutamate receptor activityGrik2IDAMouseMGI:MGI:6414684|PMID:31474366
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGRIK2IDAHumanPMID:15537878
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:10704492
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IDAMousePMID:1310861
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IDAMousePMID:15483117
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:15509753
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IGIMGI:MGI:95814MousePMID:11985817
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:12223554
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:11985817
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IDAMousePMID:12151522
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMousePMID:12223554
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:9580260
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IGIMGI:MGI:95818MousePMID:1310861
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IMPMGI:MGI:1857979MousePMID:9880586
Molecular FunctionGO:0015277kainate selective glutamate receptor activityGrik2IDARatPMID:1648177|RGD:69852
Molecular FunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGrik2IDAMousePMID:17620617
Molecular FunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGrik2IEPMousePMID:17620617
Molecular FunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGrik2IMPMousePMID:17620617
Molecular FunctionGO:0030165PDZ domain bindingGrik2IPIUniProtKB:P31016RatPMID:1127911|RGD:8553546
Molecular FunctionGO:0030165PDZ domain bindingGrik2IPIUniProtKB:Q62696RatPMID:1127911|RGD:8553546
Molecular FunctionGO:0030165PDZ domain bindingGrik2IPIUniProtKB:P31016RatPMID:9808460|RGD:8554157
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:P21279|UniProtKB:P31016MouseMGI:MGI:3690189|PMID:16354929
Molecular FunctionGO:0005515protein bindingGrik2IPIPR:Q8BNJ6MousePMID:21734292
Molecular FunctionGO:0005515protein bindingGrik2IPIPR:Q8R4I7MousePMID:21734292
Molecular FunctionGO:0005515protein bindingGrik2IPIPR:Q8BMF5MousePMID:12954862
Molecular FunctionGO:0005515protein bindingGrik2IPIRGD:1307709RatPMID:12597860|RGD:152995391
Molecular FunctionGO:0005515protein bindingGrik2IPIRGD:621667RatPMID:12597860|RGD:152995391
Molecular FunctionGO:0005515protein bindingGrik2IPIRGD:68424RatPMID:12597860|RGD:152995391
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:Q8K430RatPMID:17062563|RGD:8553595
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:O70260RatPMID:17486098|RGD:1642482
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:P63281RatPMID:17486098|RGD:1642482
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:Q5I0H3RatPMID:17486098|RGD:1642482
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:Q5I0H3RatPMID:22089239|RGD:13432300
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:Q5I0H3RatPMID:22483987|RGD:8554830
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:Q66HA1RatPMID:22483987|RGD:8554830
Molecular FunctionGO:0005515protein bindingGrik2IPIUniProtKB:P31016RatPMID:9808460|RGD:8554157
Molecular FunctionGO:0097110scaffold protein bindingGrik2IDARatPMID:12597860|RGD:152995391
Molecular FunctionGO:0000149SNARE bindingGrik2IPIRGD:69437RatPMID:12597860|RGD:152995391
Molecular FunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGrik2IDAMousePMID:22345355
Molecular FunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGrik2IMPMousePMID:22345355
Molecular FunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGrik2EXPMousePMID:22345355
Molecular FunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGrik2IDAMousePMID:9580260
Molecular FunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGrik2IMPMousePMID:9580260
Molecular FunctionGO:0031624ubiquitin conjugating enzyme bindingGrik2IPIRGD:3926RatPMID:17486098|RGD:1642482
Molecular FunctionGO:0031625ubiquitin protein ligase bindingGrik2IPIRGD:708413RatPMID:17486098|RGD:1642482
Cellular ComponentGO:0030424axonGrik2IDARatPMID:15844209|RGD:1642495
Cellular ComponentGO:0030425dendriteGrik2IDARatPMID:16360275|RGD:1642473
Cellular ComponentGO:0030425dendriteGrik2IDARatPMID:17486098|RGD:1642482
Cellular ComponentGO:0030425dendriteGrik2IDARatPMID:9808460|RGD:8554157
Cellular ComponentGO:0032839dendrite cytoplasmGrik2IDARatPMID:15844209|RGD:1642495
Cellular ComponentGO:0098978glutamatergic synapseGrik2IDAMousePMID:17620617
Cellular ComponentGO:0098978glutamatergic synapseGrik2IEPMousePMID:17620617
Cellular ComponentGO:0098978glutamatergic synapseGrik2IMPMousePMID:17620617
Cellular ComponentGO:0098978glutamatergic synapseGrik2IMPMousePMID:27346345
Cellular ComponentGO:0098978glutamatergic synapseGrik2IDAMousePMID:27346345
Cellular ComponentGO:0098686hippocampal mossy fiber to CA3 synapseGrik2EXPMousePMID:22345355
Cellular ComponentGO:0098686hippocampal mossy fiber to CA3 synapseGrik2IDAMousePMID:22345355
Cellular ComponentGO:0098686hippocampal mossy fiber to CA3 synapseGrik2IMPMousePMID:22345355
Cellular ComponentGO:0098686hippocampal mossy fiber to CA3 synapseGrik2IDAMousePMID:9580260
Cellular ComponentGO:0098686hippocampal mossy fiber to CA3 synapseGrik2IMPMousePMID:9580260
Cellular ComponentGO:0008328ionotropic glutamate receptor complexGrik2IDARatPMID:10627597|RGD:8553571
Cellular ComponentGO:0032983kainate selective glutamate receptor complexGrik2IPIPR:Q8BMF5MousePMID:12954862
Cellular ComponentGO:0032983kainate selective glutamate receptor complexGrik2IPIPR:Q61626MousePMID:17174564
Cellular ComponentGO:0032983kainate selective glutamate receptor complexGrik2IPIPR:Q61626MousePMID:12954862
Cellular ComponentGO:0032983kainate selective glutamate receptor complexGrik2IPIPR:Q60934MousePMID:17174564
Cellular ComponentGO:0016020membraneGrik2IDAMousePMID:12954862
Cellular ComponentGO:0097471mossy fiber rosetteGrik2IDAMousePMID:27346345
Cellular ComponentGO:0097471mossy fiber rosetteGrik2IMPMousePMID:27346345
Cellular ComponentGO:0043025neuronal cell bodyGrik2IDAMousePMID:9141074
Cellular ComponentGO:0043204perikaryonGrik2IDARatPMID:15844209|RGD:1642495
Cellular ComponentGO:0005886plasma membraneGrik2IDARatPMID:9808460|RGD:8554157
Cellular ComponentGO:0014069postsynaptic densityGrik2IDAMousePMID:21734292
Cellular ComponentGO:0045211postsynaptic membraneGrik2IDAMousePMID:14724198
Cellular ComponentGO:0045211postsynaptic membraneGrik2IDAMousePMID:27346345
Cellular ComponentGO:0045211postsynaptic membraneGrik2IMPMousePMID:27346345
Cellular ComponentGO:0042734presynaptic membraneGrik2IDAMousePMID:14724198
Cellular ComponentGO:0042734presynaptic membraneGrik2IDAMousePMID:11985817
Cellular ComponentGO:0045202synapseGrik2IDAMousePMID:21734292
Cellular ComponentGO:0045202synapseGrik2IDARatPMID:17486098|RGD:1642482
Cellular ComponentGO:0043195terminal boutonGrik2IDARatPMID:15844209|RGD:1642495
Biological ProcessGO:0001662behavioral fear responseGrik2IMPMGI:MGI:1857979MousePMID:15673679
Biological ProcessGO:0007268chemical synaptic transmissionGrik2IGIMGI:MGI:95814MousePMID:15928066
Biological ProcessGO:0007268chemical synaptic transmissionGrik2IMPMGI:MGI:1857979MousePMID:15928066
Biological ProcessGO:0007268chemical synaptic transmissionGrik2IMPRatPMID:1648177|RGD:69852
Biological ProcessGO:0120169detection of cold stimulus involved in thermoceptionGrik2IMPMouseMGI:MGI:6414684|PMID:31474366
Biological ProcessGO:0120169detection of cold stimulus involved in thermoceptiongrik2IMPZFIN:ZDB-GENO-230302-7ZfishPMID:36011351
Biological ProcessGO:0060079excitatory postsynaptic potentialGrik2IGIMGI:MGI:95814MousePMID:11985817
Biological ProcessGO:0060079excitatory postsynaptic potentialGrik2IMPMGI:MGI:1857979MousePMID:11069933
Biological ProcessGO:0060079excitatory postsynaptic potentialGrik2IMPMGI:MGI:1857979MousePMID:14724198
Biological ProcessGO:0060080inhibitory postsynaptic potentialGrik2IMPMGI:MGI:1857979MousePMID:9880586
Biological ProcessGO:0060080inhibitory postsynaptic potentialGrik2IGIMGI:MGI:99402MousePMID:10704492
Biological ProcessGO:0060080inhibitory postsynaptic potentialGrik2IMPMGI:MGI:1857979MousePMID:12223554
Biological ProcessGO:0060080inhibitory postsynaptic potentialGrik2IMPMGI:MGI:1857979MousePMID:10704492
Biological ProcessGO:0060080inhibitory postsynaptic potentialGrik2IGIMGI:MGI:95814MousePMID:11144357
Biological ProcessGO:0006874intracellular calcium ion homeostasisGrik2IMPMGI:MGI:1857979MousePMID:16219388
Biological ProcessGO:0050804modulation of chemical synaptic transmissionGRIK2IDAHumanPMID:15537878
Biological ProcessGO:0098815modulation of excitatory postsynaptic potentialGrik2IMPRatPMID:12597860|RGD:152995391
Biological ProcessGO:0043524negative regulation of neuron apoptotic processGrik2IGIMGI:MGI:95819MousePMID:10479699
Biological ProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGrik2IGIMGI:MGI:95814MousePMID:11985817
Biological ProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGrik2IDARatPMID:16420445|RGD:8554693
Biological ProcessGO:0051402neuron apoptotic processGrik2IGIMGI:MGI:95819MousePMID:10479699
Biological ProcessGO:0051402neuron apoptotic processGrik2IMPRatPMID:11152698|RGD:8554109
Biological ProcessGO:0019228neuronal action potentialGrik2IMPMGI:MGI:1857979MousePMID:15539395
Biological ProcessGO:0043525positive regulation of neuron apoptotic processGrik2IMPRatPMID:17639597|RGD:2316528
Biological ProcessGO:0050806positive regulation of synaptic transmissionGRIK2IMPHumanPMID:15537878
Biological ProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGrik2IGIMGI:MGI:95814MousePMID:11985817
Biological ProcessGO:0043113receptor clusteringGrik2IDARatPMID:9808460|RGD:8554157
Biological ProcessGO:0046328regulation of JNK cascadeGrik2IMPRatPMID:11152698|RGD:8554109
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityGrik2IMPMGI:MGI:1857979MousePMID:16219388
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityGrik2IMPMGI:MGI:1857979MousePMID:15673679
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityGrik2IMPMGI:MGI:1857979MousePMID:12947409
Biological ProcessGO:0048169regulation of long-term neuronal synaptic plasticityGrik2IMPMGI:MGI:1857979MousePMID:11182092
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMGI:MGI:1857979MousePMID:10704492
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMGI:MGI:1857979MousePMID:9490692
Biological ProcessGO:0042391regulation of membrane potentialGrik2IGIMGI:MGI:95818MousePMID:1310861
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMGI:MGI:1857979MousePMID:15513934
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMousePMID:12223554
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMGI:MGI:1857979MousePMID:15509753
Biological ProcessGO:0042391regulation of membrane potentialGrik2IDAMousePMID:12151522
Biological ProcessGO:0042391regulation of membrane potentialGrik2IMPMGI:MGI:1857979MousePMID:16219388
Biological ProcessGO:0042391regulation of membrane potentialGrik2IDAMousePMID:1310861
Biological ProcessGO:0048172regulation of short-term neuronal synaptic plasticityGRIK2IMPHumanPMID:15537878
Biological ProcessGO:0048172regulation of short-term neuronal synaptic plasticityGrik2IMPMGI:MGI:1857979MousePMID:11182092
Biological ProcessGO:0009409response to coldgrik2IMPZFIN:ZDB-GENO-230302-7ZfishPMID:36011351
Biological ProcessGO:0035249synaptic transmission, glutamatergicGrik2IMPMGI:MGI:1857979MousePMID:15509753
Biological ProcessGO:0035249synaptic transmission, glutamatergicGrik2IMPMGI:MGI:1857979MousePMID:9580260

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory