Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grik2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GRIK2
- Mouse genes Grik2
- Rat genes Grik2
- Zfish genes grik2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grik2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005234	extracellularly glutamate-gated ion channel activity	GRIK2	IMP		Human	PMID:28180184
Molecular Function	GO:0008066	glutamate receptor activity	Grik2	IDA		Rat	PMID:10627597\|RGD:8553571
Molecular Function	GO:0042802	identical protein binding	Grik2	IDA		Rat	PMID:1648177\|RGD:69852
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	RGD:2733	Rat	PMID:1648177\|RGD:69852
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	UniProtKB:P42260	Rat	PMID:17115050\|RGD:13432262
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	UniProtKB:P42260	Rat	PMID:19465914\|RGD:13432328
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	UniProtKB:P42260	Rat	PMID:19617541\|RGD:13432236
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	UniProtKB:P42260	Rat	PMID:20404149\|RGD:13432256
Molecular Function	GO:0042802	identical protein binding	Grik2	IPI	UniProtKB:P42260	Rat	PMID:25119039\|RGD:13432242
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	Grik2	IMP		Mouse	MGI:MGI:3690189\|PMID:16354929
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	Grik2	IDA		Mouse	MGI:MGI:6414684\|PMID:31474366
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	GRIK2	IDA		Human	PMID:15537878
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:10704492
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IDA		Mouse	PMID:1310861
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IDA		Mouse	PMID:15483117
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15509753
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:11985817
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:12223554
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:11985817
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IDA		Mouse	PMID:12151522
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP		Mouse	PMID:12223554
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:9580260
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IGI	MGI:MGI:95818	Mouse	PMID:1310861
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:9880586
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik2	IDA		Rat	PMID:1648177\|RGD:69852
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grik2	IDA		Mouse	PMID:17620617
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grik2	IEP		Mouse	PMID:17620617
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grik2	IMP		Mouse	PMID:17620617
Molecular Function	GO:0030165	PDZ domain binding	Grik2	IPI	UniProtKB:P31016	Rat	PMID:1127911\|RGD:8553546
Molecular Function	GO:0030165	PDZ domain binding	Grik2	IPI	UniProtKB:Q62696	Rat	PMID:1127911\|RGD:8553546
Molecular Function	GO:0030165	PDZ domain binding	Grik2	IPI	UniProtKB:P31016	Rat	PMID:9808460\|RGD:8554157
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:P21279\|UniProtKB:P31016	Mouse	MGI:MGI:3690189\|PMID:16354929
Molecular Function	GO:0005515	protein binding	Grik2	IPI	PR:Q8BNJ6	Mouse	PMID:21734292
Molecular Function	GO:0005515	protein binding	Grik2	IPI	PR:Q8R4I7	Mouse	PMID:21734292
Molecular Function	GO:0005515	protein binding	Grik2	IPI	PR:Q8BMF5	Mouse	PMID:12954862
Molecular Function	GO:0005515	protein binding	Grik2	IPI	RGD:1307709	Rat	PMID:12597860\|RGD:152995391
Molecular Function	GO:0005515	protein binding	Grik2	IPI	RGD:621667	Rat	PMID:12597860\|RGD:152995391
Molecular Function	GO:0005515	protein binding	Grik2	IPI	RGD:68424	Rat	PMID:12597860\|RGD:152995391
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:Q8K430	Rat	PMID:17062563\|RGD:8553595
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:O70260	Rat	PMID:17486098\|RGD:1642482
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:P63281	Rat	PMID:17486098\|RGD:1642482
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:Q5I0H3	Rat	PMID:17486098\|RGD:1642482
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:Q5I0H3	Rat	PMID:22089239\|RGD:13432300
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:Q5I0H3	Rat	PMID:22483987\|RGD:8554830
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:Q66HA1	Rat	PMID:22483987\|RGD:8554830
Molecular Function	GO:0005515	protein binding	Grik2	IPI	UniProtKB:P31016	Rat	PMID:9808460\|RGD:8554157
Molecular Function	GO:0097110	scaffold protein binding	Grik2	IDA		Rat	PMID:12597860\|RGD:152995391
Molecular Function	GO:0000149	SNARE binding	Grik2	IPI	RGD:69437	Rat	PMID:12597860\|RGD:152995391
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik2	IDA		Mouse	PMID:22345355
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik2	IMP		Mouse	PMID:22345355
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik2	EXP		Mouse	PMID:22345355
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik2	IDA		Mouse	PMID:9580260
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik2	IMP		Mouse	PMID:9580260
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	Grik2	IPI	RGD:3926	Rat	PMID:17486098\|RGD:1642482
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Grik2	IPI	RGD:708413	Rat	PMID:17486098\|RGD:1642482
Cellular Component	GO:0030424	axon	Grik2	IDA		Rat	PMID:15844209\|RGD:1642495
Cellular Component	GO:0030425	dendrite	Grik2	IDA		Rat	PMID:16360275\|RGD:1642473
Cellular Component	GO:0030425	dendrite	Grik2	IDA		Rat	PMID:17486098\|RGD:1642482
Cellular Component	GO:0030425	dendrite	Grik2	IDA		Rat	PMID:9808460\|RGD:8554157
Cellular Component	GO:0032839	dendrite cytoplasm	Grik2	IDA		Rat	PMID:15844209\|RGD:1642495
Cellular Component	GO:0098978	glutamatergic synapse	Grik2	IDA		Mouse	PMID:17620617
Cellular Component	GO:0098978	glutamatergic synapse	Grik2	IEP		Mouse	PMID:17620617
Cellular Component	GO:0098978	glutamatergic synapse	Grik2	IMP		Mouse	PMID:17620617
Cellular Component	GO:0098978	glutamatergic synapse	Grik2	IMP		Mouse	PMID:27346345
Cellular Component	GO:0098978	glutamatergic synapse	Grik2	IDA		Mouse	PMID:27346345
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik2	EXP		Mouse	PMID:22345355
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik2	IDA		Mouse	PMID:22345355
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik2	IMP		Mouse	PMID:22345355
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik2	IDA		Mouse	PMID:9580260
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik2	IMP		Mouse	PMID:9580260
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	Grik2	IDA		Rat	PMID:10627597\|RGD:8553571
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik2	IPI	PR:Q8BMF5	Mouse	PMID:12954862
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik2	IPI	PR:Q61626	Mouse	PMID:17174564
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik2	IPI	PR:Q61626	Mouse	PMID:12954862
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik2	IPI	PR:Q60934	Mouse	PMID:17174564
Cellular Component	GO:0016020	membrane	Grik2	IDA		Mouse	PMID:12954862
Cellular Component	GO:0097471	mossy fiber rosette	Grik2	IDA		Mouse	PMID:27346345
Cellular Component	GO:0097471	mossy fiber rosette	Grik2	IMP		Mouse	PMID:27346345
Cellular Component	GO:0043025	neuronal cell body	Grik2	IDA		Mouse	PMID:9141074
Cellular Component	GO:0043204	perikaryon	Grik2	IDA		Rat	PMID:15844209\|RGD:1642495
Cellular Component	GO:0005886	plasma membrane	Grik2	IDA		Rat	PMID:9808460\|RGD:8554157
Cellular Component	GO:0014069	postsynaptic density	Grik2	IDA		Mouse	PMID:21734292
Cellular Component	GO:0045211	postsynaptic membrane	Grik2	IDA		Mouse	PMID:14724198
Cellular Component	GO:0045211	postsynaptic membrane	Grik2	IDA		Mouse	PMID:27346345
Cellular Component	GO:0045211	postsynaptic membrane	Grik2	IMP		Mouse	PMID:27346345
Cellular Component	GO:0042734	presynaptic membrane	Grik2	IDA		Mouse	PMID:14724198
Cellular Component	GO:0042734	presynaptic membrane	Grik2	IDA		Mouse	PMID:11985817
Cellular Component	GO:0045202	synapse	Grik2	IDA		Mouse	PMID:21734292
Cellular Component	GO:0045202	synapse	Grik2	IDA		Rat	PMID:17486098\|RGD:1642482
Cellular Component	GO:0043195	terminal bouton	Grik2	IDA		Rat	PMID:15844209\|RGD:1642495
Biological Process	GO:0001662	behavioral fear response	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15673679
Biological Process	GO:0007268	chemical synaptic transmission	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:15928066
Biological Process	GO:0007268	chemical synaptic transmission	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15928066
Biological Process	GO:0007268	chemical synaptic transmission	Grik2	IMP		Rat	PMID:1648177\|RGD:69852
Biological Process	GO:0120169	detection of cold stimulus involved in thermoception	Grik2	IMP		Mouse	MGI:MGI:6414684\|PMID:31474366
Biological Process	GO:0120169	detection of cold stimulus involved in thermoception	grik2	IMP	ZFIN:ZDB-GENO-230302-7	Zfish	PMID:36011351
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:11985817
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:11069933
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:14724198
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:9880586
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik2	IGI	MGI:MGI:99402	Mouse	PMID:10704492
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:12223554
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:10704492
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:11144357
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:16219388
Biological Process	GO:0050804	modulation of chemical synaptic transmission	GRIK2	IDA		Human	PMID:15537878
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	Grik2	IMP		Rat	PMID:12597860\|RGD:152995391
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Grik2	IGI	MGI:MGI:95819	Mouse	PMID:10479699
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:11985817
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Grik2	IDA		Rat	PMID:16420445\|RGD:8554693
Biological Process	GO:0051402	neuron apoptotic process	Grik2	IGI	MGI:MGI:95819	Mouse	PMID:10479699
Biological Process	GO:0051402	neuron apoptotic process	Grik2	IMP		Rat	PMID:11152698\|RGD:8554109
Biological Process	GO:0019228	neuronal action potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15539395
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Grik2	IMP		Rat	PMID:17639597\|RGD:2316528
Biological Process	GO:0050806	positive regulation of synaptic transmission	GRIK2	IMP		Human	PMID:15537878
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grik2	IGI	MGI:MGI:95814	Mouse	PMID:11985817
Biological Process	GO:0043113	receptor clustering	Grik2	IDA		Rat	PMID:9808460\|RGD:8554157
Biological Process	GO:0046328	regulation of JNK cascade	Grik2	IMP		Rat	PMID:11152698\|RGD:8554109
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:16219388
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15673679
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:12947409
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:11182092
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:10704492
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:9490692
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IGI	MGI:MGI:95818	Mouse	PMID:1310861
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15513934
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP		Mouse	PMID:12223554
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15509753
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IDA		Mouse	PMID:12151522
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:16219388
Biological Process	GO:0042391	regulation of membrane potential	Grik2	IDA		Mouse	PMID:1310861
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	GRIK2	IMP		Human	PMID:15537878
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:11182092
Biological Process	GO:0009409	response to cold	grik2	IMP	ZFIN:ZDB-GENO-230302-7	Zfish	PMID:36011351
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:15509753
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik2	IMP	MGI:MGI:1857979	Mouse	PMID:9580260

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.