Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRIK5
  • Mouse genes Grik5
  • Rat genes Grik5
  • Zfish genes grik5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grik5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008066	glutamate receptor activity	Grik5	IDA		Rat	PMID:10627597|RGD:8553571
Molecular Function	GO:0042802	identical protein binding	Grik5	IPI	UniProtKB:Q63273	Rat	PMID:12878702|RGD:2316545
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	GRIK5	IDA		Human	PMID:1321949
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik5	IGI	MGI:MGI:95815	Mouse	PMID:1310861
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik5	IDA		Rat	PMID:12080343|RGD:625595
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK5	IDA		Human	PMID:18562611
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK5	IMP		Human	PMID:18562611
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK5	IDA		Human	PMID:20026616
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK5	IMP		Human	PMID:20026616
Molecular Function	GO:0030165	PDZ domain binding	Grik5	IPI	UniProtKB:P31016	Rat	PMID:1127911|RGD:8553546
Molecular Function	GO:0005515	protein binding	Grik5	IPI	UniProtKB:P21279	Mouse	MGI:MGI:3690189|PMID:16354929
Molecular Function	GO:0005515	protein binding	Grik5	IPI	PR:Q62188	Mouse	PMID:24227739
Molecular Function	GO:0005515	protein binding	Grik5	IPI	PR:O08553	Mouse	PMID:24227739
Molecular Function	GO:0005515	protein binding	Grik5	IPI	RGD:1359261|RGD:68424	Rat	PMID:17639597|RGD:2316528
Molecular Function	GO:0017124	SH3 domain binding	Grik5	IMP		Rat	PMID:1127911|RGD:8553546
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik5	EXP		Mouse	PMID:22345355
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik5	IMP		Mouse	PMID:22345355
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grik5	IDA		Mouse	PMID:22345355
Cellular Component	GO:0030424	axon	Grik5	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0030425	dendrite	Grik5	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0030425	dendrite	Grik5	IDA		Rat	PMID:9808460|RGD:8554157
Cellular Component	GO:0005783	endoplasmic reticulum	Grik5	IDA		Mouse	PMID:16814779
Cellular Component	GO:0098978	glutamatergic synapse	Grik5	IDA		Rat	PMID:16360275|RGD:1642473
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik5	IDA		Mouse	PMID:12954862
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik5	EXP		Mouse	PMID:22345355
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik5	IDA		Mouse	PMID:22345355
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grik5	IMP		Mouse	PMID:22345355
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	Grik5	IDA		Rat	PMID:10627597|RGD:8553571
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik5	IPI	PR:Q60934	Mouse	PMID:17174564
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik5	IPI	PR:P39087	Mouse	PMID:12954862
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik5	IPI	PR:Q8BMF5	Mouse	PMID:12954862
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik5	IPI	PR:P39087	Mouse	PMID:17174564
Cellular Component	GO:0016020	membrane	Grik5	IDA		Mouse	PMID:12954862
Cellular Component	GO:0043005	neuron projection	Grik5	IDA		Rat	PMID:16903873|RGD:2316535
Cellular Component	GO:0043025	neuronal cell body	Grik5	IDA		Rat	PMID:18096442|RGD:2316525
Cellular Component	GO:0005654	nucleoplasm	GRIK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Grik5	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0005886	plasma membrane	GRIK5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Grik5	IDA		Rat	PMID:11226670|RGD:5147998
Cellular Component	GO:0098839	postsynaptic density membrane	Grik5	IDA		Mouse	PMID:12954862
Cellular Component	GO:0045211	postsynaptic membrane	Grik5	IDA		Mouse	PMID:12954862
Cellular Component	GO:0045211	postsynaptic membrane	Grik5	IDA		Rat	PMID:16903873|RGD:2316535
Cellular Component	GO:0042734	presynaptic membrane	Grik5	IDA		Mouse	PMID:12954862
Cellular Component	GO:0042734	presynaptic membrane	Grik5	IDA		Rat	PMID:16360275|RGD:1642473
Cellular Component	GO:0042734	presynaptic membrane	Grik5	IDA		Rat	PMID:16903873|RGD:2316535
Cellular Component	GO:0043195	terminal bouton	Grik5	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0043195	terminal bouton	Grik5	IDA		Rat	PMID:16360275|RGD:1642473
Biological Process	GO:0071333	cellular response to glucose stimulus	Grik5	IEP		Rat	PMID:16936133|RGD:2316533
Biological Process	GO:0007268	chemical synaptic transmission	Grik5	IDA		Mouse	MGI:MGI:6201930|PMID:22345355
Biological Process	GO:0007268	chemical synaptic transmission	Grik5	IDA		Rat	PMID:12080343|RGD:625595
Biological Process	GO:0099565	chemical synaptic transmission, postsynaptic	Grik5	IDA		Mouse	MGI:MGI:6201930|PMID:22345355
Biological Process	GO:0051649	establishment of localization in cell	Grik5	IMP		Rat	PMID:12878702|RGD:2316545
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik5	IMP	MGI:MGI:2668206	Mouse	PMID:12533602
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Grik5	IDA		Mouse	MGI:MGI:6201930|PMID:22345355
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Grik5	IMP		Rat	PMID:17639597|RGD:2316528
Biological Process	GO:0006621	protein retention in ER lumen	Grik5	IMP		Rat	PMID:12878702|RGD:2316545
Biological Process	GO:0043113	receptor clustering	Grik5	IDA		Rat	PMID:9808460|RGD:8554157
Biological Process	GO:0042391	regulation of membrane potential	Grik5	IGI	MGI:MGI:95815	Mouse	PMID:1310861
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Grik5	IDA		Mouse	MGI:MGI:6201930|PMID:22345355
Biological Process	GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	Grik5	IMP	MGI:MGI:2668206	Mouse	PMID:12533602
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik5	IMP	MGI:MGI:2668206	Mouse	PMID:12533602

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern