Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grin2d

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GRIN2D
- Mouse genes Grin2d
- Rat genes Grin2d
- Zfish genes grin2da
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grin2d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016595	glutamate binding	Grin2d	IMP		Rat	PMID:15107472\|RGD:1642397
Molecular Function	GO:0022849	glutamate-gated calcium ion channel activity	GRIN2D	IDA		Human	PMID:26875626
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	GRIN2D	IDA		Human	PMID:27616483
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	Grin2d	IDA		Rat	PMID:7512349\|RGD:728580
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grin2d	IDA		Rat	PMID:8886398\|RGD:155230782
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grin2d	IMP		Rat	PMID:8886398\|RGD:155230782
Molecular Function	GO:0005261	monoatomic cation channel activity	Grin2d	IDA		Rat	PMID:7512349\|RGD:728580
Molecular Function	GO:0042165	neurotransmitter binding	Grin2d	IMP		Rat	PMID:15107472\|RGD:1642397
Molecular Function	GO:0004972	NMDA glutamate receptor activity	GRIN2D	IDA		Human	PMID:26919761
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IDA		Mouse	PMID:1385220
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IMP	MGI:MGI:1928298	Mouse	PMID:12832518
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IMP		Rat	PMID:15107472\|RGD:1642397
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IMP		Rat	PMID:17050728\|RGD:1642380
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IMP		Rat	PMID:23625947\|RGD:13432339
Molecular Function	GO:0004972	NMDA glutamate receptor activity	Grin2d	IDA		Rat	PMID:7512349\|RGD:728580
Molecular Function	GO:0005515	protein binding	GRIN2D	IPI	UniProtKB:Q62936	Human	PMID:11937501
Molecular Function	GO:0005515	protein binding	Grin2d	IPI	UniProtKB:Q63ZW7	Rat	PMID:9647694\|RGD:8553765
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grin2d	EXP		Rat	PMID:18987204\|RGD:13792536
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Grin2d	IDA		Rat	PMID:18987204\|RGD:13792536
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	Grin2d	IMP		Rat	PMID:17050728\|RGD:1642380
Cellular Component	GO:0098978	glutamatergic synapse	Grin2d	EXP		Rat	PMID:18987204\|RGD:13792536
Cellular Component	GO:0098978	glutamatergic synapse	Grin2d	IDA		Rat	PMID:18987204\|RGD:13792536
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Grin2d	IDA		Rat	PMID:23159309\|RGD:13702288
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	GRIN2D	IDA		Human	PMID:26875626
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	GRIN2D	IDA		Human	PMID:26919761
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	Grin2d	IDA		Rat	PMID:17050728\|RGD:1642380
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	Grin2d	IDA		Rat	PMID:23625947\|RGD:13432339
Cellular Component	GO:0005886	plasma membrane	GRIN2D	IDA		Human	PMID:26875626
Cellular Component	GO:0005886	plasma membrane	GRIN2D	IDA		Human	PMID:26919761
Cellular Component	GO:0005886	plasma membrane	Grin2d	IDA		Rat	PMID:23625947\|RGD:13432339
Cellular Component	GO:0098839	postsynaptic density membrane	Grin2d	IDA		Rat	PMID:23159309\|RGD:13702288
Cellular Component	GO:0048787	presynaptic active zone membrane	Grin2d	IDA		Rat	PMID:23159309\|RGD:13702288
Cellular Component	GO:0045202	synapse	Grin2d	IDA		Mouse	PMID:8774946
Biological Process	GO:0008344	adult locomotory behavior	Grin2d	IMP	MGI:MGI:1928298	Mouse	PMID:8774946
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	GRIN2D	IDA		Human	PMID:26875626
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	Grin2d	IDA		Rat	PMID:19793963\|RGD:150521643
Biological Process	GO:0098655	monoatomic cation transmembrane transport	Grin2d	IDA		Rat	PMID:22246434\|RGD:150521639
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Grin2d	IDA		Rat	PMID:19793963\|RGD:150521643
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Grin2d	IDA		Rat	PMID:19793963\|RGD:150521643
Biological Process	GO:1904062	regulation of monoatomic cation transmembrane transport	Grin2d	IDA		Rat	PMID:19793963\|RGD:150521643
Biological Process	GO:0051930	regulation of sensory perception of pain	Grin2d	IMP	MGI:MGI:1928298	Mouse	PMID:10771345
Biological Process	GO:0001964	startle response	Grin2d	IMP	MGI:MGI:1928298	Mouse	PMID:11488959
Biological Process	GO:0001964	startle response	Grin2d	IMP	MGI:MGI:1928298	Mouse	PMID:9718984
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grin2d	IMP		Rat	PMID:15107472\|RGD:1642397

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.