Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRK2
  • Mouse genes Grk2
  • Rat genes Grk2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Molecular Function	GO:0031850	delta-type opioid receptor binding	Grk2	IPI	RGD:3233	Rat	PMID:28381559|RGD:13513978
Molecular Function	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	GRK2	IDA		Human	PMID:19306925
Molecular Function	GO:0001664	G protein-coupled receptor binding	Grk2	IPI	RGD:1589785	Rat	PMID:26228571|RGD:11076228
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	GRK2	IMP		Human	PMID:15102938
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk2	IMP	MGI:MGI:2180127	Mouse	PMID:8917529
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk2	IDA		Mouse	PMID:1869533
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk2	IDA		Mouse	PMID:14712229
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Molecular Function	GO:0031851	kappa-type opioid receptor binding	Grk2	IPI	RGD:69426	Rat	PMID:27865836|RGD:13513990
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P0CG48	Human	PMID:17006543
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:Q00987	Human	PMID:17006543
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P25103	Human	PMID:17986524
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:Q9Y2X7	Human	PMID:18369319
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P25963	Human	PMID:19008357
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P11233	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:Q92633	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:Q9HBW0	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:Q13635	Human	PMID:19502428
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P21462	Human	PMID:22447027
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P35626	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P35626	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P13591	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P21860	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GRK2	IPI	UniProtKB:P48730-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Grk2	IPI	PR:Q01338	Mouse	PMID:15218143
Molecular Function	GO:0005515	protein binding	Grk2	IPI	PR:Q8CFI0	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Grk2	IPI	PR:P30545	Mouse	PMID:15218143
Molecular Function	GO:0005515	protein binding	Grk2	IPI	PR:P46935	Mouse	PMID:17544362
Molecular Function	GO:0005515	protein binding	Grk2	IPI	RGD:2280	Rat	PMID:15626685|RGD:1582266
Molecular Function	GO:0005515	protein binding	Grk2	IPI	RGD:62017	Rat	PMID:27568556|RGD:13513994
Molecular Function	GO:0004672	protein kinase activity	Grk2	IDA		Mouse	PMID:15218143
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Grk2	IDA		Mouse	PMID:17544362
Molecular Function	GO:0097110	scaffold protein binding	Grk2	IPI	RGD:2280	Rat	PMID:28162981|RGD:13513989
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Grk2	IPI	RGD:1305332	Rat	PMID:26228571|RGD:11076228
Cellular Component	GO:0016324	apical plasma membrane	Grk2	IDA		Rat	PMID:16899567|RGD:4140424
Cellular Component	GO:0030424	axon	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0016323	basolateral plasma membrane	Grk2	IDA		Rat	PMID:16899567|RGD:4140424
Cellular Component	GO:0005901	caveola	Grk2	IDA		Rat	PMID:15626685|RGD:1582266
Cellular Component	GO:0005737	cytoplasm	GRK2	IDA		Human	PMID:17986524
Cellular Component	GO:0005737	cytoplasm	Grk2	IDA		Rat	PMID:16899567|RGD:4140424
Cellular Component	GO:0005829	cytosol	Grk2	IDA		Rat	PMID:28381559|RGD:13513978
Cellular Component	GO:0043198	dendritic shaft	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0043197	dendritic spine	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0098978	glutamatergic synapse	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0016020	membrane	GRK2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Grk2	IDA		Mouse	PMID:15218143
Cellular Component	GO:0045121	membrane raft	Grk2	IDA		Rat	PMID:29081032|RGD:13506833
Cellular Component	GO:0005739	mitochondrion	Grk2	IDA		Rat	PMID:23467820|RGD:13792779
Cellular Component	GO:0014069	postsynaptic density	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0098793	presynapse	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Cellular Component	GO:0045202	synapse	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Biological Process	GO:0007568	aging	Grk2	IEP		Rat	PMID:15626685|RGD:1582266
Biological Process	GO:0060048	cardiac muscle contraction	GRK2	IMP		Human	PMID:15051637
Biological Process	GO:0071870	cellular response to catecholamine stimulus	Grk2	IEP		Rat	PMID:26849467|RGD:11572204
Biological Process	GO:1990869	cellular response to chemokine	Grk2	IDA		Rat	PMID:23221335|RGD:13792784
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Grk2	IMP		Rat	PMID:24018045|RGD:13792711
Biological Process	GO:0071333	cellular response to glucose stimulus	Grk2	IDA		Rat	PMID:27865836|RGD:13513990
Biological Process	GO:0071407	cellular response to organic cyclic compound	Grk2	IEP		Rat	PMID:23467820|RGD:13792779
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	Grk2	IEP		Rat	PMID:29905975|RGD:13792696
Biological Process	GO:0072752	cellular response to rapamycin	Grk2	IEP		Rat	PMID:26228571|RGD:11076228
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	GRK2	IMP		Human	PMID:15102938
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk2	IGI	MGI:MGI:87937	Mouse	PMID:7761854
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk2	IMP	MGI:MGI:2180127	Mouse	PMID:10338466
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk2	IMP		Rat	PMID:17908240|RGD:7242040
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk2	IDA		Rat	PMID:18223549|RGD:8553863
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grk2	IMP		Rat	PMID:30075183|RGD:13792694
Biological Process	GO:0042699	follicle-stimulating hormone signaling pathway	Grk2	IDA		Rat	PMID:16899567|RGD:4140424
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Grk2	IDA		Mouse	PMID:14712229
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Grk2	IDA		Rat	PMID:12021252|RGD:625698
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Grk2	IEP		Rat	PMID:29081032|RGD:13506833
Biological Process	GO:0007507	heart development	Grk2	IMP	MGI:MGI:2180127	Mouse	PMID:8917529
Biological Process	GO:0051457	maintenance of protein location in nucleus	Grk2	IMP		Rat	PMID:28759639|RGD:13513977
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Grk2	IMP		Rat	PMID:30075183|RGD:13792694
Biological Process	GO:0043066	negative regulation of apoptotic process	Grk2	IMP		Rat	PMID:26849467|RGD:11572204
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	Grk2	IMP		Rat	PMID:23913704|RGD:13792716
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	Grk2	IMP		Rat	PMID:23690069|RGD:13792722
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Biological Process	GO:0046325	negative regulation of glucose import	Grk2	IMP		Rat	PMID:26660861|RGD:13514041
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Grk2	IMP		Rat	PMID:26660861|RGD:13514041
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Grk2	IMP		Rat	PMID:26660861|RGD:13514041
Biological Process	GO:1901081	negative regulation of relaxation of smooth muscle	GRK2	IMP		Human	PMID:30284927
Biological Process	GO:1901081	negative regulation of relaxation of smooth muscle	Grk2	IMP		Mouse	MGI:MGI:6280159|PMID:30284927
Biological Process	GO:0045988	negative regulation of striated muscle contraction	GRK2	IMP		Human	PMID:15051637
Biological Process	GO:0003108	negative regulation of the force of heart contraction by chemical signal	GRK2	IMP		Human	PMID:15051637
Biological Process	GO:0048709	oligodendrocyte differentiation	Grk2	IEP		Rat	PMID:24613411|RGD:13792699
Biological Process	GO:0048709	oligodendrocyte differentiation	Grk2	IMP		Rat	PMID:24613411|RGD:13792699
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Grk2	IDA		Mouse	PMID:17544362
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	Grk2	IDA		Mouse	PMID:17544362
Biological Process	GO:0033605	positive regulation of catecholamine secretion	Grk2	IDA		Rat	PMID:18223549|RGD:8553863
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Grk2	IMP		Rat	PMID:28975565|RGD:13506836
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Grk2	IMP		Rat	PMID:27862165|RGD:13513991
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Grk2	IMP		Rat	PMID:28193640|RGD:13513988
Biological Process	GO:0010661	positive regulation of muscle cell apoptotic process	Grk2	IMP		Rat	PMID:26631573|RGD:11554709
Biological Process	GO:1904058	positive regulation of sensory perception of pain	Grk2	IMP		Rat	PMID:27568556|RGD:13513994
Biological Process	GO:1904058	positive regulation of sensory perception of pain	Grk2	IMP		Rat	PMID:28975565|RGD:13506836
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Grk2	IMP		Rat	PMID:24018045|RGD:13792711
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Grk2	IMP		Rat	PMID:27773680|RGD:13513992
Biological Process	GO:0045907	positive regulation of vasoconstriction	Grk2	IMP		Rat	PMID:28882814|RGD:13506839
Biological Process	GO:0006468	protein phosphorylation	Grk2	IDA		Mouse	PMID:15218143
Biological Process	GO:0006468	protein phosphorylation	Grk2	IDA		Rat	PMID:1403099|RGD:632163
Biological Process	GO:0006468	protein phosphorylation	Grk2	IMP		Rat	PMID:23690069|RGD:13792722
Biological Process	GO:0031623	receptor internalization	GRK2	IDA		Human	PMID:20074556
Biological Process	GO:0002026	regulation of the force of heart contraction	Grk2	IGI	MGI:MGI:87937	Mouse	PMID:7761854
Biological Process	GO:0061771	response to caloric restriction	Grk2	IEP		Rat	PMID:23073237|RGD:13792788
Biological Process	GO:0042542	response to hydrogen peroxide	Grk2	IEP		Rat	PMID:16337875|RGD:1625785
Biological Process	GO:0044321	response to leptin	Grk2	IEP		Rat	PMID:23073237|RGD:13792788
Biological Process	GO:0043278	response to morphine	Grk2	IEP		Rat	PMID:29081032|RGD:13506833
Biological Process	GO:0014850	response to muscle activity	Grk2	IEP		Rat	PMID:23913704|RGD:13792716
Biological Process	GO:0014070	response to organic cyclic compound	Grk2	IDA		Rat	PMID:16478977|RGD:1625789
Biological Process	GO:0006979	response to oxidative stress	Grk2	IDA		Rat	PMID:16478977|RGD:1625789
Biological Process	GO:0007217	tachykinin receptor signaling pathway	GRK2	IDA		Human	PMID:17986524
Biological Process	GO:0042311	vasodilation	Grk2	IMP		Rat	PMID:23913704|RGD:13792716
Biological Process	GO:0046718	viral entry into host cell	GRK2	IMP		Human	PMID:23029581
Biological Process	GO:0019079	viral genome replication	GRK2	IMP		Human	PMID:23029581

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern