Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRM1
  • Mouse genes Grm1
  • Rat genes Grm1
  • Zfish genes grm1a,grm1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Grm1	EXP		Mouse	PMID:11487615
Molecular Function	GO:0098872	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Grm1	IDA		Mouse	PMID:11487615
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	Grm1	IMP		Rat	PMID:14614461|RGD:1304458
Molecular Function	GO:0008066	glutamate receptor activity	GRM1	IDA		Human	PMID:10945991
Molecular Function	GO:0008066	glutamate receptor activity	GRM1	IDA		Human	PMID:24603153
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Grm1	IMP		Mouse	MGI:MGI:4353919|PMID:19657020
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Grm1	IPI	RGD:2581	Rat	PMID:18948402|RGD:4892069
Molecular Function	GO:0005515	protein binding	GRM1	IPI	UniProtKB:P52294	Human	PMID:19084525
Molecular Function	GO:0005515	protein binding	Grm1	IPI	PR:Q9Z2Y3	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Grm1	IPI	PR:P11881	Mouse	PMID:15579147
Molecular Function	GO:0005515	protein binding	Grm1	IPI	PR:Q99JP6	Mouse	PMID:18480293
Molecular Function	GO:0005515	protein binding	Grm1	IPI	PR:Q9QWW1	Mouse	PMID:9808458
Molecular Function	GO:0005515	protein binding	Grm1	IPI	UniProtKB:P63088	Rat	PMID:14519764|RGD:8553385
Molecular Function	GO:0005515	protein binding	Grm1	IPI	RGD:628725	Rat	PMID:9069287|RGD:633021
Cellular Component	GO:0030424	axon	Grm1	IDA		Rat	PMID:11530226|RGD:8553469
Cellular Component	GO:0030425	dendrite	Grm1	IDA		Mouse	MGI:MGI:1859499|PMID:10846166
Cellular Component	GO:0043197	dendritic spine	Grm1	IDA		Rat	PMID:18582438|RGD:2303068
Cellular Component	GO:0038037	G protein-coupled receptor dimeric complex	GRM1	IDA		Human	PMID:24603153
Cellular Component	GO:0038038	G protein-coupled receptor homodimeric complex	GRM1	IPI	UniProtKB:Q13255	Human	PMID:10945991
Cellular Component	GO:0098978	glutamatergic synapse	Grm1	IDA		Mouse	PMID:11487615
Cellular Component	GO:0098978	glutamatergic synapse	Grm1	EXP		Mouse	PMID:11487615
Cellular Component	GO:0098978	glutamatergic synapse	Grm1	IDA		Rat	PMID:8104433|RGD:13702212
Cellular Component	GO:0043005	neuron projection	Grm1	IDA		Mouse	MGI:MGI:5320264|PMID:21795692
Cellular Component	GO:0005634	nucleus	Grm1	IDA		Mouse	PMID:15579147
Cellular Component	GO:0005886	plasma membrane	GRM1	IMP		Human	PMID:24603153
Cellular Component	GO:0014069	postsynaptic density	Grm1	IDA		Mouse	PMID:15579147
Cellular Component	GO:0014069	postsynaptic density	Grm1	IDA		Rat	PMID:11226670|RGD:5147998
Cellular Component	GO:0014069	postsynaptic density	Grm1	IDA		Rat	PMID:18582438|RGD:2303068
Cellular Component	GO:0098839	postsynaptic density membrane	Grm1	IDA		Rat	PMID:8104433|RGD:13702212
Cellular Component	GO:0098839	postsynaptic density membrane	Grm1	IDA		Rat	PMID:9412905|RGD:12859074
Cellular Component	GO:0045211	postsynaptic membrane	Grm1	IDA		Rat	PMID:8104433|RGD:13702212
Cellular Component	GO:0042734	presynaptic membrane	Grm1	IDA		Rat	PMID:11530226|RGD:8553469
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Grm1	IDA		Mouse	PMID:11487615
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Grm1	EXP		Mouse	PMID:11487615
Biological Process	GO:0019722	calcium-mediated signaling	Grm1	IDA		Rat	PMID:15229243|RGD:1358718
Biological Process	GO:0071257	cellular response to electrical stimulus	Grm1	IMP		Mouse	PMID:21052544
Biological Process	GO:0007268	chemical synaptic transmission	Grm1	IEP		Rat	PMID:12514201|RGD:728822
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GRM1	IMP		Human	PMID:24603153
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	Grm1	IMP		Rat	PMID:14614461|RGD:1304458
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GRM1	IDA		Human	PMID:24603153
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	GRM1	IMP		Human	PMID:28886343
Biological Process	GO:0098712	L-glutamate import across plasma membrane	Grm1	IDA		Mouse	PMID:15140926
Biological Process	GO:0007626	locomotory behavior	Grm1	IMP		Mouse	MGI:MGI:1859499|PMID:10846166
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GRM1	IMP		Human	PMID:24603153
Biological Process	GO:0043410	positive regulation of MAPK cascade	Grm1	IDA		Mouse	MGI:MGI:1934687|PMID:11356865
Biological Process	GO:0051930	regulation of sensory perception of pain	Grm1	IDA		Mouse	MGI:MGI:1934687|PMID:11356865
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Grm1	IDA		Rat	PMID:11530226|RGD:8553469
Biological Process	GO:0019233	sensory perception of pain	Grm1	IMP		Mouse	MGI:MGI:1934687|PMID:11356865
Biological Process	GO:0019233	sensory perception of pain	Grm1	IEP		Rat	PMID:12514201|RGD:728822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern