Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Grm5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GRM5
- Mouse genes Grm5
- Rat genes Grm5
- Zfish genes grm5a,grm5b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031687	A2A adenosine receptor binding	Grm5	IPI	RGD:2049	Rat	PMID:12189203\|RGD:625594
Molecular Function	GO:0004930	G protein-coupled receptor activity	GRM5	IMP		Human	PMID:7908515
Molecular Function	GO:0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	Grm5	IMP		Mouse	MGI:MGI:3836821\|PMID:19169252
Molecular Function	GO:0008066	glutamate receptor activity	GRM5	IDA		Human	PMID:7908515
Molecular Function	GO:0008066	glutamate receptor activity	Grm5	IMP		Rat	PMID:1320017\|RGD:8553991
Molecular Function	GO:0042802	identical protein binding	GRM5	IPI	UniProtKB:P41594	Human	PMID:30675062
Molecular Function	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	Grm5	IMP		Mouse	MGI:MGI:5507793\|PMID:22586220
Molecular Function	GO:0005515	protein binding	GRM5	IPI	UniProtKB:P04156	Human	PMID:24012003
Molecular Function	GO:0005515	protein binding	GRM5	IPI	UniProtKB:Q9UQM7	Human	PMID:28130356
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P16056	Mouse	MGI:MGI:7258354\|PMID:27086544
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5515653\|PMID:24012003
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:Q13526\|UniProtKB:Q9Z214-1\|UniProtKB:Q9Z214-3\|UniProtKB:Q9Z214	Mouse	MGI:MGI:5506957\|PMID:23911326
Molecular Function	GO:0005515	protein binding	Grm5	IPI	PR:Q9Z2Y3	Mouse	PMID:12176012
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P29274	Rat	PMID:12189203\|RGD:625594
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P63088	Rat	PMID:14519764\|RGD:8553385
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:O88801	Rat	PMID:15758184\|RGD:8554618
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:Q9Z214	Rat	PMID:15758184\|RGD:8554618
Molecular Function	GO:0005515	protein binding	Grm5	IPI	RGD:628725	Rat	PMID:16554037\|RGD:1581788
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:Q8R4T5	Rat	PMID:17396155\|RGD:8553557
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:O35095	Rat	PMID:20007903\|RGD:8554035
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:Q13526	Rat	PMID:23911326\|RGD:8554446
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P04156:PRO_0000025675	Rat	PMID:24012003\|RGD:8553716
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P06241	Rat	PMID:24012003\|RGD:8553716
Molecular Function	GO:0005515	protein binding	Grm5	IPI	UniProtKB:P13852	Rat	PMID:24012003\|RGD:8553716
Molecular Function	GO:1990782	protein tyrosine kinase binding	Grm5	IPI	UniProtKB:Q62844	Rat	PMID:24012003\|RGD:8553716
Cellular Component	GO:0097449	astrocyte projection	Grm5	IDA		Rat	PMID:21753079\|RGD:7207797
Cellular Component	GO:0005737	cytoplasm	Grm5	IDA		Mouse	PMID:12176012
Cellular Component	GO:0043198	dendritic shaft	Grm5	IDA		Rat	PMID:18582438\|RGD:2303068
Cellular Component	GO:0043197	dendritic spine	Grm5	IDA		Rat	PMID:18582438\|RGD:2303068
Cellular Component	GO:0098978	glutamatergic synapse	Grm5	IDA		Rat	PMID:8758956\|RGD:13702390
Cellular Component	GO:0016020	membrane	Grm5	IDA		Rat	PMID:12189203\|RGD:625594
Cellular Component	GO:0043005	neuron projection	Grm5	IDA		Mouse	MGI:MGI:5320264\|PMID:21795692
Cellular Component	GO:0005886	plasma membrane	GRM5	IMP		Human	PMID:7908515
Cellular Component	GO:0005886	plasma membrane	Grm5	IDA		Mouse	PMID:12176012
Cellular Component	GO:0014069	postsynaptic density	Grm5	IDA		Rat	PMID:18582438\|RGD:2303068
Cellular Component	GO:0098839	postsynaptic density membrane	Grm5	IDA		Rat	PMID:9412905\|RGD:12859074
Cellular Component	GO:0045211	postsynaptic membrane	Grm5	IDA		Rat	PMID:8758956\|RGD:13702390
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Grm5	IDA		Mouse	PMID:11431513
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Grm5	IMP		Mouse	PMID:11431513
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	GRM5	IGI	UniProtKB:P04156	Human	PMID:24012003
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Grm5	IGI	UniProtKB:P04925	Mouse	MGI:MGI:5515653\|PMID:24012003
Biological Process	GO:1904646	cellular response to amyloid-beta	GRM5	IGI	UniProtKB:P04156	Human	PMID:24012003
Biological Process	GO:1904646	cellular response to amyloid-beta	Grm5	IGI	UniProtKB:P04925	Mouse	MGI:MGI:5515653\|PMID:24012003
Biological Process	GO:0007268	chemical synaptic transmission	Grm5	IMP		Rat	PMID:12514208\|RGD:728711
Biological Process	GO:0050890	cognition	GRM5	IMP		Human	PMID:23227193
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	Grm5	IDA		Rat	PMID:12514208\|RGD:728711
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	GRM5	IMP		Human	PMID:7908515
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	Grm5	IMP		Rat	PMID:1320017\|RGD:8553991
Biological Process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	Grm5	IMP		Rat	PMID:21993209\|RGD:12050103
Biological Process	GO:0007612	learning	Grm5	IMP	MGI:MGI:1857437	Mouse	PMID:9185557
Biological Process	GO:0007611	learning or memory	Grm5	IGI	UniProtKB:P12023,UniProtKB:P49769	Mouse	MGI:MGI:5515653\|PMID:24012003
Biological Process	GO:0007626	locomotory behavior	Grm5	IGI	MGI:MGI:94924	Mouse	PMID:16280580
Biological Process	GO:0007626	locomotory behavior	Grm5	IGI	MGI:MGI:99402	Mouse	PMID:16280580
Biological Process	GO:0007626	locomotory behavior	Grm5	IMP	MGI:MGI:1857437	Mouse	PMID:16280580
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Grm5	IDA		Mouse	PMID:11431513
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Grm5	IMP		Mouse	PMID:11431513
Biological Process	GO:0040013	negative regulation of locomotion	Grm5	IDA		Rat	PMID:12189203\|RGD:625594
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Grm5	IDA		Rat	PMID:12740378\|RGD:731147
Biological Process	GO:0043410	positive regulation of MAPK cascade	Grm5	IDA		Rat	PMID:15758184\|RGD:8554618
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Grm5	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5515653\|PMID:24012003
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Grm5	IGI	ComplexPortal:CPX-1134,UniProtKB:P13852	Rat	PMID:24012003\|RGD:8553716
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Grm5	IDA		Rat	PMID:12514208\|RGD:728711
Biological Process	GO:0006468	protein phosphorylation	Grm5	IDA		Rat	PMID:15758184\|RGD:8554618
Biological Process	GO:0006355	regulation of DNA-templated transcription	Grm5	IDA		Rat	PMID:12189203\|RGD:625594
Biological Process	GO:1902938	regulation of intracellular calcium activated chloride channel activity	GRM5	IGI	ComplexPortal:CPX-1134,UniProtKB:P04156	Human	PMID:24012003
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Grm5	IMP	MGI:MGI:1857437	Mouse	PMID:16024054
Biological Process	GO:0001932	regulation of protein phosphorylation	GRM5	IGI	ComplexPortal:CPX-1134	Human	PMID:24012003
Biological Process	GO:0006448	regulation of translational elongation	GRM5	IGI	UniProtKB:P06241,UniProtKB:P13639,UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0050808	synapse organization	Grm5	IGI	UniProtKB:P12023,UniProtKB:P49769	Mouse	MGI:MGI:5515653\|PMID:24012003
Biological Process	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	Grm5	IMP		Rat	PMID:21993209\|RGD:12050103

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.