Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRM7
  • Mouse genes Grm7
  • Rat genes Grm7
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grm7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	Grm7	IDA		Rat	PMID:11825890|RGD:728749
Molecular Function	GO:0010855	adenylate cyclase inhibitor activity	GRM7	IDA		Human	PMID:9473604
Molecular Function	GO:0005246	calcium channel regulator activity	Grm7	IDA		Mouse	PMID:11584003
Molecular Function	GO:0048306	calcium-dependent protein binding	Grm7	IPI	RGD:2257	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0048306	calcium-dependent protein binding	Grm7	IPI	RGD:620385	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0005516	calmodulin binding	Grm7	IPI	UniProtKB:P0DP29	Rat	PMID:12021391|RGD:8554716
Molecular Function	GO:0005516	calmodulin binding	Grm7	IPI	UniProtKB:P0DP30	Rat	PMID:12021391|RGD:8554716
Molecular Function	GO:0005516	calmodulin binding	Grm7	IPI	UniProtKB:P0DP31	Rat	PMID:12021391|RGD:8554716
Molecular Function	GO:0005516	calmodulin binding	Grm7	IPI	RGD:2257	Rat	PMID:21855531|RGD:7207139
Molecular Function	GO:0016595	glutamate binding	Grm7	IDA		Rat	PMID:11825890|RGD:728749
Molecular Function	GO:0016595	glutamate binding	Grm7	IDA		Rat	PMID:12692128|RGD:2289010
Molecular Function	GO:0016595	glutamate binding	Grm7	IDA		Rat	PMID:17620729|RGD:2289012
Molecular Function	GO:0008066	glutamate receptor activity	GRM7	IDA		Human	PMID:9473604
Molecular Function	GO:0001642	group III metabotropic glutamate receptor activity	GRM7	IDA		Human	PMID:9144652
Molecular Function	GO:0001642	group III metabotropic glutamate receptor activity	GRM7	IDA		Human	PMID:9473604
Molecular Function	GO:0001642	group III metabotropic glutamate receptor activity	Grm7	IDA		Rat	PMID:12692128|RGD:2289010
Molecular Function	GO:0042802	identical protein binding	Grm7	IPI	RGD:619857	Rat	PMID:17620729|RGD:2289012
Molecular Function	GO:0030165	PDZ domain binding	Grm7	IPI	RGD:69437	Rat	PMID:11007882|RGD:1643601
Molecular Function	GO:0005515	protein binding	Grm7	IPI	UniProtKB:P97879	Rat	PMID:11891216|RGD:8553442
Molecular Function	GO:0005515	protein binding	Grm7	IPI	UniProtKB:Q9EP80	Rat	PMID:11891216|RGD:8553442
Molecular Function	GO:0005515	protein binding	Grm7	IPI	UniProtKB:P63088	Rat	PMID:14519764|RGD:8553385
Molecular Function	GO:0046983	protein dimerization activity	GRM7	IMP		Human	PMID:33476302
Molecular Function	GO:0070905	serine binding	GRM7	IDA		Human	PMID:9144652
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Grm7	IDA		Mouse	MGI:MGI:3690146|PMID:12065412
Cellular Component	GO:0032279	asymmetric synapse	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0030424	axon	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0043679	axon terminus	Grm7	IDA		Rat	PMID:11825890|RGD:728749
Cellular Component	GO:0005938	cell cortex	GRM7	IDA		Human	PMID:9630572
Cellular Component	GO:0009986	cell surface	Grm7	IDA		Rat	PMID:16890965|RGD:8554329
Cellular Component	GO:0030425	dendrite	GRM7	IDA		Human	PMID:9630572
Cellular Component	GO:0030425	dendrite	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0043198	dendritic shaft	Grm7	IDA		Rat	PMID:12823458|RGD:2289008
Cellular Component	GO:0098982	GABA-ergic synapse	Grm7	IDA		Rat	PMID:12183395|RGD:728478
Cellular Component	GO:0098982	GABA-ergic synapse	Grm7	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0098978	glutamatergic synapse	Grm7	IDA		Mouse	PMID:12065412
Cellular Component	GO:0098978	glutamatergic synapse	Grm7	EXP		Mouse	PMID:12065412
Cellular Component	GO:0098978	glutamatergic synapse	Grm7	IDA		Rat	PMID:12183395|RGD:728478
Cellular Component	GO:0098978	glutamatergic synapse	Grm7	IDA		Rat	PMID:8604049|RGD:13702186
Cellular Component	GO:0098978	glutamatergic synapse	Grm7	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0005794	Golgi apparatus	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0016020	membrane	GRM7	IDA		Human	PMID:12746871
Cellular Component	GO:0016020	membrane	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0043025	neuronal cell body	Grm7	IDA		Rat	PMID:8929965|RGD:1643595
Cellular Component	GO:0043025	neuronal cell body	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0005886	plasma membrane	GRM7	IMP		Human	PMID:33500274
Cellular Component	GO:0045211	postsynaptic membrane	Grm7	IDA		Rat	PMID:8764662|RGD:8553461
Cellular Component	GO:0048786	presynaptic active zone	Grm7	IDA		Rat	PMID:12823458|RGD:2289008
Cellular Component	GO:0048786	presynaptic active zone	Grm7	IDA		Rat	PMID:8764662|RGD:8553461
Cellular Component	GO:0048786	presynaptic active zone	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm7	IDA		Rat	PMID:12183395|RGD:728478
Cellular Component	GO:0048787	presynaptic active zone membrane	Grm7	IDA		Rat	PMID:9295396|RGD:13702410
Cellular Component	GO:0042734	presynaptic membrane	Grm7	IDA		Mouse	MGI:MGI:3690146|PMID:12065412
Cellular Component	GO:0042734	presynaptic membrane	Grm7	IDA		Rat	PMID:8604049|RGD:13702186
Cellular Component	GO:0042734	presynaptic membrane	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0032991	protein-containing complex	Grm7	IDA		Rat	PMID:11007882|RGD:1643601
Cellular Component	GO:0043235	receptor complex	GRM7	IDA		Human	PMID:23382219
Cellular Component	GO:0005791	rough endoplasmic reticulum	Grm7	IDA		Rat	PMID:9300765|RGD:1643599
Cellular Component	GO:0045202	synapse	Grm7	IDA		Rat	PMID:11007882|RGD:1643601
Cellular Component	GO:0043195	terminal bouton	Grm7	IDA		Rat	PMID:12823458|RGD:2289008
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM7	IDA		Human	PMID:9473604
Biological Process	GO:0007196	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	Grm7	IDA		Rat	PMID:11825890|RGD:728749
Biological Process	GO:0030534	adult behavior	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:12814372
Biological Process	GO:0008306	associative learning	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:16775145
Biological Process	GO:0061564	axon development	GRM7	IMP		Human	PMID:33500274
Biological Process	GO:0001662	behavioral fear response	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:9920659
Biological Process	GO:0007268	chemical synaptic transmission	GRM7	IDA		Human	PMID:9473604
Biological Process	GO:0007268	chemical synaptic transmission	Grm7	IDA		Mouse	MGI:MGI:3690146|PMID:12065412
Biological Process	GO:0001661	conditioned taste aversion	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:9920659
Biological Process	GO:0070085	glycosylation	GRM7	IDA		Human	PMID:33500274
Biological Process	GO:0007613	memory	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:16204199
Biological Process	GO:0007613	memory	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:16775145
Biological Process	GO:0033555	multicellular organismal response to stress	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:12814372
Biological Process	GO:0014050	negative regulation of glutamate secretion	Grm7	IDA		Rat	PMID:11825890|RGD:728749
Biological Process	GO:0014050	negative regulation of glutamate secretion	Grm7	IDA		Rat	PMID:12692128|RGD:2289010
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Grm7	IDA		Rat	PMID:26621121|RGD:11537517
Biological Process	GO:0050877	nervous system process	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:16204199
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm7	EXP		Mouse	PMID:12065412
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grm7	IDA		Mouse	PMID:12065412
Biological Process	GO:0007605	sensory perception of sound	GRM7	IMP		Human	PMID:19047183
Biological Process	GO:0007614	short-term memory	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:15313036
Biological Process	GO:0019226	transmission of nerve impulse	Grm7	IMP	MGI:MGI:1857984	Mouse	PMID:11698585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern