Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GSC
  • Mouse genes Gsc
  • Rat genes Gsc
  • Zfish genes gsc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gsc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Gsc	IDA		Mouse	MGI:MGI:1101650|PMID:9417125
Molecular Function	GO:0005515	protein binding	Gsc	IPI	PR:O09106	Mouse	PMID:17568773
Molecular Function	GO:0005515	protein binding	Gsc	IPI	PR:Q6NZM9	Mouse	PMID:17568773
Molecular Function	GO:0005515	protein binding	Gsc	IPI	PR:O88621	Mouse	PMID:17568773
Molecular Function	GO:0005515	protein binding	Gsc	IPI	PR:Q91WA3	Mouse	PMID:17568773
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Gsc	IDA		Mouse	MGI:MGI:1101650|PMID:9417125
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Gsc	IPI	UniProtKB:P20293|UniProtKB:P70324|UniProtKB:P70327|UniProtKB:Q9ES03	Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	GSC	IDA		Human	PMID:28473536
Cellular Component	GO:0005667	transcription regulator complex	Gsc	IDA		Mouse	PMID:17568773
Biological Process	GO:0009653	anatomical structure morphogenesis	Gsc	IGI	MGI:MGI:1347476	Mouse	PMID:9226455
Biological Process	GO:0009948	anterior/posterior axis specification	gsc	IDA		Zfish	PMID:19369398
Biological Process	GO:0007420	brain development	gsc	IGI	ZFIN:ZDB-MRPHLNO-060321-1,ZFIN:ZDB-MRPHLNO-060321-4	Zfish	PMID:16364286
Biological Process	GO:0009950	dorsal/ventral axis specification	gsc	IEP		Zfish	PMID:8104775
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Gsc	IGI	MGI:MGI:1347476	Mouse	PMID:9226455
Biological Process	GO:0009953	dorsal/ventral pattern formation	gsc	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-060321-1	Zfish	PMID:19369398
Biological Process	GO:0009953	dorsal/ventral pattern formation	gsc	IGI	ZFIN:ZDB-GENO-070516-1,ZFIN:ZDB-MRPHLNO-060321-1	Zfish	PMID:19369398
Biological Process	GO:0009953	dorsal/ventral pattern formation	gsc	IDA		Zfish	PMID:19369398
Biological Process	GO:0043583	ear development	Gsc	IMP	MGI:MGI:1857496	Mouse	PMID:7555718
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Gsc	IMP	MGI:MGI:1857496	Mouse	PMID:7555718
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Gsc	IMP	MGI:MGI:1857726	Mouse	PMID:7555726
Biological Process	GO:0030900	forebrain development	Gsc	IGI	MGI:MGI:1329040	Mouse	PMID:17127040
Biological Process	GO:0042474	middle ear morphogenesis	Gsc	IMP		Mouse	MGI:MGI:3035838|PMID:14973294
Biological Process	GO:0048644	muscle organ morphogenesis	Gsc	IMP	MGI:MGI:1857496	Mouse	PMID:7555718
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Gsc	IDA		Mouse	MGI:MGI:1101650|PMID:9417125
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Gsc	IGI	MGI:MGI:1347465	Mouse	PMID:17568773
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Gsc	IMP	MGI:MGI:1857726	Mouse	PMID:17127040
Biological Process	GO:0014036	neural crest cell fate specification	GSC	IMP		Human	PMID:24290375
Biological Process	GO:0021999	neural plate anterior/posterior regionalization	gsc	IGI	ZFIN:ZDB-MRPHLNO-060321-1,ZFIN:ZDB-MRPHLNO-060321-4	Zfish	PMID:16364286
Biological Process	GO:0060234	neuroblast delamination	gsc	IMP	ZFIN:ZDB-GENO-170127-2	Zfish	PMID:27791112
Biological Process	GO:0071599	otic vesicle development	gsc	IMP	ZFIN:ZDB-GENO-170127-2	Zfish	PMID:27791112
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	gsc	IMP	ZFIN:ZDB-GENO-170127-2	Zfish	PMID:27791112
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Gsc	IDA		Mouse	PMID:18462699
Biological Process	GO:0016055	Wnt signaling pathway	Gsc	IMP	MGI:MGI:1857726	Mouse	PMID:17127040

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern