Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GSDMD
  • Mouse genes Gsdmd
  • Rat genes Gsdmd
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gsdmd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1901612	cardiolipin binding	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Molecular Function	GO:0099103	channel activator activity	Gsdmd	IDA		Mouse	PMID:27383986
Molecular Function	GO:0070300	phosphatidic acid binding	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GSDMD	IDA		Human	PMID:27281216
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GSDMD	IDA		Human	PMID:36227980
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Gsdmd	IDA		Mouse	PMID:27383986
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	GSDMD	IDA		Human	PMID:36227980
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Molecular Function	GO:0001786	phosphatidylserine binding	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q8NC69	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q8NC69	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:P25786	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q86T24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q86U10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q8NC69	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q96NG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:Q9BUY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:P0DTC9	Human	PMID:34296442
Molecular Function	GO:0005515	protein binding	GSDMD	IPI	UniProtKB:P29466	Human	PMID:34296442
Molecular Function	GO:0022829	wide pore channel activity	GSDMD	IDA		Human	PMID:32109412
Molecular Function	GO:0022829	wide pore channel activity	GSDMD	IDA		Human	PMID:33883744
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	MGI:MGI:6151369|PMID:29274245
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	MGI:MGI:6867106|PMID:33883744
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	MGI:MGI:6141670|PMID:29195811
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	MGI:MGI:6467712|PMID:32820063
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	PMID:35705808
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	PMID:27339137
Molecular Function	GO:0022829	wide pore channel activity	Gsdmd	IDA		Mouse	PMID:27383986
Cellular Component	GO:0005829	cytosol	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Cellular Component	GO:0005615	extracellular space	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Cellular Component	GO:0016020	membrane	GSDMD	IDA		Human	PMID:32109412
Cellular Component	GO:0016020	membrane	GSDMD	IDA		Human	PMID:33883744
Cellular Component	GO:0072559	NLRP3 inflammasome complex	Gsdmd	IDA		Mouse	MGI:MGI:5751630|PMID:26611636
Cellular Component	GO:0005654	nucleoplasm	GSDMD	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	GSDMD	IDA		Human	PMID:32109412
Cellular Component	GO:0005886	plasma membrane	GSDMD	IDA		Human	PMID:33883744
Cellular Component	GO:0005886	plasma membrane	GSDMD	IDA		Human	PMID:36227980
Cellular Component	GO:0005886	plasma membrane	Gsdmd	IDA		Mouse	PMID:35705808
Cellular Component	GO:0005886	plasma membrane	Gsdmd	IDA		Mouse	PMID:27383986
Cellular Component	GO:0005886	plasma membrane	Gsdmd	IDA		Mouse	PMID:27339137
Biological Process	GO:0031668	cellular response to extracellular stimulus	Gsdmd	IDA		Mouse	PMID:10322635
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Biological Process	GO:0046931	pore complex assembly	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Biological Process	GO:0050729	positive regulation of inflammatory response	GSDMD	IDA		Human	PMID:32109412
Biological Process	GO:0050729	positive regulation of inflammatory response	GSDMD	IDA		Human	PMID:33883744
Biological Process	GO:0050729	positive regulation of inflammatory response	Gsdmd	IDA		Mouse	PMID:27383986
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Gsdmd	IDA		Mouse	MGI:MGI:6141670|PMID:29195811
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Gsdmd	IDA		Mouse	MGI:MGI:6867106|PMID:33883744
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Gsdmd	IDA		Mouse	MGI:MGI:5751630|PMID:26611636
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Gsdmd	IDA		Mouse	MGI:MGI:6151369|PMID:29274245
Biological Process	GO:0051260	protein homooligomerization	Gsdmd	IDA		Mouse	MGI:MGI:5796057|PMID:27383986
Biological Process	GO:0009306	protein secretion	GSDMD	IDA		Human	PMID:33883744
Biological Process	GO:0009306	protein secretion	Gsdmd	IDA		Mouse	PMID:35705808
Biological Process	GO:0070269	pyroptosis	GSDMD	IDA		Human	PMID:32109412
Biological Process	GO:0070269	pyroptosis	GSDMD	IDA		Human	PMID:33883744
Biological Process	GO:0070269	pyroptosis	GSDMD	IDA		Human	PMID:36227980
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	MGI:MGI:6467703|PMID:32109412
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	MGI:MGI:5751630|PMID:26611636
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	MGI:MGI:6467707|PMID:32553275
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	MGI:MGI:6467699|PMID:29576317
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	MGI:MGI:6467712|PMID:32820063
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	PMID:35705808
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	PMID:27383986
Biological Process	GO:0070269	pyroptosis	Gsdmd	IDA		Mouse	PMID:27339137

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern