Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GSDME
  • Mouse genes Gsdme
  • Rat genes Gsdme
  • Zfish genes gsdmea,gsdmeb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gsdme

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1901612	cardiolipin binding	GSDME	IDA		Human	PMID:28459430
Molecular Function	GO:1901612	cardiolipin binding	Gsdme	IDA		Mouse	MGI:MGI:6103259|PMID:28459430
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GSDME	IDA		Human	PMID:28459430
Molecular Function	GO:0005515	protein binding	GSDME	IPI	UniProtKB:Q96CG3	Human	PMID:32296183
Molecular Function	GO:0022829	wide pore channel activity	GSDME	IDA		Human	PMID:28459430
Molecular Function	GO:0022829	wide pore channel activity	GSDME	IDA		Human	PMID:32188940
Molecular Function	GO:0022829	wide pore channel activity	GSDME	IDA		Human	PMID:33852854
Molecular Function	GO:0022829	wide pore channel activity	GSDME	IDA		Human	PMID:35594856
Cellular Component	GO:0005737	cytoplasm	Gsdme	IDA		Mouse	PMID:28209736
Cellular Component	GO:0005829	cytosol	GSDME	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	GSDME	IDA		Human	PMID:28459430
Cellular Component	GO:0016020	membrane	GSDME	IDA		Human	PMID:28045099
Cellular Component	GO:0005886	plasma membrane	GSDME	IDA		Human	PMID:28459430
Biological Process	GO:0008219	cell death	GSDME	IMP		Human	PMID:26236191
Biological Process	GO:0071356	cellular response to tumor necrosis factor	GSDME	IDA		Human	PMID:28459430
Biological Process	GO:0098586	cellular response to virus	GSDME	IDA		Human	PMID:28045099
Biological Process	GO:0098586	cellular response to virus	Gsdme	IMP		Mouse	MGI:MGI:5901785|PMID:28045099
Biological Process	GO:0042471	ear morphogenesis	gsdmeb	IMP		Zfish	PMID:14736743
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	Gsdme	IMP	MGI:MGI:3583715	Mouse	PMID:16023581
Biological Process	GO:0042472	inner ear morphogenesis	gsdmeb	IMP		Zfish	PMID:14736743
Biological Process	GO:0070265	necrotic cell death	GSDME	IDA		Human	PMID:28045099
Biological Process	GO:0070265	necrotic cell death	Gsdme	IMP		Mouse	MGI:MGI:5901785|PMID:28045099
Biological Process	GO:0008285	negative regulation of cell population proliferation	GSDME	IDA		Human	PMID:18223688
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	GSDME	IDA		Human	PMID:32188940
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GSDME	IDA		Human	PMID:21522185
Biological Process	GO:0043410	positive regulation of MAPK cascade	GSDME	IMP		Human	PMID:26236191
Biological Process	GO:0070269	pyroptosis	GSDME	IDA		Human	PMID:28459430
Biological Process	GO:0070269	pyroptosis	GSDME	IDA		Human	PMID:32188940
Biological Process	GO:0070269	pyroptosis	GSDME	IDA		Human	PMID:33852854
Biological Process	GO:0070269	pyroptosis	GSDME	IDA		Human	PMID:35594856
Biological Process	GO:0070269	pyroptosis	gsdmeb	IDA		Zfish	PMID:31852739
Biological Process	GO:0070269	pyroptosis	gsdmea	IDA		Zfish	PMID:31852739
Biological Process	GO:0070269	pyroptosis	gsdmeb	IMP	ZFIN:ZDB-GENO-210406-12	Zfish	PMID:32111733
Biological Process	GO:0070269	pyroptosis	gsdmeb	IGI	ZFIN:ZDB-GENO-210602-8	Zfish	PMID:32332700
Biological Process	GO:0009889	regulation of biosynthetic process	gsdmeb	IMP		Zfish	PMID:14736743

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern