Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Gsk3a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes GSK3A
- Mouse genes Gsk3a
- Rat genes Gsk3a
- Zfish genes gsk3aa,gsk3ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gsk3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q92837	Human	PMID:10481074
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O75581	Human	PMID:16365045
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O15169	Human	PMID:17318175
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O15169	Human	PMID:17510365
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O00571\|UniProtKB:O14763	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q9UQB3	Human	PMID:19706605
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O75398	Human	PMID:20368287
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q14596	Human	PMID:20368287
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O15169	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q92837	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q8IUH5	Human	PMID:24705354
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q14596	Human	PMID:24879152
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q6R327	Human	PMID:25897075
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q92837	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:26618561
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O75398	Human	PMID:30824926
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:O75581	Human	PMID:30824926
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:P08238	Human	PMID:30824926
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q14596	Human	PMID:30824926
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:Q6UX01	Human	PMID:31073040
Molecular Function	GO:0005515	protein binding	GSK3A	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Gsk3a	IPI	UniProtKB:P29067	Mouse	MGI:MGI:3690676\|PMID:16051150
Molecular Function	GO:0005515	protein binding	Gsk3a	IPI	UniProtKB:O54918	Mouse	MGI:MGI:4818524\|PMID:20371704
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	GSK3A	IPI	UniProtKB:P17612	Human	PMID:11035810
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	Gsk3a	IPI	UniProtKB:P27791	Rat	PMID:11035810\|RGD:8554447
Molecular Function	GO:0004672	protein kinase activity	Gsk3a	IDA		Mouse	MGI:MGI:5319706\|PMID:22539723
Molecular Function	GO:0004672	protein kinase activity	Gsk3a	IDA		Mouse	PMID:14730361
Molecular Function	GO:0019901	protein kinase binding	Gsk3a	IPI	RGD:2262	Rat	PMID:20841359\|RGD:10401822
Molecular Function	GO:0004674	protein serine/threonine kinase activity	GSK3A	IDA		Human	PMID:11035810
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Gsk3a	IMP		Mouse	MGI:MGI:5514334\|PMID:16543145
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Gsk3a	IDA		Mouse	PMID:17986005
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Gsk3a	IDA		Rat	PMID:11035810\|RGD:8554447
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Gsk3a	IDA		Rat	PMID:2164470\|RGD:70757
Molecular Function	GO:0120283	protein serine/threonine kinase binding	Gsk3a	IPI	UniProtKB:P47196	Rat	PMID:8524413\|RGD:8554844
Molecular Function	GO:0005102	signaling receptor binding	GSK3A	IPI	UniProtKB:P04150	Human	PMID:20371704
Molecular Function	GO:0005102	signaling receptor binding	Gsk3a	IPI	UniProtKB:P06537	Mouse	MGI:MGI:4818524\|PMID:20371704
Cellular Component	GO:0005737	cytoplasm	Gsk3a	IDA		Rat	PMID:8576078\|RGD:10401922
Cellular Component	GO:0005874	microtubule	Gsk3a	IDA		Rat	PMID:8576078\|RGD:10401922
Biological Process	GO:0007568	aging	Gsk3a	IDA		Rat	PMID:18782348\|RGD:10401821
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:0055013	cardiac muscle cell development	gsk3ab	IMP	ZFIN:ZDB-MRPHLNO-071220-1	Zfish	PMID:17683539
Biological Process	GO:0016477	cell migration	Gsk3a	IGI	MGI:MGI:98958	Mouse	PMID:17986005
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Gsk3a	IGI	UniProtKB:Q9WV60	Mouse	MGI:MGI:4818524\|PMID:20371704
Biological Process	GO:0032869	cellular response to insulin stimulus	GSK3A	IMP		Human	PMID:17569761
Biological Process	GO:0036016	cellular response to interleukin-3	Gsk3a	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0071285	cellular response to lithium ion	Gsk3a	IDA		Mouse	PMID:15673614
Biological Process	GO:0071407	cellular response to organic cyclic compound	Gsk3a	IDA		Mouse	PMID:12055200
Biological Process	GO:0009953	dorsal/ventral pattern formation	gsk3ab	IGI	ZFIN:ZDB-GENE-000403-1	Zfish	PMID:10704853
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Gsk3a	IGI	UniProtKB:Q9WV60	Mouse	MGI:MGI:4818524\|PMID:20371704
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Gsk3a	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0001947	heart looping	gsk3ab	IMP	ZFIN:ZDB-MRPHLNO-071220-1	Zfish	PMID:17683539
Biological Process	GO:0008286	insulin receptor signaling pathway	Gsk3a	IDA		Mouse	MGI:MGI:3836105\|PMID:18285345
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:2000171	negative regulation of dendrite development	Gsk3a	IMP		Rat	PMID:23470087\|RGD:10401820
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Gsk3a	IMP		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0046325	negative regulation of glucose import	GSK3A	IMP		Human	PMID:17569761
Biological Process	GO:1904227	negative regulation of glycogen synthase activity, transferring glucose-1-phosphate	GSK3A	IMP		Human	PMID:17569761
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	GSK3A	IMP		Human	PMID:17569761
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Gsk3a	IDA		Rat	PMID:8524413\|RGD:8554844
Biological Process	GO:0032007	negative regulation of TOR signaling	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Gsk3a	IGI	UniProtKB:Q9WV60	Mouse	MGI:MGI:6094357\|PMID:16537926
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Gsk3a	IDA		Mouse	PMID:17986005
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	GSK3A	IDA		Human	PMID:25897075
Biological Process	GO:0071879	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	GSK3A	IGI	UniProtKB:P49841	Human	PMID:12761548
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	GSK3A	IMP		Human	PMID:12761548
Biological Process	GO:0010508	positive regulation of autophagy	Gsk3a	IDA		Mouse	MGI:MGI:5319706\|PMID:22539723
Biological Process	GO:0010628	positive regulation of gene expression	Gsk3a	IGI	UniProtKB:Q9WV60	Mouse	MGI:MGI:4818524\|PMID:20371704
Biological Process	GO:2000467	positive regulation of glycogen (starch) synthase activity	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:0045823	positive regulation of heart contraction	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Gsk3a	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Gsk3a	IMP		Rat	PMID:20841359\|RGD:10401822
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Gsk3a	IDA		Mouse	PMID:17986005
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Gsk3a	IDA		Mouse	PMID:17986005
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GSK3A	IMP		Human	PMID:25897075
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	GSK3A	IMP		Human	PMID:24912190
Biological Process	GO:0031398	positive regulation of protein ubiquitination	GSK3A	IMP		Human	PMID:25897075
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Gsk3a	IMP		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Gsk3a	IDA		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0006468	protein phosphorylation	GSK3A	IDA		Human	PMID:11035810
Biological Process	GO:0006468	protein phosphorylation	Gsk3a	IMP		Mouse	MGI:MGI:5514334\|PMID:16543145
Biological Process	GO:0006468	protein phosphorylation	Gsk3a	IDA		Mouse	PMID:14730361
Biological Process	GO:0006468	protein phosphorylation	Gsk3a	IDA		Rat	PMID:11035810\|RGD:8554447
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	GSK3A	IMP		Human	PMID:24912190
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Gsk3a	IMP		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0003073	regulation of systemic arterial blood pressure	Gsk3a	IMP		Mouse	MGI:MGI:4829580\|PMID:20516643

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.