Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GTPBP4
  • Mouse genes Gtpbp4
  • Rat genes Gtpbp4
  • Zfish genes gtpbp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gtpbp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	GTPBP4	IDA		Human	PMID:17210637
Molecular Function	GO:0003924	GTPase activity	GTPBP4	IDA		Human	PMID:17210637
Molecular Function	GO:1990275	preribosome binding	GTPBP4	IDA		Human	PMID:32669547
Molecular Function	GO:0005515	protein binding	GTPBP4	IPI	UniProtKB:P35240	Human	PMID:17210637
Molecular Function	GO:0005515	protein binding	GTPBP4	IPI	UniProtKB:P53618	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GTPBP4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	GTPBP4	IPI	UniProtKB:P0DW28	Human	PMID:35393574
Molecular Function	GO:0003723	RNA binding	GTPBP4	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	GTPBP4	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	GTPBP4	IDA		Human	PMID:17210637
Cellular Component	GO:0005829	cytosol	GTPBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	GTPBP4	HDA		Human	PMID:16210410
Cellular Component	GO:0016020	membrane	GTPBP4	HDA		Human	PMID:19946888
Cellular Component	GO:0031965	nuclear membrane	GTPBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	GTPBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	GTPBP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	GTPBP4	IDA		Human	PMID:17210637
Cellular Component	GO:0005634	nucleus	GTPBP4	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Gtpbp4	IDA		Rat	PMID:11316846|RGD:632611
Cellular Component	GO:0048471	perinuclear region of cytoplasm	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Gtpbp4	IMP		Mouse	PMID:25190460
Biological Process	GO:0030336	negative regulation of cell migration	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0008285	negative regulation of cell population proliferation	GTPBP4	IMP		Human	PMID:17210637
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0033342	negative regulation of collagen binding	GTPBP4	IMP		Human	PMID:17210637
Biological Process	GO:0008156	negative regulation of DNA replication	GTPBP4	IMP		Human	PMID:17210637
Biological Process	GO:0031397	negative regulation of protein ubiquitination	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0001649	osteoblast differentiation	GTPBP4	HDA		Human	PMID:16210410
Biological Process	GO:0050821	protein stabilization	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	GTPBP4	IDA		Human	PMID:17210637
Biological Process	GO:0042273	ribosomal large subunit biogenesis	GTPBP4	IDA		Human	PMID:32669547

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern