Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GUCA1A
  • Mouse genes Guca1a
  • Rat genes Guca1a
  • Zfish genes guca1a,guca1e,si:ch211-103a14.5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Guca1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	guca1a	IDA		Zfish	PMID:26061947
Molecular Function	GO:0005509	calcium ion binding	guca1a	IDA		Zfish	PMID:21829700
Molecular Function	GO:0005509	calcium ion binding	guca1e	IDA		Zfish	PMID:21829700
Molecular Function	GO:0005509	calcium ion binding	guca1e	IDA		Zfish	PMID:26061947
Molecular Function	GO:0008048	calcium sensitive guanylate cyclase activator activity	Guca1a	IDA		Mouse	PMID:11493703
Molecular Function	GO:0008048	calcium sensitive guanylate cyclase activator activity	guca1a	IDA		Zfish	PMID:21829700
Molecular Function	GO:0008048	calcium sensitive guanylate cyclase activator activity	guca1e	IDA		Zfish	PMID:23940527
Molecular Function	GO:0008048	calcium sensitive guanylate cyclase activator activity	guca1e	IDA		Zfish	PMID:21829700
Molecular Function	GO:0008198	ferrous iron binding	guca1e	IDA		Zfish	PMID:29172459
Molecular Function	GO:0030249	guanylate cyclase regulator activity	GUCA1A	IMP		Human	PMID:30622141
Molecular Function	GO:0030249	guanylate cyclase regulator activity	Guca1a	IGI	MGI:MGI:1194489	Mouse	PMID:15336959
Molecular Function	GO:0042802	identical protein binding	guca1e	IPI	ZFIN:ZDB-GENE-040426-1577	Zfish	PMID:29172459
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:P31321	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:Q96PH6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:Q9BW62	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	GUCA1A	IPI	UniProtKB:Q9BXJ0	Human	PMID:32296183
Cellular Component	GO:0120199	cone photoreceptor outer segment	GUCA1A	IDA		Human	PMID:9620085
Cellular Component	GO:0120199	cone photoreceptor outer segment	Guca1a	IDA		Mouse	MGI:MGI:6437034|PMID:9620085
Cellular Component	GO:0016020	membrane	Guca1a	IDA		Rat	PMID:11294632|RGD:1599356
Cellular Component	GO:0001917	photoreceptor inner segment	GUCA1A	IDA		Human	PMID:9620085
Cellular Component	GO:0001917	photoreceptor inner segment	Guca1a	IDA		Mouse	MGI:MGI:6437034|PMID:9620085
Cellular Component	GO:0001917	photoreceptor inner segment	Guca1a	IDA		Rat	PMID:9620085|RGD:1599354
Cellular Component	GO:0001750	photoreceptor outer segment	Guca1a	IDA		Mouse	PMID:22183407
Cellular Component	GO:0001750	photoreceptor outer segment	Guca1a	IDA		Rat	PMID:9620085|RGD:1599354
Biological Process	GO:0007602	phototransduction	Guca1a	IMP	MGI:MGI:2664159	Mouse	PMID:15173221
Biological Process	GO:0007602	phototransduction	Guca1a	IMP	MGI:MGI:2664159	Mouse	PMID:11493703
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Guca1a	IDA		Rat	PMID:12545196|RGD:1599357
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	Guca1a	IDA		Rat	PMID:12545196|RGD:1599357
Biological Process	GO:0031282	regulation of guanylate cyclase activity	Guca1a	IGI	MGI:MGI:1194489	Mouse	PMID:15336959
Biological Process	GO:0007601	visual perception	Guca1a	IMP	MGI:MGI:2664159	Mouse	PMID:15173221
Biological Process	GO:0007601	visual perception	Guca1a	IMP	MGI:MGI:2664159	Mouse	PMID:11493703

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern