Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GUCY1A1
  • Mouse genes Gucy1a1
  • Rat genes Gucy1a1
  • Zfish genes gucy1a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gucy1a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	Gucy1a1	IDA		Rat	PMID:22122229|RGD:10401947
Molecular Function	GO:0047805	cytidylate cyclase activity	Gucy1a1	IDA		Rat	PMID:22122229|RGD:10401947
Molecular Function	GO:0004383	guanylate cyclase activity	GUCY1A1	IDA		Human	PMID:23505436
Molecular Function	GO:0043167	ion binding	Gucy1a1	IDA		Rat	PMID:17098738|RGD:1641948
Molecular Function	GO:0005515	protein binding	GUCY1A1	IPI	UniProtKB:Q02153	Human	PMID:23505436
Molecular Function	GO:0044877	protein-containing complex binding	Gucy1a1	IDA		Rat	PMID:17098738|RGD:1641948
Cellular Component	GO:0098982	GABA-ergic synapse	Gucy1a1	IDA		Mouse	PMID:28782641
Cellular Component	GO:0098982	GABA-ergic synapse	Gucy1a1	IMP		Mouse	PMID:28782641
Cellular Component	GO:0098978	glutamatergic synapse	Gucy1a1	IDA		Mouse	PMID:28782641
Cellular Component	GO:0098978	glutamatergic synapse	Gucy1a1	IMP		Mouse	PMID:28782641
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	GUCY1A1	IPI		Human	PMID:23505436
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	GUCY1A1	IDA		Human	PMID:23505436
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	Gucy1a1	IDA		Rat	PMID:17098738|RGD:1641948
Cellular Component	GO:0032991	protein-containing complex	Gucy1a1	IDA		Rat	PMID:16024662|RGD:1641952
Cellular Component	GO:0045202	synapse	Gucy1a1	IDA		Mouse	MGI:MGI:6092877|PMID:28782641
Biological Process	GO:0006182	cGMP biosynthetic process	GUCY1A1	IDA		Human	PMID:23505436
Biological Process	GO:0006182	cGMP biosynthetic process	Gucy1a1	IMP	MGI:MGI:3640802	Mouse	PMID:16614755
Biological Process	GO:0090594	inflammatory response to wounding	gucy1a1	IMP	ZFIN:ZDB-MRPHLNO-160120-2	Zfish	PMID:26444552
Biological Process	GO:0007263	nitric oxide mediated signal transduction	Gucy1a1	IMP	MGI:MGI:3640802	Mouse	PMID:16614755
Biological Process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway	GUCY1A1	IDA		Human	PMID:23505436
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	Gucy1a1	IMP	MGI:MGI:3640802	Mouse	PMID:16614755
Biological Process	GO:0008217	regulation of blood pressure	Gucy1a1	IMP	MGI:MGI:3640802	Mouse	PMID:16614755
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	Gucy1a1	IMP	MGI:MGI:3640802	Mouse	PMID:16614755
Biological Process	GO:0009635	response to herbicide	Gucy1a1	IEP		Rat	PMID:20388547|RGD:2317876
Biological Process	GO:0014070	response to organic cyclic compound	Gucy1a1	IEP		Rat	PMID:19025659|RGD:2312804
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	Gucy1a1	IMP		Mouse	PMID:28782641
Biological Process	GO:0098925	retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	Gucy1a1	IDA		Mouse	PMID:28782641

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern