Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GUCY1B1
  • Mouse genes Gucy1b1
  • Rat genes Gucy1b1
  • Zfish genes gucy1b1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gucy1b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	Gucy1b1	IDA		Rat	PMID:22122229|RGD:10401947
Molecular Function	GO:0047805	cytidylate cyclase activity	Gucy1b1	IDA		Rat	PMID:22122229|RGD:10401947
Molecular Function	GO:0004383	guanylate cyclase activity	GUCY1B1	IDA		Human	PMID:23505436
Molecular Function	GO:0020037	heme binding	Gucy1b1	IDA		Rat	PMID:11688978|RGD:1298936
Molecular Function	GO:0051879	Hsp90 protein binding	Gucy1b1	IDA		Rat	PMID:16024662|RGD:1641952
Molecular Function	GO:0043167	ion binding	Gucy1b1	IDA		Rat	PMID:17098738|RGD:1641948
Molecular Function	GO:0005515	protein binding	GUCY1B1	IPI	UniProtKB:Q02108	Human	PMID:23505436
Molecular Function	GO:0005515	protein binding	Gucy1b1	IPI	UniProtKB:P31016	Rat	PMID:11572861|RGD:70590
Molecular Function	GO:0044877	protein-containing complex binding	Gucy1b1	IDA		Rat	PMID:17098738|RGD:1641948
Cellular Component	GO:0098978	glutamatergic synapse	Gucy1b1	IDA		Rat	PMID:12388603|RGD:12050093
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	GUCY1B1	IPI		Human	PMID:23505436
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	GUCY1B1	IDA		Human	PMID:23505436
Cellular Component	GO:0008074	guanylate cyclase complex, soluble	Gucy1b1	IDA		Rat	PMID:17098738|RGD:1641948
Cellular Component	GO:0048786	presynaptic active zone	Gucy1b1	IDA		Rat	PMID:12388603|RGD:12050093
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Gucy1b1	IDA		Rat	PMID:12388603|RGD:12050093
Cellular Component	GO:0032991	protein-containing complex	Gucy1b1	IDA		Rat	PMID:16024662|RGD:1641952
Biological Process	GO:0006182	cGMP biosynthetic process	GUCY1B1	IDA		Human	PMID:23505436
Biological Process	GO:0019934	cGMP-mediated signaling	Gucy1b1	IMP		Mouse	MGI:MGI:5609454|PMID:25413364
Biological Process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway	GUCY1B1	IDA		Human	PMID:23505436
Biological Process	GO:0099555	trans-synaptic signaling by nitric oxide, modulating synaptic transmission	Gucy1b1	IMP		Mouse	MGI:MGI:5609454|PMID:25413364

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern