Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GUCY2D
  • Mouse genes Gucy2e
  • Rat genes Gucy2d
  • Zfish genes gucy2d
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gucy2e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004383	guanylate cyclase activity	GUCY2D	IDA		Human	PMID:21928830
Molecular Function	GO:0004383	guanylate cyclase activity	GUCY2D	IDA		Human	PMID:30319355
Molecular Function	GO:0004383	guanylate cyclase activity	Gucy2e	IDA		Mouse	MGI:MGI:5049799|PMID:21598940
Molecular Function	GO:0004383	guanylate cyclase activity	Gucy2d	IDA		Rat	PMID:7831337|RGD:632891
Molecular Function	GO:0042802	identical protein binding	Gucy2d	IPI	RGD:620438	Rat	PMID:9153227|RGD:1599625
Molecular Function	GO:0005515	protein binding	GUCY2D	IPI	UniProtKB:Q7Z3Z2	Human	PMID:21078983
Molecular Function	GO:0005515	protein binding	GUCY2D	IPI	UniProtKB:Q3TPE9	Human	PMID:21124868
Molecular Function	GO:0042803	protein homodimerization activity	Gucy2d	IDA		Rat	PMID:9153227|RGD:1599625
Molecular Function	GO:0044877	protein-containing complex binding	Gucy2d	IPI	RGD:620439	Rat	PMID:9153227|RGD:1599625
Cellular Component	GO:0005789	endoplasmic reticulum membrane	GUCY2D	IDA		Human	PMID:30319355
Cellular Component	GO:0001750	photoreceptor outer segment	GUCY2D	IDA		Human	PMID:7912093
Cellular Component	GO:0042622	photoreceptor outer segment membrane	Gucy2e	IDA		Mouse	MGI:MGI:5049799|PMID:21598940
Cellular Component	GO:0042622	photoreceptor outer segment membrane	Gucy2d	IDA		Rat	PMID:9153227|RGD:1599625
Cellular Component	GO:0005886	plasma membrane	Gucy2d	IDA		Rat	PMID:9153227|RGD:1599625
Biological Process	GO:0006182	cGMP biosynthetic process	Gucy2e	IDA		Mouse	MGI:MGI:5049799|PMID:21598940
Biological Process	GO:0019934	cGMP-mediated signaling	Gucy2d	IDA		Rat	PMID:9153227|RGD:1599625

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern