Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GZMB,GZMH
  • Mouse genes Gzme
  • Rat genes Gzmf,Gzmn
  • Zfish genes gzm3,gzm3.2,gzm3.3,gzm3.4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Gzme

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0099103	channel activator activity	GZMB	IDA		Human	PMID:31953257
Molecular Function	GO:0099103	channel activator activity	GZMB	IDA		Human	PMID:32188940
Molecular Function	GO:0005515	protein binding	GZMB	IPI	UniProtKB:P10124	Human	PMID:11911826
Molecular Function	GO:0005515	protein binding	GZMB	IPI	UniProtKB:P14222	Human	PMID:11911826
Molecular Function	GO:0005515	protein binding	GZMB	IPI	UniProtKB:P50453	Human	PMID:16267761
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	IDA		Human	PMID:11331782
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	IDA		Human	PMID:20038786
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	IDA		Human	PMID:31953257
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	EXP		Human	PMID:32188940
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	IDA		Human	PMID:32188940
Molecular Function	GO:0004252	serine-type endopeptidase activity	GZMB	IDA		Human	PMID:9852092
Cellular Component	GO:0044194	cytolytic granule	GZMB	IDA		Human	PMID:24088571
Cellular Component	GO:0005737	cytoplasm	GZMB	IDA		Human	PMID:20038786
Cellular Component	GO:0016020	membrane	GZMB	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	GZMH	HDA		Human	PMID:19946888
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMB	IDA		Human	PMID:20038786
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMB	IDA		Human	PMID:31953257
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMB	IDA		Human	PMID:32188940
Biological Process	GO:0140507	granzyme-mediated programmed cell death signaling pathway	GZMB	IDA		Human	PMID:9852092
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	GZMB	IMP		Human	PMID:21795594
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	GZMB	IDA		Human	PMID:32188940
Biological Process	GO:0017148	negative regulation of translation	GZMB	IDA		Human	PMID:29107333
Biological Process	GO:0051604	protein maturation	GZMB	IDA		Human	PMID:31953257
Biological Process	GO:0051604	protein maturation	GZMB	IDA		Human	PMID:32188940
Biological Process	GO:0051604	protein maturation	GZMB	IDA		Human	PMID:9852092
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	GZMB	IDA		Human	PMID:31953257
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	GZMB	IDA		Human	PMID:32188940
Biological Process	GO:0070269	pyroptosis	GZMB	IDA		Human	PMID:32188940

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern