Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes H1-4
  • Mouse genes H1f4
  • Rat genes H1f4
  • Zfish genes h1l1,histh1l2,si:ch211-113a14.18,si:ch211-113a14.24,si:dkey-108k21.10,si:dkey-23a13.9,si:dkey-261m9.12,zgc:110216,zgc:153405
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H1f4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0016208	AMP binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0005524	ATP binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0005509	calcium ion binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0031490	chromatin DNA binding	H1-4	IMP		Human	PMID:15911621
Molecular Function	GO:0032564	dATP binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0003677	DNA binding	H1f4	IDA		Mouse	PMID:15562002
Molecular Function	GO:0003677	DNA binding	H1f4	EXP		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0003690	double-stranded DNA binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0005525	GTP binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0000166	nucleotide binding	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Molecular Function	GO:0005515	protein binding	H1-4	IPI	UniProtKB:Q96EB6	Human	PMID:15469825
Molecular Function	GO:0005515	protein binding	H1-4	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	H1-4	IPI	UniProtKB:Q9Y468	Human	PMID:17540172
Molecular Function	GO:0005515	protein binding	H1-4	IPI	UniProtKB:Q8IY81	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	H1-4	IPI	UniProtKB:Q8IY81	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	H1f4	IPI	PR:Q99MD9	Mouse	PMID:10893414
Molecular Function	GO:0003723	RNA binding	H1-4	HDA		Human	PMID:22681889
Molecular Function	GO:0030527	structural constituent of chromatin	H1f4	IMP	MGI:MGI:2665857	Mouse	PMID:12808097
Cellular Component	GO:0000792	heterochromatin	H1-4	IDA		Human	PMID:15911621
Cellular Component	GO:0000786	nucleosome	H1f4	IDA		Rat	PMID:9109385|RGD:12793017
Cellular Component	GO:0005634	nucleus	H1-4	IDA		Human	PMID:17540172
Cellular Component	GO:0005634	nucleus	H1f4	IDA		Mouse	MGI:MGI:5559660|PMID:22868987
Biological Process	GO:0006325	chromatin organization	H1f4	IMP	MGI:MGI:2665857	Mouse	PMID:12808097
Biological Process	GO:0098532	histone H3-K27 trimethylation	H1f4	IGI	MGI:MGI:107502	Mouse	PMID:22701719
Biological Process	GO:0098532	histone H3-K27 trimethylation	H1f4	IGI	MGI:MGI:1931526	Mouse	PMID:22701719
Biological Process	GO:0080182	histone H3-K4 trimethylation	H1f4	IGI	MGI:MGI:1931526	Mouse	PMID:22701719
Biological Process	GO:0080182	histone H3-K4 trimethylation	H1f4	IGI	MGI:MGI:107502	Mouse	PMID:22701719
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	H1f4	IGI	MGI:MGI:107502	Mouse	PMID:22083958
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	H1f4	IGI	MGI:MGI:1931526	Mouse	PMID:22083958
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	H1f4	IMP		Mouse	PMID:22701719

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern