Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DQA1,HLA-DQA2
  • Mouse genes H2-Aa
  • Rat genes RT1-Ba
  • Zfish genes mhc2d8.35a1,mhc2d8.46a,mhc2dga,si:busm1-194e12.8,zgc:123107
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-Aa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042605	peptide antigen binding	H2-Aa	IDA		Mouse	PMID:9432982
Molecular Function	GO:0042605	peptide antigen binding	H2-Aa	IDA		Mouse	PMID:11069069
Molecular Function	GO:0005515	protein binding	HLA-DQA2	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HLA-DQA1	IPI	UniProtKB:P01920	Human	PMID:14769912
Molecular Function	GO:0005515	protein binding	HLA-DQA1	IPI	UniProtKB:P01920	Human	PMID:17629515
Molecular Function	GO:0005515	protein binding	HLA-DQA1	IPI	UniProtKB:P01920	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	H2-Aa	IPI	PR:P06345	Mouse	PMID:7985028
Molecular Function	GO:0044877	protein-containing complex binding	RT1-Ba	IDA		Rat	PMID:2465490|RGD:5147667
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:9432982
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:11148202
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:7679955
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:9492004
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:8598040
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:8598041
Cellular Component	GO:0009897	external side of plasma membrane	H2-Aa	IDA		Mouse	PMID:8638109
Cellular Component	GO:0005764	lysosome	H2-Aa	IDA		Mouse	PMID:11854359
Cellular Component	GO:0016020	membrane	HLA-DQA1	HDA		Human	PMID:19946888
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:11148202
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:8638109
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:7985028
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:9492004
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:8598041
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:8598040
Cellular Component	GO:0042613	MHC class II protein complex	H2-Aa	IDA		Mouse	PMID:7679955
Cellular Component	GO:0005886	plasma membrane	H2-Aa	IDA		Mouse	PMID:11854359
Biological Process	GO:0019882	antigen processing and presentation	H2-Aa	IDA		Mouse	PMID:9432982
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:11027433
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:7679955
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:9492004
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:9432982
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:8598040
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:8598041
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:11069069
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Aa	IDA		Mouse	PMID:11714799
Biological Process	GO:0048002	antigen processing and presentation of peptide antigen	H2-Aa	IDA		Mouse	PMID:11069069
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	RT1-Ba	IEP		Rat	PMID:12034349|RGD:5147665
Biological Process	GO:0042130	negative regulation of T cell proliferation	RT1-Ba	IDA		Rat	PMID:9834080|RGD:5147666
Biological Process	GO:0045582	positive regulation of T cell differentiation	H2-Aa	IDA		Mouse	PMID:8598041
Biological Process	GO:0034341	response to type II interferon	H2-Aa	IDA		Mouse	MGI:MGI:5009185|PMID:11465104

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern