Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DMA
  • Mouse genes H2-DMa
  • Rat genes RT1-DMa
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-DMa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMA	IDA		Human	PMID:22733780
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMA	IDA		Human	PMID:23260142
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMA	IDA		Human	PMID:9075930
Molecular Function	GO:0005515	protein binding	HLA-DMA	IPI	UniProtKB:P28068	Human	PMID:21131964
Molecular Function	GO:0005515	protein binding	HLA-DMA	IPI	UniProtKB:P28068	Human	PMID:23222639
Molecular Function	GO:0005515	protein binding	H2-DMa	IPI	MGI:MGI:95923	Mouse	PMID:9768758
Cellular Component	GO:0009986	cell surface	HLA-DMA	IDA		Human	PMID:22247549
Cellular Component	GO:0010008	endosome membrane	H2-DMa	IDA		Mouse	PMID:7985028
Cellular Component	GO:0005622	intracellular anatomical structure	H2-DMa	IDA		Mouse	PMID:9492004
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HLA-DMA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	H2-DMa	IDA		Mouse	PMID:7584146
Cellular Component	GO:0005770	late endosome	H2-DMa	IDA		Mouse	PMID:7985028
Cellular Component	GO:0031902	late endosome membrane	HLA-DMA	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	HLA-DMA	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	H2-DMa	IDA		Mouse	PMID:7985028
Cellular Component	GO:0005764	lysosome	H2-DMa	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005764	lysosome	H2-DMa	IDA		Mouse	PMID:7584146
Cellular Component	GO:0016020	membrane	HLA-DMA	HDA		Human	PMID:19946888
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMA	IDA		Human	PMID:22247549
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMA	IDA		Human	PMID:22733780
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMA	IDA		Human	PMID:7606781
Cellular Component	GO:0005771	multivesicular body	H2-DMa	IDA		Mouse	PMID:11854359
Biological Process	GO:0019882	antigen processing and presentation	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:9432982
Biological Process	GO:0019882	antigen processing and presentation	H2-DMa	IDA		Mouse	PMID:7985028
Biological Process	GO:0019882	antigen processing and presentation	H2-DMa	IDA		Mouse	PMID:7584146
Biological Process	GO:0019882	antigen processing and presentation	H2-DMa	IDA		Mouse	PMID:11148202
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:8598041
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-DMa	IMP	MGI:MGI:2384509	Mouse	PMID:8598040
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-DMa	IDA		Mouse	PMID:11027433
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:11714799
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:8638109
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMa	IDA		Mouse	PMID:11148202
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:8598041
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:11714799
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMa	IDA		Mouse	PMID:7985028
Biological Process	GO:0016064	immunoglobulin mediated immune response	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:11714799
Biological Process	GO:0048839	inner ear development	H2-DMa	IDA		Mouse	PMID:21795542
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMA	IDA		Human	PMID:22733780
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMA	IDA		Human	PMID:23260142
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMA	IDA		Human	PMID:7606781
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMA	IDA		Human	PMID:9075930
Biological Process	GO:0002636	positive regulation of germinal center formation	H2-DMa	IMP		Mouse	MGI:MGI:2153656|PMID:11714799
Biological Process	GO:0002922	positive regulation of humoral immune response	H2-DMa	IMP		Mouse	MGI:MGI:2153656|PMID:11714799
Biological Process	GO:0050778	positive regulation of immune response	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:11714799
Biological Process	GO:0045582	positive regulation of T cell differentiation	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:8638109
Biological Process	GO:0045582	positive regulation of T cell differentiation	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:8598041
Biological Process	GO:0045582	positive regulation of T cell differentiation	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:9432982
Biological Process	GO:0045582	positive regulation of T cell differentiation	H2-DMa	IMP	MGI:MGI:2384509	Mouse	PMID:8598040
Biological Process	GO:0045059	positive thymic T cell selection	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:8598041
Biological Process	GO:0045059	positive thymic T cell selection	H2-DMa	IMP	MGI:MGI:2652160	Mouse	PMID:8638109
Biological Process	GO:0045059	positive thymic T cell selection	H2-DMa	IMP	MGI:MGI:1861933	Mouse	PMID:9432982
Biological Process	GO:0045059	positive thymic T cell selection	H2-DMa	IMP	MGI:MGI:2384509	Mouse	PMID:8598040
Biological Process	GO:0015031	protein transport	H2-DMa	IDA		Mouse	PMID:8890155
Biological Process	GO:0065003	protein-containing complex assembly	H2-DMa	IDA		Mouse	PMID:7985028

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern