Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DMB
  • Mouse genes H2-DMb2
  • Rat genes RT1-DMb
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-DMb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMB	IDA		Human	PMID:22733780
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMB	IDA		Human	PMID:23260142
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DMB	IDA		Human	PMID:9075930
Molecular Function	GO:0005515	protein binding	HLA-DMB	IPI	UniProtKB:P28067	Human	PMID:21131964
Molecular Function	GO:0005515	protein binding	HLA-DMB	IPI	UniProtKB:P28067	Human	PMID:23222639
Molecular Function	GO:0005515	protein binding	H2-DMb2	IPI	PR:P28078	Mouse	PMID:9768758
Cellular Component	GO:0010008	endosome membrane	H2-DMb2	IDA		Mouse	PMID:7584146
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	HLA-DMB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	H2-DMb2	IDA		Mouse	PMID:7584146
Cellular Component	GO:0031902	late endosome membrane	HLA-DMB	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	HLA-DMB	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	H2-DMb2	IDA		Mouse	PMID:7584146
Cellular Component	GO:0005764	lysosome	H2-DMb2	IDA		Mouse	PMID:11854359
Cellular Component	GO:0016020	membrane	H2-DMb2	IDA		Mouse	PMID:7584146
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMB	IDA		Human	PMID:22247549
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMB	IDA		Human	PMID:22733780
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DMB	IDA		Human	PMID:7606781
Cellular Component	GO:0005771	multivesicular body	H2-DMb2	IDA		Mouse	PMID:11854359
Biological Process	GO:0019882	antigen processing and presentation	H2-DMb2	IDA		Mouse	PMID:7584146
Biological Process	GO:0019882	antigen processing and presentation	H2-DMb2	IDA		Mouse	PMID:11148202
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DMB	IMP		Human	PMID:8139689
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-DMb2	IDA		Mouse	PMID:11027433
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	H2-DMb2	IDA		Mouse	PMID:11148202
Biological Process	GO:0002399	MHC class II protein complex assembly	HLA-DMB	IMP		Human	PMID:8139689
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMB	IDA		Human	PMID:22733780
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMB	IDA		Human	PMID:23260142
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMB	IDA		Human	PMID:7606781
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DMB	IDA		Human	PMID:9075930
Biological Process	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	HLA-DMB	IMP		Human	PMID:8139689
Biological Process	GO:0042102	positive regulation of T cell proliferation	HLA-DMB	IMP		Human	PMID:8139689

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern