Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-DRA
  • Mouse genes H2-Ea
  • Rat genes RT1-Da
  • Zfish genes mhc2d8.35a1,mhc2d8.37a1,mhc2d8.46a,mhc2dga,si:busm1-194e12.8,zgc:123107
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-Ea

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0023026	MHC class II protein complex binding	HLA-DRA	HDA		Human	PMID:20458337
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:1448172
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:17583734
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:18697946
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:21502329
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:22733780
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:7477400
Molecular Function	GO:0042605	peptide antigen binding	HLA-DRA	IDA		Human	PMID:7606781
Molecular Function	GO:0030247	polysaccharide binding	HLA-DRA	IDA		Human	PMID:21502329
Molecular Function	GO:0005515	protein binding	HLA-DRA	IPI	UniProtKB:P01730	Human	PMID:27114505
Molecular Function	GO:0005515	protein binding	HLA-DRA	IPI	UniProtKB:P02458,UniProtKB:P01911	Human	PMID:9354468
Molecular Function	GO:0042608	T cell receptor binding	HLA-DRA	IDA		Human	PMID:29884618
Cellular Component	GO:0009986	cell surface	HLA-DRA	IDA		Human	PMID:21502329
Cellular Component	GO:0009897	external side of plasma membrane	H2-Ea	IDA		Mouse	PMID:7679955
Cellular Component	GO:0070062	extracellular exosome	HLA-DRA	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	HLA-DRA	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	HLA-DRA	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	HLA-DRA	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	HLA-DRA	HDA		Human	PMID:20458337
Cellular Component	GO:0001772	immunological synapse	HLA-DRA	IDA		Human	PMID:15322540
Cellular Component	GO:0001772	immunological synapse	HLA-DRA	IDA		Human	PMID:29884618
Cellular Component	GO:0031902	late endosome membrane	HLA-DRA	IDA		Human	PMID:18305173
Cellular Component	GO:0031902	late endosome membrane	HLA-DRA	IDA		Human	PMID:19117940
Cellular Component	GO:0031902	late endosome membrane	HLA-DRA	IDA		Human	PMID:9075930
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRA	IDA		Human	PMID:18305173
Cellular Component	GO:0005765	lysosomal membrane	HLA-DRA	IDA		Human	PMID:9075930
Cellular Component	GO:0005764	lysosome	HLA-DRA	IDA		Human	PMID:8890155
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IDA		Human	PMID:1448172
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IDA		Human	PMID:21502329
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IDA		Human	PMID:22733780
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IDA		Human	PMID:7477400
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IDA		Human	PMID:7606781
Cellular Component	GO:0042613	MHC class II protein complex	HLA-DRA	IMP		Human	PMID:9354468
Cellular Component	GO:0005886	plasma membrane	HLA-DRA	IDA		Human	PMID:8890155
Biological Process	GO:0002491	antigen processing and presentation of endogenous peptide antigen via MHC class II	HLA-DRA	IDA		Human	PMID:15322540
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	HLA-DRA	IDA		Human	PMID:15265931
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ea	IDA		Mouse	PMID:11714799
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	H2-Ea	IDA		Mouse	PMID:11027433
Biological Process	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	HLA-DRA	IDA		Human	PMID:21502329
Biological Process	GO:0050890	cognition	HLA-DRA	IMP		Human	PMID:23227193
Biological Process	GO:0016064	immunoglobulin mediated immune response	H2-Ea	IDA		Mouse	PMID:11714799
Biological Process	GO:0016064	immunoglobulin mediated immune response	H2-Ea	IGI	MGI:MGI:95921	Mouse	PMID:11714799
Biological Process	GO:0002469	myeloid dendritic cell antigen processing and presentation	HLA-DRA	IDA		Human	PMID:29884618
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRA	IDA		Human	PMID:1448172
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRA	IDA		Human	PMID:22733780
Biological Process	GO:0002503	peptide antigen assembly with MHC class II protein complex	HLA-DRA	IDA		Human	PMID:7606781
Biological Process	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	HLA-DRA	IDA		Human	PMID:15265931
Biological Process	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	HLA-DRA	IDA		Human	PMID:28467828
Biological Process	GO:0050778	positive regulation of immune response	H2-Ea	IGI	MGI:MGI:95921	Mouse	PMID:11714799
Biological Process	GO:0050778	positive regulation of immune response	H2-Ea	IDA		Mouse	PMID:11714799
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	HLA-DRA	IDA		Human	PMID:27591323
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	HLA-DRA	IDA		Human	PMID:29884618
Biological Process	GO:0045622	regulation of T-helper cell differentiation	HLA-DRA	IDA		Human	PMID:15322540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern