Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HLA-G
  • Mouse genes H2-M3
  • Rat genes RT1-M3-1
  • Zfish genes mhc1lea,mhc1zaa,mhc1zba,mhc1zca,mhc1zea,mhc1zfa,mhc1zja,mhc1zka
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set H2-M3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042610	CD8 receptor binding	HLA-G	IDA		Human	PMID:12853576
Molecular Function	GO:0042802	identical protein binding	HLA-G	IPI	UniProtKB:P17693	Human	PMID:16455647
Molecular Function	GO:0042802	identical protein binding	HLA-G	IPI	UniProtKB:P17693	Human	PMID:18550825
Molecular Function	GO:0042605	peptide antigen binding	HLA-G	IDA		Human	PMID:20122941
Molecular Function	GO:0042605	peptide antigen binding	HLA-G	IDA		Human	PMID:7584149
Molecular Function	GO:0042605	peptide antigen binding	HLA-G	IDA		Human	PMID:8805247
Molecular Function	GO:0042605	peptide antigen binding	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Molecular Function	GO:0042605	peptide antigen binding	H2-M3	IDA		Mouse	PMID:16461341
Molecular Function	GO:0042605	peptide antigen binding	H2-M3	IDA		Mouse	PMID:16476767
Molecular Function	GO:0042605	peptide antigen binding	H2-M3	IDA		Mouse	PMID:8464890
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q99706	Human	PMID:10190900
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:P53618	Human	PMID:11520457
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:P53618	Human	PMID:12582157
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:P01732	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8NHL6	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8NHL6	Human	PMID:12874224
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q99706	Human	PMID:16366734
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:16455647
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8NHL6	Human	PMID:16455647
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:O95971	Human	PMID:16809620
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:17056715
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8NHL6	Human	PMID:19583775
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:24899623
Molecular Function	GO:0005515	protein binding	HLA-G	IPI	UniProtKB:P27797	Human	PMID:9640257
Molecular Function	GO:0042803	protein homodimerization activity	HLA-G	IDA		Human	PMID:12874224
Molecular Function	GO:0042803	protein homodimerization activity	HLA-G	IDA		Human	PMID:22802125
Molecular Function	GO:0005102	signaling receptor binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:20702625
Molecular Function	GO:0005102	signaling receptor binding	HLA-G	IPI	UniProtKB:Q8NHL6	Human	PMID:20702625
Molecular Function	GO:0005102	signaling receptor binding	HLA-G	IPI	UniProtKB:Q8N423	Human	PMID:22802125
Cellular Component	GO:0033106	cis-Golgi network membrane	HLA-G	IDA		Human	PMID:12582157
Cellular Component	GO:0005769	early endosome	HLA-G	IDA		Human	PMID:16366734
Cellular Component	GO:0009897	external side of plasma membrane	H2-M3	IDA		Mouse	PMID:16476767
Cellular Component	GO:0009897	external side of plasma membrane	H2-M3	IDA		Mouse	PMID:8464890
Cellular Component	GO:0016020	membrane	HLA-G	HDA		Human	PMID:19946888
Cellular Component	GO:0032398	MHC class Ib protein complex	H2-M3	IDA		Mouse	PMID:8464890
Cellular Component	GO:0005886	plasma membrane	HLA-G	IDA		Human	PMID:11290782
Cellular Component	GO:0005886	plasma membrane	HLA-G	IDA		Human	PMID:12582157
Biological Process	GO:0002287	alpha-beta T cell activation involved in immune response	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA-G	IDA		Human	PMID:7584149
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA-G	IDA		Human	PMID:8805247
Biological Process	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	H2-M3	IDA		Mouse	PMID:8464890
Biological Process	GO:0002477	antigen processing and presentation of exogenous peptide antigen via MHC class Ib	H2-M3	IDA		Mouse	PMID:16461341
Biological Process	GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent	H2-M3	IDA		Mouse	PMID:16299293
Biological Process	GO:0042742	defense response to bacterium	H2-M3	IDA		Mouse	PMID:16476767
Biological Process	GO:0042742	defense response to bacterium	H2-M3	IDA		Mouse	PMID:16461341
Biological Process	GO:0042742	defense response to bacterium	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	HLA-G	IDA		Human	PMID:20702625
Biological Process	GO:0016525	negative regulation of angiogenesis	HLA-G	IDA		Human	PMID:16809620
Biological Process	GO:2001199	negative regulation of dendritic cell differentiation	HLA-G	IDA		Human	PMID:20702625
Biological Process	GO:0070317	negative regulation of G0 to G1 transition	HLA-G	IDA		Human	PMID:24453251
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-G	IDA		Human	PMID:10190900
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	HLA-G	IMP		Human	PMID:12874224
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	HLA-G	IDA		Human	PMID:24453251
Biological Process	GO:0001915	negative regulation of T cell mediated cytotoxicity	HLA-G	IDA		Human	PMID:11290782
Biological Process	GO:0042130	negative regulation of T cell proliferation	HLA-G	IDA		Human	PMID:20702625
Biological Process	GO:0006809	nitric oxide biosynthetic process	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0002451	peripheral B cell tolerance induction	HLA-G	IDA		Human	PMID:24453251
Biological Process	GO:2000774	positive regulation of cellular senescence	HLA-G	IDA		Human	PMID:23184984
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	HLA-G	IDA		Human	PMID:16809620
Biological Process	GO:0032735	positive regulation of interleukin-12 production	HLA-G	IDA		Human	PMID:20702625
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	HLA-G	IDA		Human	PMID:19304799
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	HLA-G	IDA		Human	PMID:16366734
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	HLA-G	IDA		Human	PMID:19304799
Biological Process	GO:0002729	positive regulation of natural killer cell cytokine production	HLA-G	IDA		Human	PMID:23184984
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	HLA-G	IMP		Human	PMID:20448110
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	H2-M3	IDA		Mouse	PMID:16299293
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	H2-M3	IDA		Mouse	PMID:8464890
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	H2-M3	IDA		Mouse	PMID:16461341
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	H2-M3	IDA		Mouse	PMID:16476767
Biological Process	GO:0002666	positive regulation of T cell tolerance induction	HLA-G	IMP		Human	PMID:20448110
Biological Process	GO:0002645	positive regulation of tolerance induction	HLA-G	IMP		Human	PMID:22802125
Biological Process	GO:0032729	positive regulation of type II interferon production	H2-M3	IMP	MGI:MGI:3701255	Mouse	PMID:16476767
Biological Process	GO:0042270	protection from natural killer cell mediated cytotoxicity	HLA-G	IDA		Human	PMID:11290782
Biological Process	GO:0070207	protein homotrimerization	HLA-G	IDA		Human	PMID:12874224
Biological Process	GO:0002237	response to molecule of bacterial origin	H2-M3	IDA		Mouse	PMID:16299293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern